Scientists hunt for hidden genes behind nerve disease severity

NCT ID NCT01193088

Recruiting now Knowledge-focused Sponsor: University of Iowa Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to find new genes that cause Charcot-Marie-Tooth disease (CMT) and discover why symptoms differ among people with the same genetic change. Researchers will analyze DNA from up to 1,050 participants to identify genetic modifiers and unknown causes. The goal is to better understand the disease, not to test a treatment.

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Conditions

The condition(s) this trial relates to.

Charcot-Marie-Tooth disease Charcot-Marie-Tooth disease type 1A hereditary motor and sensory neuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHARCOT-MARIE-TOOTH DISEASE, TYPE IA (DISORDER) HMSN

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••
Contact

Email: •••••@•••••

Locations

C. Besta Neurological Institute
RECRUITING

Milan, Italy
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Children's Hospital of Westmead
RECRUITING

Sydney, New South Wales, 2145, Australia
Connecticut Children's Medical Center
RECRUITING

Hartford, Connecticut, 06106, United States
Dubowitz Neuromuscular Centre
RECRUITING

London, United Kingdom
Harvard/Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Houston Methodist Hospital
RECRUITING

Houston, Texas, 77030, United States
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21205, United States
National Hospital of Neurology and Neurosurgery
RECRUITING

London, England, WC1N 3BG, United Kingdom
Seattle Children's Hospital
RECRUITING

Seattle, Washington, 98105, United States
St. Jude Children's Research Hospital
RECRUITING

Memphis, Tennessee, 38105, United States
Stanford University
RECRUITING

Palo Alto, California, 94304, United States
The Hospital for Sick Children
RECRUITING

Toronto, Ontario, M5G 1X8, Canada
University of Colorado Hospital
RECRUITING

Aurora, Colorado, 80045, United States

Contact Email: •••••@•••••
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States

Contact Email: •••••@•••••
University of Miami
RECRUITING

Miami, Florida, 33136, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Minnesota
RECRUITING

Maple Grove, Minnesota, 55369, United States
University of North Carolina
RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Rochester
RECRUITING

Rochester, New York, 14642, United States