New vaccine could help throat cancer patients avoid radiation
NCT ID NCT06223568
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This phase 2 trial tests whether adding an experimental vaccine (PRGN-2009) to standard chemotherapy can improve outcomes for people with newly diagnosed HPV-related throat cancer, potentially allowing them to skip radiation. About 70 adults will receive either chemo alone or chemo plus the vaccine, followed by surgery. The goal is to see if the combination leads to a complete response in the tumor.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- PRGN-2009 vaccine combined with docetaxel and cisplatin chemotherapy
- What this could lead to
- If successful, this could offer a way to treat HPV-related throat cancer without radiation, reducing side effects while maintaining survival rates.
- What could go wrong
- This is a small, early-phase trial (70 people) testing a new vaccine. It may not work better than standard treatment, and side effects from the vaccine or chemo are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
National Institutes of Health Clinical Center
RECRUITINGBethesda, Maryland, 20892, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can Pre-Surgery immunotherapy prime the immune system to fight head and neck cancer?
- Can a new drug boost the power of chemoradiation against head and neck cancer?
- Blood test may tailor throat cancer treatment, sparing patients from harsh side effects
- Robotic surgery may spare throat cancer patients from chemo and radiation
- Experimental antibody combo aims to boost immune attack on head and neck tumors
- Vaccine trains immune system to fight HPV-Positive head and neck tumors