Baking soda and chemo combo takes on tough pancreatic cancer

NCT ID NCT07504471

Recruiting now Disease control Sponsor: Ruijin Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new treatment for pancreatic cancer that has spread to the liver. Doctors deliver a mix of sodium bicarbonate (baking soda), chemotherapy drugs, and an immunotherapy drug directly into the liver's blood supply. The goal is to see if this approach helps people live longer. The trial is recruiting 50 adults with this specific type of cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Sodium bicarbonate, liposomal irinotecan, oxaliplatin, S-1, and a PD-1 inhibitor
What this could lead to: If successful, this could offer a new treatment option for people with pancreatic cancer that has spread to the liver, potentially improving survival.
What could go wrong: This is an early Phase II trial with only 50 participants, so results may not apply to everyone. The combination therapy has risks like side effects from chemotherapy and immunotherapy, and it may not work better than current treatments.

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Conditions

The condition(s) this trial relates to.

exocrine pancreatic carcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEPATIC METASTASIS OF PANCREATIC CANCER PANCREATIC NEOPLASMS

Contacts and locations

Locations

Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
RECRUITING

Shanghai, Shanghai Municipality, 2000010, China

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