ALCOHOL DEPENDENCE

This early-stage study tests two new long-acting injections, IVL3004 and IVL4002, in 40 healthy men aged 18-55. The goal is to see how the body processes these drugs compared to the approved medication Vivitrol, and to check for safety. If successful, these injections could offer…

This study tests whether a gentle nerve stimulation technique (tVNS) can make mindfulness training more effective at preventing relapse in people recovering from alcohol dependence. 140 detoxified patients will practice mindfulness with or without the stimulation. Researchers wil…

This study tests a non-invasive brain stimulation device called Deep TMS to see if it can reduce heavy drinking in people with moderate to severe alcohol use disorder. About 186 adults aged 18-86 will receive either real or fake (sham) stimulation over several weeks. The goal is …

This study tests a non-invasive brain stimulation method called theta burst stimulation to help people with alcohol addiction reduce cravings and avoid relapse. 72 adults who want to cut back or quit drinking will receive either real or fake stimulation. The goal is to see if thi…

This study tests whether tirzepatide, a drug approved for diabetes and obesity, can help people with both schizophrenia and alcohol use disorder drink less. About 108 participants will receive either tirzepatide or a placebo for 16 weeks, and researchers will track changes in hea…

This study tests whether psilocybin or ketamine, combined with talk therapy, can help people with moderate to severe alcohol use disorder drink less. Eighty adults who have at least 4 heavy drinking days per month will receive either psilocybin or ketamine in a controlled setting…

This study tests whether adding realistic smells to virtual reality scenes can help people with alcohol dependence manage their cravings. Researchers will have 20 participants experience VR environments with alcohol-related scents and measure how well they tolerate it and whether…

This study looks at how a non-invasive brain stimulation technique called TMS changes brain activity in people who drink heavily and those who don't. Researchers will use MEG brain scans to measure these effects in 10 volunteers. The goal is to gather information that could help …

This study looks at how stress and oral health habits relate to inflammation in people with alcohol use disorder (AUD). Researchers will collect saliva, blood, and dental exams from 72 participants (AUD patients and healthy volunteers). The goal is to improve understanding of ora…

This study aims to understand how the brains of people with alcohol dependence differ from those without it. Researchers will use MRI scans and computer games to look at brain structure and activity. About 1,000 adults aged 18 and older will participate in a single visit. No trea…

This study aims to create simple computer tasks that measure thinking, motivation, and decision-making in people with alcohol use disorders. Researchers will use MRI scans to see how the brain works during these tasks. The goal is to develop reliable tools for future studies, not…