New smart drug targets tough cancers in first human trial

NCT ID NCT07360314

Recruiting now Disease control Sponsor: EMD Serono Research & Development Institute, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This early-stage trial tests a new drug called M7437 in people with advanced solid tumors that have not responded to standard treatments. M7437 is an antibody-drug conjugate designed to deliver chemotherapy directly to cancer cells that have a specific marker (Ly6E). The study aims to find a safe dose and check for early signs of tumor shrinkage. About 138 participants with cancers like lung, breast, ovarian, head and neck, pancreatic, or stomach cancer will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: M7437 (an antibody-drug conjugate that delivers a chemotherapy drug directly to cancer cells)
What this could lead to: If successful, this could lead to a new treatment option for several advanced solid tumors that have stopped responding to standard therapies.
What could go wrong: This is a very early (Phase 1) and small study, so the drug may not prove safe or effective. Side effects from the chemotherapy payload are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast neoplasm gastric cancer gastric neoplasm head and neck squamous cell carcinoma non-small cell lung carcinoma ovarian cancer ovarian carcinoma pancreatic ductal adenocarcinoma Squamous Cell Carcinoma of Head and Neck triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMORS

Contacts and locations

Locations

BC Cancer - Vancouver - BC Cancer Agency
NOT_YET_RECRUITING

Vancouver, Canada
Carolina BioOncology Institute, LLC - Cancer Therapy and Research Center
RECRUITING

Huntersville, North Carolina, 28078, United States
Hospital Universitari Vall d'Hebron - VHIO - Oncology - Phase I Unit
NOT_YET_RECRUITING

Barcelona, 08035, Spain
NEXT Houston
RECRUITING

Galveston, Texas, 77001, United States
NEXT Madrid - Hospital Universitario Quironsalud Madrid
NOT_YET_RECRUITING

Madrid, Spain
NEXT Oncology - PARENT
RECRUITING

San Antonio, Texas, 78229, United States
National Cancer Center Hospital
RECRUITING

Tokyo, Japan
Princess Margaret Cancer Centre
RECRUITING

Toronto, Canada
Yale University - Yale University School of Medicine
NOT_YET_RECRUITING

New Haven, Connecticut, 06510, United States

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