PANCREATIC NEOPLASMS

This trial tests a new drug, UCB4594, designed to help the immune system attack cancer cells by targeting a protein called HLA-G found on many tumors. It is for people with advanced solid cancers that have not responded to standard treatments. The study aims to find the safest do…

This early-phase study tests a new treatment called TNhYP218 CAR T cells for people with solid tumors, including mesothelioma, that have returned or spread after standard therapy. The treatment involves collecting a patient's own immune cells, modifying them in a lab to better re…

This study is testing a procedure called EUS-guided radiofrequency ablation (RFA) for people with pancreatic tumors that cannot be removed by surgery. A thin needle is passed through an endoscope into the tumor and uses heat to destroy cancer cells. The goal is to see if this tre…

This study tests an experimental drug called LY3537982 in people with advanced solid tumors that have a specific KRAS G12C mutation. The goal is to see if the drug is safe and shrinks tumors. About 540 adults with lung, colorectal, endometrial, ovarian, pancreatic, or bile duct c…

This study tests a new treatment for people with pancreatic cancer that has spread to the liver. The approach uses a special infusion to deliver chemotherapy and an immune-boosting drug directly to the liver, after first giving a baking soda solution to make the tumor environment…

This study tests whether adding TQB2868 and anlotinib to standard chemotherapy can help people with pancreatic cancer live longer without their disease getting worse. About 80 adults with advanced pancreatic cancer who have not had prior treatment will receive the combination the…

This study tests a new treatment for people with advanced pancreatic cancer whose tumors have a specific genetic change (KRAS G12V) and a certain immune type (HLA-A*11:01). The treatment uses the patient's own immune cells, modified in a lab to recognize and attack cancer cells. …

This study looks at how the genetic makeup of pancreatic cancer affects response to FOLFIRINOX chemotherapy given before surgery. About 45 adults with non-metastatic pancreatic cancer will receive chemo, then have their tumors analyzed. The goal is to see if certain tumor types r…

This international study compares two minimally invasive surgical techniques for removing benign or pre-cancerous tumors from the left side of the pancreas. 256 patients will be randomly assigned to either laparoscopic (surgeon uses hand-held tools) or robot-assisted surgery. Res…

This study is testing a new test called NEO-Match® that uses nanomechanical profiling to analyze biopsy samples from people with suspected pancreatic cancer. The goal is to see if the test can predict how well patients will respond to treatment and help doctors make better decisi…

This study aims to detect pancreatic cancer and its early warning signs in people who have a strong family history or certain genetic mutations. Participants will get MRI scans and give blood samples over time to help find cancer earlier and build a blood-based screening test. Ab…

This study is testing a new blood test that looks for tiny particles called exosomes to find pancreatic cancer early. Researchers will study 2,000 people, including those with and without the disease, to see how accurate the test is. If successful, it could lead to earlier diagno…

This study looks at whether a special ultrasound done before surgery can tell how firm the pancreas is and help predict the risk of a leak after pancreatic surgery. About 100 adults having their pancreas removed will get this ultrasound. The goal is to see if this simple test can…

This study is looking at tiny molecules called microRNAs in the blood of people with advanced pancreatic cancer. The goal is to see if these molecules can help doctors diagnose the disease earlier, predict how it will progress, and determine which treatments might work best. Rese…

This study follows 4,000 adults aged 30 and older who have at least one pancreatic cyst. The goal is to track which cysts turn into cancer and which stay harmless. By collecting data over time, researchers hope to create better guidelines to avoid unnecessary surgeries while catc…

This study looks at 800 people aged 50+ who recently developed diabetes or whose diabetes got worse. Researchers use MRI scans and blood samples to find early signs of pancreatic cancer. The goal is to see if changes in diabetes can lead to earlier detection of this cancer.

This study collects blood, urine, and tumor samples from up to 1,000 people with malignant mesothelioma and other cancers that express mesothelin. The goal is to build a tissue bank for future research into these diseases. Participants are followed over time to track their health…

This study is collecting information from 8,000 cancer patients treated with a special machine called the MR-Linac, which combines an MRI scanner with a radiation therapy device. The goal is to see how well this technology works for different cancers, including breast, prostate, …

This study follows 5,000 adults with pancreatic cysts to learn how these cysts behave over time. Researchers aim to create a better way to tell which cysts are harmless and which may turn into cancer. Participants provide medical records and samples, helping doctors improve early…

This study looks at whether analyzing the genetic makeup of a person's pancreatic tumor can help doctors pick more effective treatments. Researchers will review medical records from 1000 adult patients to see how often personalized therapy is used and how well it works. The goal …

This study looks at 206 people having surgery to remove a pancreatic tumor. It compares standard anesthesia (general) with a combination of general and epidural anesthesia to see which causes fewer drops in blood pressure during the operation. The goal is to find the safer approa…