New drug combo aims to keep ovarian cancer at bay

NCT ID NCT07318558

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times

Summary

This Phase 3 trial tests whether a targeted therapy called sacituzumab tirumotecan (Sac-TMT), given alone or with bevacizumab, can help people with advanced ovarian cancer live longer without their cancer growing. About 900 participants who have finished initial chemotherapy will receive either the study drug(s) or standard care. The goal is to find a better maintenance treatment option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

sacituzumab tirumotecan (Sac-TMT) and bevacizumab

What this could lead to

If successful, this could offer a new maintenance option to help people with advanced ovarian cancer live longer without their cancer worsening.

What could go wrong

This is a large Phase 3 trial, but it is still experimental. The drug may not improve outcomes over standard care, and side effects like infusion reactions or mouth sores are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

fallopian tube carcinoma ovarian cancer ovarian carcinoma ovarian neoplasm primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OVARIAN CANCER OVARIAN NEOPLASMS

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AZ Maria Middelares ( Site 0302)
RECRUITING

Ghent, Oost-Vlaanderen, 9000, Belgium

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Aalborg Universitetshospital ( Site 0901)
RECRUITING

Aalborg, North Denmark, 9000, Denmark

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Aarhus Universitetshospital, Skejby ( Site 0903)
RECRUITING

Aarhus, North Denmark, 8200, Denmark

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Addenbrookes Hospital ( Site 2802)
RECRUITING

Cambridge, Cambridgeshire, CB2 2QQ, United Kingdom

Contact Phone: •••-•••-••••
Agios Loukas Clinic ( Site 0702)
RECRUITING

Thessaloniki, 552 36, Greece

Contact Phone: •••-•••-••••
Alexandra General Hospital of Athens ( Site 0703)
RECRUITING

Athens, Attica, 115 28, Greece

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Asan Medical Center ( Site 2305)
RECRUITING

Seoul, 05505, South Korea

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Azienda Ospedaliera Spedali Civili di Brescia ( Site 1501)
RECRUITING

Brescia, 25123, Italy

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Bacs-Kiskun Varmegyei Oktatokorhaz-Onkoradiologiai Kozpont ( Site 3910)
RECRUITING

Kecskemét, Bács-Kiskun county, 6000, Hungary

Contact Phone: •••-•••-••••
Bialostockie Centrum Onkologii ( Site 2104)
RECRUITING

Bialystok, Podlaskie Voivodeship, 15-027, Poland

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CENTRE LEON BERARD ( Site 1101)
RECRUITING

Lyon, Auvergne-Rhône-Alpes, 69008, France

Contact Phone: •••-•••-••••
CIUSSS - Saguenay-Lac-Saint-Jean ( Site 0519)
RECRUITING

Chicoutimi, Quebec, G7H 5H6, Canada

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Cancer Institute Hospital of JFCR ( Site 1614)
RECRUITING

Koto, Tokyo, 135-8550, Japan

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Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne ( Site 1113)
RECRUITING

Clermont-Ferrand, Puy-de-Dome, 63003, France

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Centre Oscar Lambret ( Site 1106)
RECRUITING

Lille, Nord, 59020, France

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Clinica Universidad de Navarra ( Site 2407)
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Madrid, Madrid, Comunidad de, 28027, Spain

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Complejo Hospitalario Universitario A Coruna ( Site 2412)
RECRUITING

A Coruña, La Coruna, 15006, Spain

Contact Phone: •••-•••-••••
Debreceni Egyetem Klinikai Kozpont-Szülészeti és Nőgyógyászati Klinika ( Site 3912)
RECRUITING

Debrecen, 4032, Hungary

Contact Phone: •••-•••-••••
Edith Wolfson Medical Center ( Site 1423)
RECRUITING

Holon, 5810001, Israel

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Epworth Freemasons ( Site 0207)
RECRUITING

East Melbourne, Victoria, 3002, Australia

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FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0801)
RECRUITING

Bogotá, Bogota D.C., 110131, Colombia

Contact Phone: •••-•••-••••
Faculty of Medicine - Khon Kaen University ( Site 3403)
RECRUITING

Muang, Changwat Khon Kaen, 40002, Thailand

Contact Phone: •••-•••-••••
Faculty of Medicine Siriraj Hospital ( Site 3401)
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Bangkoknoi, Bangkok, 10700, Thailand

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Fakultni Nemocnice Brno Bohunice ( Site 3304)
RECRUITING

Brno, Brno-mesto, 602 00, Czechia

Contact Phone: •••-•••-••••
Fakultni nemocnice Kralovske Vinohrady ( Site 3306)
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Prague, 100 34, Czechia

Contact Phone: •••-•••-••••
Fakultni nemocnice Ostrava-Gynekologicko-porodnicka klinika ( Site 3303)
RECRUITING

