New hope for advanced cancers: JANX008 enters human testing

NCT ID NCT05783622

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This early-phase study tests a new drug called JANX008 in about 130 adults with advanced solid tumors, including lung, kidney, head and neck, colorectal, pancreatic, and breast cancers. The main goal is to check safety and find the right dose. Participants must have tried all standard treatments without success.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary โ€” we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

colorectal carcinoma colorectal neoplasm head and neck squamous cell carcinoma non-small cell lung carcinoma pancreatic ductal adenocarcinoma renal cell carcinoma small cell lung carcinoma Squamous Cell Carcinoma of Head and Neck triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • City of Hope Medical Center

    Duarte, California, 91010, United States

  • Henry Ford Health System

    Detroit, Michigan, 48202, United States

  • Laura and Isaac Perlmutter Cancer Center NYU Langone Health

    New York, New York, 10016, United States

  • Ohio State University Hospital

    Columbus, Ohio, 43210, United States

  • Rhode Island Hospital

    Providence, Rhode Island, 02903, United States

  • Sarah Cannon Research Institute

    Nashville, Tennessee, 37203, United States

  • The Christ Hospital Cancer Center

    Cincinnati, Ohio, 45219, United States

  • The University of Texas, MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • UPMC Hillman Cancer Center

    Pittsburgh, Pennsylvania, 15232, United States

  • University of California San Diego Moores Cancer Center

    San Diego, California, 92093, United States

  • University of California, Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

  • University of Chicago Medical Center

    Chicago, Illinois, 60637, United States

  • University of Michigan

    Ann Arbor, Michigan, 48109, United States

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, 27599, United States

  • University of Pennsylvania, Abramson Cancer Center

    Philadelphia, Pennsylvania, 19104, United States

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390, United States

  • Washington University

    St Louis, Missouri, 63110, United States

  • Winship Cancer Institute, Emory University

    Atlanta, Georgia, 30308, United States