New drug combo aims to keep ovarian cancer at bay

NCT ID NCT07318558

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 12 times

Summary

This Phase 3 trial tests whether a targeted therapy called sacituzumab tirumotecan (Sac-TMT), given alone or with bevacizumab, can help people with advanced ovarian cancer live longer without their cancer growing. About 900 participants who have finished initial chemotherapy will receive either the study drug(s) or standard care. The goal is to find a better maintenance treatment option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: sacituzumab tirumotecan (Sac-TMT) and bevacizumab
What this could lead to: If successful, this could offer a new maintenance option to help people with advanced ovarian cancer live longer without their cancer worsening.
What could go wrong: This is a large Phase 3 trial, but it is still experimental. The drug may not improve outcomes over standard care, and side effects like infusion reactions or mouth sores are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

fallopian tube carcinoma ovarian cancer ovarian carcinoma ovarian neoplasm primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OVARIAN CANCER OVARIAN NEOPLASMS

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

ANIMI - Unidade de Tratamento Oncologico ( Site 0421)
RECRUITING

Lages, Santa Catarina, 88501-001, Brazil
ASST DI LECCO ( Site 1509)
RECRUITING

Lecco, 23900, Italy
AZ Maria Middelares ( Site 0302)
RECRUITING

Ghent, Oost-Vlaanderen, 9000, Belgium
Aalborg Universitetshospital ( Site 0901)
RECRUITING

Aalborg, North Denmark, 9000, Denmark
Aarhus Universitetshospital, Skejby ( Site 0903)
RECRUITING

Aarhus, North Denmark, 8200, Denmark
Addenbrookes Hospital ( Site 2802)
RECRUITING

Cambridge, Cambridgeshire, CB2 2QQ, United Kingdom
Agios Loukas Clinic ( Site 0702)
RECRUITING

Thessaloniki, 552 36, Greece
Alexandra General Hospital of Athens ( Site 0703)
RECRUITING

Athens, Attica, 115 28, Greece
Aretaieio Hospital ( Site 0701)
RECRUITING

Athens, Attica, 115 28, Greece
Asan Medical Center ( Site 2305)
RECRUITING

Seoul, 05505, South Korea
Azienda Ospedaliera Spedali Civili di Brescia ( Site 1501)
RECRUITING

Brescia, 25123, Italy
Bacs-Kiskun Varmegyei Oktatokorhaz-Onkoradiologiai Kozpont ( Site 3910)
RECRUITING

Kecskemét, Bács-Kiskun county, 6000, Hungary
Bialostockie Centrum Onkologii ( Site 2104)
RECRUITING

Bialystok, Podlaskie Voivodeship, 15-027, Poland
CENTRE LEON BERARD ( Site 1101)
RECRUITING

Lyon, Auvergne-Rhône-Alpes, 69008, France
CHRU de Brest - Hopital de la Cavale Blanche ( Site 1104)
RECRUITING

Brest, Finistere, 29200, France
CIUSSS - Saguenay-Lac-Saint-Jean ( Site 0519)
RECRUITING

Chicoutimi, Quebec, G7H 5H6, Canada
Cancer Institute Hospital of JFCR ( Site 1614)
RECRUITING

Koto, Tokyo, 135-8550, Japan
Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau ( Site 1105)
RECRUITING

Tours, Indre-et-Loire, 37044, France
Centre Hospitalier Universitaire Dupuytren ( Site 1112)
RECRUITING

Limoges, Haute-Vienne, 87042, France
Centre Hospitalier de l'Université de Montréal ( Site 0518)
RECRUITING

Montreal, Quebec, H2X 3H8, Canada
Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne ( Site 1113)
RECRUITING

Clermont-Ferrand, Puy-de-Dome, 63003, France
Centre Oscar Lambret ( Site 1106)
RECRUITING

Lille, Nord, 59020, France
Clinica Puerto Montt ( Site 0606)
RECRUITING

Port Montt, Los Lagos Region, 5507642, Chile
Clinica Universidad de Navarra ( Site 2407)
RECRUITING

Madrid, Madrid, Comunidad de, 28027, Spain
Clínica Alemana de Santiago ( Site 0610)
RECRUITING

Santiago, Region M. de Santiago, 7650568, Chile
Complejo Hospitalario Universitario A Coruna ( Site 2412)
RECRUITING

A Coruña, La Coruna, 15006, Spain
Debreceni Egyetem Klinikai Kozpont-Szülészeti és Nőgyógyászati Klinika ( Site 3912)
RECRUITING

Debrecen, 4032, Hungary
Duke Cancer Center ( Site 0012)
RECRUITING

Durham, North Carolina, 27710, United States
Edith Wolfson Medical Center ( Site 1423)
RECRUITING

Holon, 5810001, Israel
Epworth Freemasons ( Site 0207)
RECRUITING

East Melbourne, Victoria, 3002, Australia
FALP ( Site 0607)
RECRUITING

Santiago, Region M. de Santiago, 7500921, Chile
FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0801)
RECRUITING