Ostrava-Poruba, Ostrava Mesto, 708 52, Czechia

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Fakultni nemocnice motol ( Site 3302)
RECRUITING

Prague, 150 06, Czechia

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Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 1510)
RECRUITING

Roma, 00168, Italy

Contact Phone: •••-•••-••••
Fundación CORI para la Investigación y Prevención del Cáncer ( Site 2907)
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La Rioja, F5300COE, Argentina

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Fundación Respirar ( Site 2912)
RECRUITING

Buenos Aires, Buenos Aires F.D., C1426AAL, Argentina

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Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0414)
RECRUITING

São José do Rio Preto, São Paulo, 15090-000, Brazil

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Gallipoli Medical Research Ltd ( Site 0204)
RECRUITING

Brisbane, Queensland, 4120, Australia

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Grand Hopital de Charleroi ( Site 0303)
RECRUITING

Charleroi, Hainaut, 6000, Belgium

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Gunma Prefectural Cancer Center ( Site 1605)
RECRUITING

Ōta, Gunma, 373-8550, Japan

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Herlev Hospital ( Site 0902)
RECRUITING

Herlev, Capital Region, 2730, Denmark

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Hokkaido University Hospital ( Site 1609)
RECRUITING

Sapporo, Hokkaido, 060-8648, Japan

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Hopitaux Universitaires de Strasbourg ( Site 1109)
RECRUITING

Strasbourg, Bas-Rhin, 67000, France

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Hospital Aleman ( Site 2903)
RECRUITING

Ciudad Autonoma de Buenos Aires, Buenos Aires, C1119ACN, Argentina

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Hospital Britanico de Buenos Aires ( Site 2905)
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CABA, C1280AEB, Argentina

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Hospital Clinic I Provincial de Barcelona ( Site 2409)
RECRUITING

Barcelona, 08036, Spain

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Hospital Clinico San Carlos... ( Site 2410)
RECRUITING

Madrid, 28040, Spain

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Hospital Ramon y Cajal ( Site 2405)
RECRUITING

Madrid, 28034, Spain

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Hospital São Lucas da PUCRS ( Site 0415)
RECRUITING

Porto Alegre, Rio Grande do Sul, 90610000, Brazil

Contact Phone: •••-•••-••••
Hospital Universitario La Paz-Oncología Médica ( Site 2404)
RECRUITING

Madrid, 28046, Spain

Contact Phone: •••-•••-••••
Hospital Universitario Reina Sofia ( Site 2406)
RECRUITING

Córdoba, 14004, Spain

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Hospital Vall D Hebron ( Site 2403)
RECRUITING

Barcelona, 08035, Spain

Contact Phone: •••-•••-••••
Hyogo Cancer Center ( Site 1620)
RECRUITING

Akashi, Hyōgo, 673-8558, Japan

Contact Phone: •••-•••-••••
Hôpital Privé Des Côtes d'Armor ( Site 1102)
RECRUITING

Plérin, Cotes-d Armor, 22190, France

Contact Phone: •••-•••-••••
Hôpitaux Universitaires de Genève (HUG) ( Site 3502)
RECRUITING

Geneva, 1205, Switzerland

Contact Phone: •••-•••-••••
ICO L Hospitalet ( Site 2408)
RECRUITING

Barcelona, 08907, Spain

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Inselspital Bern ( Site 3504)
RECRUITING

Bern, Canton of Bern, 3010, Switzerland

Contact Phone: •••-•••-••••
Institut Català d'Oncologia (ICO) - Girona ( Site 2402)
RECRUITING

Girona, Gerona, 17007, Spain

Contact Phone: •••-•••-••••
Instituto Alexander Fleming ( Site 2902)
RECRUITING

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina

Contact Phone: •••-•••-••••
Instituto Nacional De Cancerologia ( Site 0808)
RECRUITING

Bogota, Cundinamarca, 111151, Colombia

Contact Phone: •••-•••-••••
Instituto Valenciano de Oncologia - IVO ( Site 2411)
RECRUITING

Valencia, Valenciana, Comunitat, 46009, Spain

Contact Phone: •••-•••-••••
Instituto de Investigaciones Clinicas Mar del Plata ( Site 2901)
RECRUITING

Mar del Plata, Buenos Aires, B7600FZO, Argentina

Contact Phone: •••-•••-••••
Instituto de Oncologia de Rosario ( Site 2909)
RECRUITING

Rosario, Santa Fe Province, S2000KZE, Argentina

Contact Phone: •••-•••-••••
Istituto Europeo di Oncologia ( Site 1503)
RECRUITING

Milan, 20141, Italy

Contact Phone: •••-•••-••••
Istituto Nazionale dei Tumori ( Site 1504)
RECRUITING

