Can High-Dose vitamin c boost chemo against pancreatic cancer?
NCT ID NCT02905578
First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This phase II trial tests whether adding high-dose vitamin C (ascorbate) to standard chemotherapy (gemcitabine and nab-paclitaxel) can help people with metastatic pancreatic cancer live longer. About 40 participants are randomly assigned to receive either standard chemo alone or chemo plus vitamin C. The study measures overall survival, tumor response, and side effects to see if the combination is more effective.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- high-dose vitamin C (ascorbate) given alongside gemcitabine and nab-paclitaxel chemotherapy
- What this could lead to
- If it works, this could point toward a more effective treatment for metastatic pancreatic cancer, a disease with very poor survival.
- What could go wrong
- This is a small, early-phase trial, so results may not apply broadly. High-dose vitamin C can cause kidney stones or other side effects when given intravenously.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
-
Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242, United States
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