Psychedelics take on alcoholism: psilocybin vs ketamine in new trial
NCT ID NCT06405607
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a single dose of psilocybin or ketamine, combined with talk therapy, can help people with moderate to severe alcohol use disorder drink less. Eighty adults who have at least four heavy drinking days per month will be randomly assigned to receive either psilocybin or ketamine along with psychotherapy. Researchers will track changes in drinking behavior and brain activity over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
psilocybin and ketamine
What this could lead to
If this works, it could point toward a new treatment option for alcohol use disorder using psychedelic-assisted therapy.
What could go wrong
This is a small, early-phase trial with only 80 participants, so results may not apply to everyone. Psychedelics can cause intense psychological experiences and are not risk-free.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Iowa Health Care
RECRUITINGIowa City, Iowa, 52240, United States
Contact Email: •••••@•••••