Milan, 20133, Italy

Contact Phone: •••-•••-••••
Iwate Medical University Hospital ( Site 1610)
RECRUITING

Shiwa-gun, Iwate, 028-3695, Japan

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Kagoshima City Hospital ( Site 1613)
RECRUITING

Kagoshima, 890-8760, Japan

Contact Phone: •••-•••-••••
Kantonsspital Graubünden ( Site 3503)
RECRUITING

Chur, Kanton Graubünden, 7000, Switzerland

Contact Phone: •••-•••-••••
Karolinska Universitetssjukhuset Solna ( Site 2502)
RECRUITING

Stockholm, Stockholm County, 171 76, Sweden

Contact Phone: •••-•••-••••
Keimyung University Dongsan Hospital ( Site 2304)
RECRUITING

Daegu, Taegu-Kwangyokshi, 42601, South Korea

Contact Phone: •••-•••-••••
Kuopion Yliopistollinen Sairaala ( Site 1004)
RECRUITING

Kuopio, Northern Savonia, 70200, Finland

Contact Phone: •••-•••-••••
Liga Norte Riograndense Contra o Cancer ( Site 0417)
RECRUITING

Natal, Rio Grande do Norte, 59062-000, Brazil

Contact Phone: •••-•••-••••
Linkou Chang Gung Memorial Hospital ( Site 2605)
RECRUITING

Taoyuan, 333, Taiwan

Contact Phone: •••-•••-••••
Mackay Memorial Hospital ( Site 2604)
RECRUITING

Taipei, 104, Taiwan

Contact Phone: •••-•••-••••
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 2102)
RECRUITING

Siedlce, Masovian Voivodeship, 08-110, Poland

Contact Phone: •••-•••-••••
McGill University Health Centre ( Site 0516)
RECRUITING

Montreal, Quebec, H4A 3J1, Canada

Contact Phone: •••-•••-••••
Medizinische Universitaet Innsbruck-Univ.-Klinik f. Gynäkologie und Geburtshilfe ( Site 0101)
RECRUITING

Innsbruck, Tyrol, 6020, Austria

Contact Phone: •••-•••-••••
Medizinische Universitat Wien ( Site 0102)
RECRUITING

Vienna, State of Vienna, 1090, Austria

Contact Phone: •••-•••-••••
Mount Sinai Cancer Center ( Site 0029)
RECRUITING

Miami Beach, Florida, 33140, United States

Contact Phone: •••-•••-••••
National Cheng Kung University Hospital ( Site 2602)
RECRUITING

Tainan, 704302, Taiwan

Contact Phone: •••-•••-••••
National Taiwan University Hospital ( Site 2601)
RECRUITING

Taipei, 10002, Taiwan

Contact Phone: •••-•••-••••
Nebraska Methodist Hospital ( Site 0004)
RECRUITING

Omaha, Nebraska, 68114, United States

Contact Phone: •••-•••-••••
Niigata Cancer Center Hospital ( Site 1608)
RECRUITING

Niigata, 951-8566, Japan

Contact Phone: •••-•••-••••
Odense Universitets Hospital ( Site 0904)
RECRUITING

Odense, Region Syddanmark, 9000, Denmark

Contact Phone: •••-•••-••••
Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0007)
RECRUITING

Tulsa, Oklahoma, 74146, United States

Contact Phone: •••-•••-••••
Oncólogos del Occidente S.A.S. ( Site 0806)
RECRUITING

Pereira, Risaralda Department, 660001, Colombia

Contact Phone: •••-•••-••••
Orlando Health Winnie Palmer Hospital for Women and Babies ( Site 0085)
RECRUITING

Orlando, Florida, 32806, United States

Contact Phone: •••-•••-••••
Országos Onkológiai Intézet-Ngyógyászat ( Site 3913)
RECRUITING

Budapest, 1122, Hungary

Contact Phone: •••-•••-••••
Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 1604)
RECRUITING

Osaka, 541-8567, Japan

Contact Phone: •••-•••-••••
Oslo University Hospital ( Site 2001)
RECRUITING

Oslo, 0424, Norway

Contact Phone: •••-•••-••••
Ospedale Regionale Bellinzona e Valli ( Site 3501)
RECRUITING

Bellinzona, Canton Ticino, 6500, Switzerland

Contact Phone: •••-•••-••••
Oulun yliopistollinen sairaala ( Site 1003)
RECRUITING

Oulu, North Ostrobothnia, 90220, Finland

Contact Phone: •••-•••-••••
Parkview Research Center at Parkview Regional Medical Center ( Site 0055)
RECRUITING

