New antibody drug takes aim at Hard-to-Treat cancers

NCT ID NCT04881045

Completed Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial tested a new drug called PF-07257876 in 29 people with advanced lung, head/neck, or ovarian cancers that had stopped responding to other treatments. The drug is a bispecific antibody designed to help the immune system attack cancer cells. The main goals were to check safety and find the right dose, not yet to prove it works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PF-07257876 (a bispecific antibody targeting CD47 and PD-L1)
What this could lead to: If it works, this could point toward a new treatment option for people with advanced cancers that have stopped responding to standard therapies.
What could go wrong: This is a very early (Phase 1) trial with only 29 participants, so it is primarily testing safety and dosing. It is too soon to know if the drug will shrink tumors or improve survival, and side effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Head and Neck Neoplasms head and neck squamous cell carcinoma lung neoplasm Neoplasm Metastasis non-small cell lung carcinoma ovarian cancer Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER OVARIAN CANCER SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK

Contacts and locations

Locations

Barnes-Jewish Hospital

St Louis, Missouri, 63110, United States
Duke Cancer Institute

Durham, North Carolina, 27710, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Highlands Oncology Group

Fayetteville, Arkansas, 72703, United States
Highlands Oncology Group

Rogers, Arkansas, 72758, United States
Highlands Oncology Group

Springdale, Arkansas, 72762, United States
Hoag Hospital Irvine

Irvine, California, 92618, United States
Hoag Memorial Hospital Presbyterian

Newport Beach, California, 92663, United States
Hospital Clinico de Valencia

Valencia, Valenciana, Comunitat, 46010, Spain
Hospital General Universitario Gregorio Marañon

Madrid, Madrid, Comunidad de, 28009, Spain
Hospital Universitari Vall d'Hebron

Barcelona, Barcelona [barcelona], 08035, Spain
Hospital Universitario 12 de Octubre

Madrid, Madrid, Comunidad de, 28041, Spain
John Theurer Cancer Center at Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Keck Hospital of USC

Los Angeles, California, 90033, United States
Keck Hospital of USC Pasadena

Pasadena, California, 91105, United States
Keck School of Medicine of USC

Los Angeles, California, 90033, United States
LAC+USC Medical Center

Los Angeles, California, 90033, United States
Magee-Womens Hospital of UPMC

Pittsburgh, Pennsylvania, 15213, United States
Mayo Clinic

Scottsdale, Arizona, 85259, United States
Mayo Clinic Hospital

Phoenix, Arizona, 85054, United States
Mayo Clinic Jacksonville

Jacksonville, Florida, 32224, United States
Mayo Clinic Rochester

Rochester, Minnesota, 55905, United States
Rhode Island Hospital

Providence, Rhode Island, 02903, United States
Seattle Cancer Care Alliance

Seattle, Washington, 98109, United States
Siteman Cancer Center - South County

St Louis, Missouri, 63129, United States
Siteman Cancer Center - St Peters

City of Saint Peters, Missouri, 63376, United States
Siteman Cancer Center - West County

Creve Coeur, Missouri, 63141, United States
Siteman Cancer Center-North County

Florissant, Missouri, 63031, United States
The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate

Los Angeles, California, 90025, United States
The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate (Emergency Back-Up Only)

Santa Monica, California, 90404, United States
The Miriam Hospital

Providence, Rhode Island, 02906, United States
UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
UPMC Hillman Cancer Center - Camp Hill

Camp Hill, Pennsylvania, 17011, United States
UPMC Hillman Cancer Center - Carlisle

Carlisle, Pennsylvania, 17015, United States
UPMC Hillman Cancer Center Erie

Erie, Pennsylvania, 16505, United States
UPMC Memorial

York, Pennsylvania, 17408, United States
UPMC Pinnacle - Community Osteopathic / Medical Sciences Pavilion (MSP)

Harrisburg, Pennsylvania, 17109, United States
UPMC Pinnacle - Ortenzio Cancer Center (OCC)

Mechanicsburg, Pennsylvania, 17050, United States
UPMC Shadyside Hospital

Pittsburgh, Pennsylvania, 15232, United States
USC/Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
Virginia Cancer Specialists

Fairfax, Virginia, 22031, United States
Washington University

St Louis, Missouri, 63110, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States

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