New antibody drug aims to unleash immune system on Hard-to-Treat cancers

NCT ID NCT06380816

Recruiting now Disease control Sponsor: Cancer Research UK Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tests a new drug, UCB4594, in people with advanced solid tumors that haven't responded to standard treatments. The drug is a monoclonal antibody that targets a protein called HLA-G on cancer cells, potentially helping the immune system attack them. The study aims to find the safest dose, understand side effects, and see if the drug can shrink tumors, either alone or with other cancer treatments.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

carcinoma cervical cancer clear cell renal carcinoma colorectal cancer colorectal neoplasm Esophageal Neoplasms gastric neoplasm gastroesophageal cancer head and neck squamous cell carcinoma malignant pancreatic neoplasm neoplasm neoplasm of esophagus non-small cell lung carcinoma ovarian cancer ovarian neoplasm pancreatic neoplasm renal cell carcinoma Squamous Cell Carcinoma of Head and Neck triple-negative breast carcinoma Uterine Cervical Neoplasms uterine cervix neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOURS CARCINOMA, NON-SMALL-CELL LUNG CARCINOMA, RENAL CELL (CLEAR CELL ONLY) COLORECTAL NEOPLASMS ESOPHAGEAL NEOPLASMS OVARIAN NEOPLASMS PANCREATIC NEOPLASMS SQUAMOUS CELL CARCINOMA OF HEAD AND NECK STOMACH NEOPLASMS (EXCLUDING GASTROINTESTINAL STROMAL TUMORS) TRIPLE NEGATIVE BREAST NEOPLASMS UTERINE CERVICAL NEOPLASMS

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Guy's Hopsital
RECRUITING

London, SE1 9RT, United Kingdom

Contact Phone: •••-•••-•••• Email: •••••@•••••
The Christie NHS Foundation Trust
RECRUITING

Manchester, United Kingdom

Contact Phone: •••-•••-•••• Email: •••••@•••••
The Newcastle upon Tyne Hospitals NHS Foundation Trust
RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom

Contact Phone: •••-•••-•••• Email: •••••@•••••
University Hospital Southampton NHS Foundation Trust
NOT_YET_RECRUITING

Southampton, United Kingdom

Contact Email: •••••@•••••