Fort Wayne, Indiana, 46845, United States

Contact Phone: •••-•••-••••
Petz Aladar Egyetemi Oktato Korhaz-Onkológiai Osztály ( Site 3911)
RECRUITING

Győr, Győr-Moson-Sopron, 9024, Hungary

Contact Phone: •••-•••-••••
Ramathibodi Hospital. ( Site 3402)
RECRUITING

Bangkok, Bangkok, 10400, Thailand

Contact Phone: •••-•••-••••
Rambam Health Care Campus ( Site 1422)
RECRUITING

Haifa, 3109601, Israel

Contact Phone: •••-•••-••••
Saitama Medical University International Medical Center ( Site 1607)
RECRUITING

Hidaka, Saitama, 350-1298, Japan

Contact Phone: •••-•••-••••
Samsung Medical Center ( Site 2303)
RECRUITING

Seoul, 06351, South Korea

Contact Phone: •••-•••-••••
Sanatorio Parque - Oncología ( Site 2911)
RECRUITING

Rosario, Santa Fe Province, S2000DVC, Argentina

Contact Phone: •••-•••-••••
Seoul National University Hospital ( Site 2301)
RECRUITING

Seoul, 03080, South Korea

Contact Phone: •••-•••-••••
Severance Hospital ( Site 2302)
RECRUITING

Seodaemun-Gu, Seoul, 03722, South Korea

Contact Phone: •••-•••-••••
Sheba Medical Center ( Site 1421)
RECRUITING

Ramat Gan, 5265601, Israel

Contact Phone: •••-•••-••••
Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 0802)
RECRUITING

Valledupar, Cesar Department, 200001, Colombia

Contact Phone: •••-•••-••••
Sorlandet Sykehus Kristiansand ( Site 2003)
RECRUITING

Kristiansand, Vest-Agder, 4615, Norway

Contact Phone: •••-•••-••••
Stavanger Universitetssjukehus ( Site 2002)
RECRUITING

Stavanger, Rogaland, 4068, Norway

Contact Phone: •••-•••-••••
Taichung Veterans General Hospital ( Site 2603)
RECRUITING

Taichung, 40705, Taiwan

Contact Phone: •••-•••-••••
Tampereen yliopistollinen sairaala ( Site 1002)
RECRUITING

Tampere, Pirkanmaa, 33520, Finland

Contact Phone: •••-•••-••••
The Christie NHS Foundation Trust ( Site 2804)
RECRUITING

Manchester, m20 4bx, United Kingdom

Contact Phone: •••-•••-••••
Turku University Hospital-Department of Obstetrics and Gynecology ( Site 1001)
RECRUITING

Turku, Southwest Finland, 20520, Finland

Contact Phone: •••-•••-••••
UZ Leuven ( Site 0301)
RECRUITING

Leuven, Vlaams-Brabant, 3000, Belgium

Contact Phone: •••-•••-••••
University Hospitals of Leicester NHS Trust ( Site 2805)
RECRUITING

Leicester, Leicestershire, LE3 9QP, United Kingdom

Contact Phone: •••-•••-••••
University Of Nebraska Medical Center ( Site 0035)
RECRUITING

Omaha, Nebraska, 68198, United States

Contact Phone: •••-•••-••••
University of Tennessee Medical Center ( Site 0087)
RECRUITING

Knoxville, Tennessee, 37920, United States

Contact Phone: •••-•••-••••
Uniwersytecki Szpital Kliniczny nr2 PUM w Szczecinie ( Site 2103)
RECRUITING

Szczecin, West Pomeranian Voivodeship, 70-111, Poland

Contact Phone: •••-•••-••••
Uniwersytecki Szpital Kliniczny w Poznaniu-Oddzial Ginekologii Onkologicznej ( Site 2106)
RECRUITING

Poznan, Greater Poland Voivodeship, 60-569, Poland

Contact Phone: •••-•••-••••
Vseobecna fakultni nemocnice v Praze ( Site 3305)
RECRUITING

Prague, 128 08, Czechia

Contact Phone: •••-•••-••••
West Cancer Center and Research Institute ( Site 0013)
RECRUITING

Germantown, Tennessee, 38138, United States

Contact Phone: •••-•••-••••
Wielkopolskie Centrum Onkologii im. Marii Skłodowskiej-Curie ( Site 2105)
RECRUITING

Poznan, Greater Poland Voivodeship, 61-866, Poland

Contact Phone: •••-•••-••••
Winship Cancer Institute of Emory University ( Site 0037)
RECRUITING

Atlanta, Georgia, 30308, United States

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Women & Infants Hospital ( Site 0001)
RECRUITING

Providence, Rhode Island, 02905, United States

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Women's Cancer Care ( Site 0018)
RECRUITING

Covington, Louisiana, 70433, United States

Contact Phone: •••-•••-••••