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Robotic surgery may spare throat cancer patients from chemo and radiation

NCT ID NCT05419089

Recruiting now ⭐️ CURE ⭐️ Sponsor: Icahn School of Medicine at Mount Sinai Source: ClinicalTrials.gov ↗

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This phase 2 trial is testing whether robotic surgery alone can control HPV-related throat cancer, potentially sparing patients the long-term side effects of chemotherapy and radiation. The study enrolls people with HPV-positive oropharyngeal cancer whose tumors are removable and who have no detectable cancer DNA in their blood after surgery. Researchers are asking whether this less intensive approach can achieve survival rates similar to standard therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
transoral robotic surgery (TORS)
What this could lead to
If successful, this could allow some patients with HPV-related throat cancer to avoid chemotherapy and radiation, reducing long-term side effects while maintaining cancer control.
What could go wrong
This is a relatively small phase 2 trial, and it is not yet known whether surgery alone will be as effective as standard therapy. There is a risk of cancer recurrence without additional treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

human papillomavirus-related squamous cell carcinoma oropharynx squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HPV-POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Mount Sinai Health System

    RECRUITING

    New York, New York, 10019, United States

    Contact

  • Valley - Mount Sinai Comprehensive Cancer Care

    RECRUITING

    Paramus, New Jersey, 07652, United States

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