University Of Iowa

This study tests a drug called dostarlimab in 25 people with stage II or III colon cancer that has a specific genetic feature (dMMR). The drug is given before any surgery to see if it can shrink the tumor enough that surgery may not be needed. Participants receive the drug every …

This study tests whether an oral medication (doxycycline) can help people with wet age-related macular degeneration (AMD) who still have fluid under their retina despite standard eye injections. About 50 participants will receive either doxycycline or a placebo for several months…

This study tests whether a single dose of psilocybin or ketamine, combined with talk therapy, can help people with moderate to severe alcohol use disorder drink less. Eighty adults who have at least four heavy drinking days per month will be randomly assigned to receive either ps…

This study looks at two common methods of giving extra opioids (strong painkillers) to patients recovering from open abdominal surgery who already have an epidural. Researchers want to see if adding opioids to the epidural fluid works as well as giving them through an IV, and whe…

This early study looks at whether a nerve block called a thoracolumbar interfascial plane (TLIP) block can help older adults (65 and older) have less pain and a better recovery after spinal fusion surgery. The block uses a numbing medicine called bupivacaine. The study will enrol…

This study looks at how changing the heel distraction height (the gap between the heel and the footplate) in a carbon fiber custom dynamic orthosis (CDO) affects foot loading, pain, and comfort during walking. Twenty adults with traumatic hindfoot injuries will walk with and with…

This study tests custom carbon fiber foot braces (orthoses) in 60 adults with lower leg injuries. Researchers measure how the braces reduce pressure on the forefoot during walking, and whether adding visual feedback or home use helps further. The goal is to improve comfort and re…

This study aims to understand why some people with epilepsy die suddenly (SUDEP). Researchers will measure how well patients sense carbon dioxide in their blood and how seizures affect breathing and heart function. 335 adults with epilepsy will be followed for up to 10 years. The…

This study looks at whether soaking hands in water for up to 20 minutes can be a simple screening tool for cystic fibrosis (CF) carrier status. Researchers will take photos of participants' hands and score the wrinkling, both by human observation and using a computer algorithm. T…

This study looks at two common emergency room drugs for a fast heart condition called SVT: adenosine and diltiazem. Adenosine can cause scary side effects like a feeling of doom, while diltiazem may lower blood pressure. Researchers will review medical records and ask 20 patients…

This study looks at whether people who carry one copy of the cystic fibrosis gene (but don't have the disease) are more likely to get dehydrated or have heat-related problems. Researchers will compare 100 carriers with 100 non-carriers using surveys and a 45-minute sauna challeng…

This study checks if special sensors can reliably measure forces inside carbon fiber ankle-foot braces (orthoses). Researchers will test healthy volunteers and people with or without neuropathy who already use such braces. Participants will walk, sit, and stand while sensors reco…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at whether inflammation caused by e-cigarette use harms blood vessel function in young adults aged 18-24. Researchers will compare chronic vapers to non-users, measuring blood vessel responses after giving an anti-inflammatory drug or placebo. The goal is to unde…

This study looks at whether computer-based brain exercises can help adults aged 40-65 stay physically active. Participants will do cognitive training and aerobic exercise at home with coach support. The goal is to see if improving thinking skills makes it easier to keep up an exe…

This study looks at whether early life adversity (like abuse or neglect) damages blood vessel function in young adults ages 18-29. Researchers will give participants a single dose of MitoQ, a supplement that targets cell energy centers, to see if it reduces stress-related damage.…

This study aims to find new genes that cause Charcot-Marie-Tooth disease (CMT) and discover why symptoms differ among people with the same genetic change. Researchers will analyze DNA from up to 1,050 participants to identify genetic modifiers and unknown causes. The goal is to b…