University Of Iowa

This study tests whether an oral antibiotic (doxycycline) can help people with wet age-related macular degeneration (AMD) who still have fluid in the eye despite standard injections. About 50 participants will receive either doxycycline or a placebo for up to 12 months. The goal …

This study tests whether psilocybin or ketamine, combined with talk therapy, can help people with moderate to severe alcohol use disorder drink less. Eighty adults who have at least 4 heavy drinking days per month will receive either psilocybin or ketamine in a controlled setting…

This study looks at whether a 6-week computer-based brain training program can help adults aged 40-65 stay physically active. Participants will also do home-based aerobic exercise with coach support. The goal is to see if improving thinking skills makes it easier to keep up an ex…

This study looks at two common ways to give extra pain medicine (opioids) to people recovering from open abdominal surgery. All participants will have an epidural for local anesthetic. The question is whether adding opioids to the epidural or giving them through an IV leads to be…

This study looks at how changing the heel height in carbon fiber custom braces affects foot pressure, pain, and comfort during walking. Researchers will test 20 adults aged 18-65 who have had a traumatic hindfoot injury and experience pain when putting weight on their foot. Parti…

This early study looks at whether a special type of nerve block (called TLIP) can improve pain and recovery in adults aged 65 and older having spinal fusion surgery. The blocks are given before surgery to reduce pain, opioid use, and the risk of confusion (delirium) after the ope…

This study tests custom carbon fiber foot braces (orthoses) in 60 adults with lower leg injuries. Researchers measure how the braces change foot pressure during walking, and whether adding visual feedback or home use helps further. The goal is to reduce forefoot loading and impro…

This study aims to find new genes that cause Charcot-Marie-Tooth disease (CMT) and identify genetic factors that influence symptom severity. Researchers will analyze DNA from up to 1,050 participants, including people with CMT and their relatives. The goal is to better understand…

This study looks at why some people with epilepsy die suddenly and unexpectedly (SUDEP). Researchers will monitor how seizures affect breathing, heart function, and the ability to wake up. They want to see if a weak response to high carbon dioxide levels during sleep or after a s…

This study looks at whether inflammation from e-cigarette use harms blood vessel function in young adults aged 18-24. Researchers will compare vapers and non-vapers by measuring skin blood flow after a mild heat test, with and without an anti-inflammatory drug. The goal is to und…

This study looks at how changing the heel height and stiffness of an ankle-foot brace (AFO) affects walking in people who use one daily. About 40 adults with leg injuries or nerve problems will walk with different heel cushions while researchers measure motion, comfort, and pain.…

This study looks at whether adults who carry one copy of the cystic fibrosis gene (called CF carriers) are more likely to get dehydrated or have heat-related problems. Researchers will compare 100 CF carriers with 100 non-carriers using surveys and a heat challenge in a sauna. Th…