Engineered immune cells take on Hard-to-Treat pancreatic cancer
NCT ID NCT04146298
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This trial tests a personalized cell therapy for advanced pancreatic cancer. Patients receive their own immune cells that have been engineered to recognize and attack cancer cells with a specific mutation (KRAS G12V). The study enrolls 30 people whose tumors carry this mutation and a specific immune type (HLA-A*11:01). The goal is to see if the treatment is safe and can shrink tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Mutant KRAS G12V-specific TCR transduced autologous T cells
- What this could lead to
- If it works, this could point toward a new treatment option for advanced pancreatic cancer patients with the KRAS G12V mutation.
- What could go wrong
- This is an early-phase trial with only 30 participants, so results may not apply to everyone. There are risks of serious side effects from the chemotherapy and cell infusion.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Changhai Hospital
RECRUITINGShanghai, 200433, China
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