ALCOHOL DEPENDENCE

This study is testing whether a weekly injection called tirzepatide, currently used for diabetes and weight loss, can help reduce heavy alcohol use in people who also have schizophrenia. About 108 participants will receive either the real drug or a placebo (dummy injection) for 2…

This early study is testing two new long-acting injection versions of a medication called naltrexone, which is used to help manage opioid and alcohol dependence. The study will involve 40 healthy male volunteers to see how the body processes these new injections compared to the e…

This study is testing whether a non-invasive brain stimulation treatment can help people with moderate to severe alcohol use disorder reduce their heavy drinking. 186 participants will receive either the real magnetic stimulation treatment or a sham (fake) treatment over 6 months…

This study is testing whether a non-invasive brain stimulation technique can help people with alcohol addiction. Researchers will use magnetic pulses directed at specific brain areas to see if they reduce alcohol cravings and prevent relapse. The trial involves 72 participants in…

This study is testing whether adding gentle, non-invasive brain stimulation to a mindfulness-based relapse prevention program helps people with alcohol dependence stay sober better than the mindfulness program alone. It will involve 140 people who have recently stopped drinking. …

This study is testing whether psilocybin (from magic mushrooms) or ketamine (an anesthetic) works better when combined with therapy to help people reduce heavy drinking. Researchers will compare these two psychedelic treatments in 80 adults with moderate to severe alcohol use dis…

This study aims to develop and test simple computer tasks that can be used during brain scans to better understand how alcohol use disorders affect behavior, thinking, and decision-making. Researchers are recruiting 400 adults, including both healthy volunteers and people with al…

This study aims to understand the connection between alcohol use disorder and poor oral health. Researchers will test a new oral health questionnaire and collect saliva, blood, and dental exam data from people being treated for alcohol use disorder and healthy volunteers. The goa…

This study aims to understand how a non-invasive magnetic brain stimulation (TMS) affects brain activity in people with and without heavy alcohol use. Researchers will use a special brain scanner (MEG) to measure activity before and after the stimulation. The goal is to gather ea…

This study aims to understand how alcohol use disorder changes the brain. Researchers will use MRI brain scans and computer games to compare brain structure and function in adults with and without alcohol dependence. The goal is to link these brain differences to behavior, person…