Bogotá, Bogota D.C., 110131, Colombia
Faculty of Medicine - Khon Kaen University ( Site 3403)
RECRUITING

Muang, Changwat Khon Kaen, 40002, Thailand
Faculty of Medicine Siriraj Hospital ( Site 3401)
RECRUITING

Bangkoknoi, Bangkok, 10700, Thailand
Fakultni Nemocnice Brno Bohunice ( Site 3304)
RECRUITING

Brno, Brno-mesto, 602 00, Czechia
Fakultni nemocnice Hradec Kralove ( Site 3307)
RECRUITING

Hradec Králové, 500 05, Czechia
Fakultni nemocnice Kralovske Vinohrady ( Site 3306)
RECRUITING

Prague, 100 34, Czechia
Fakultni nemocnice Ostrava-Gynekologicko-porodnicka klinika ( Site 3303)
RECRUITING

Ostrava-Poruba, Ostrava Mesto, 708 52, Czechia
Fakultni nemocnice motol ( Site 3302)
RECRUITING

Prague, 150 06, Czechia
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 1510)
RECRUITING

Roma, 00168, Italy
Fundacion Colombiana de Cancerología Clinica Vida ( Site 0803)
RECRUITING

Medellín, Antioquia, 050030, Colombia
Fundación CORI para la Investigación y Prevención del Cáncer ( Site 2907)
RECRUITING

La Rioja, F5300COE, Argentina
Fundación Respirar ( Site 2912)
RECRUITING

Buenos Aires, Buenos Aires F.D., C1426AAL, Argentina
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0414)
RECRUITING

São José do Rio Preto, São Paulo, 15090-000, Brazil
Gallipoli Medical Research Ltd ( Site 0204)
RECRUITING

Brisbane, Queensland, 4120, Australia
Grand Hopital de Charleroi ( Site 0303)
RECRUITING

Charleroi, Hainaut, 6000, Belgium
Gunma Prefectural Cancer Center ( Site 1605)
RECRUITING

Ōta, Gunma, 373-8550, Japan
Henry-Joyce Cancer Clinic ( Site 0011)
RECRUITING

Nashville, Tennessee, 37232, United States
Herlev Hospital ( Site 0902)
RECRUITING

Herlev, Capital Region, 2730, Denmark
Hokkaido University Hospital ( Site 1609)
RECRUITING

Sapporo, Hokkaido, 060-8648, Japan
Hopitaux Universitaires de Strasbourg ( Site 1109)
RECRUITING

Strasbourg, Bas-Rhin, 67000, France
Hospital Aleman ( Site 2903)
RECRUITING

Ciudad Autonoma de Buenos Aires, Buenos Aires, C1119ACN, Argentina
Hospital Britanico de Buenos Aires ( Site 2905)
RECRUITING

CABA, C1280AEB, Argentina
Hospital Clinic I Provincial de Barcelona ( Site 2409)
RECRUITING

Barcelona, 08036, Spain
Hospital Clinico San Carlos... ( Site 2410)
RECRUITING

Madrid, 28040, Spain
Hospital Ramon y Cajal ( Site 2405)
RECRUITING

Madrid, 28034, Spain
Hospital São Lucas da PUCRS ( Site 0415)
RECRUITING

Porto Alegre, Rio Grande do Sul, 90610000, Brazil
Hospital Universitario La Paz-Oncología Médica ( Site 2404)
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Reina Sofia ( Site 2406)
RECRUITING

Córdoba, 14004, Spain
Hospital Vall D Hebron ( Site 2403)
RECRUITING

Barcelona, 08035, Spain
Hyogo Cancer Center ( Site 1620)
RECRUITING

Akashi, Hyōgo, 673-8558, Japan
Hôpital Privé Des Côtes d'Armor ( Site 1102)
RECRUITING

Plérin, Cotes-d Armor, 22190, France
Hôpitaux Universitaires de Genève (HUG) ( Site 3502)
RECRUITING

Geneva, 1205, Switzerland
ICO L Hospitalet ( Site 2408)
RECRUITING

Barcelona, 08907, Spain
Illinois Cancer Specialists (ICS) ( Site 8009)
RECRUITING

Arlington Heights, Illinois, 60005, United States
Inselspital Bern ( Site 3504)
RECRUITING

Bern, Canton of Bern, 3010, Switzerland
Institut Català d'Oncologia (ICO) - Girona ( Site 2402)
RECRUITING

Girona, Gerona, 17007, Spain
Institut Paoli Calmettes ( Site 1111)
RECRUITING

Marseille, Bouches-du-Rhone, 13273, France
Instituto Alexander Fleming ( Site 2902)
RECRUITING

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina
Instituto Nacional De Cancerologia ( Site 0808)
RECRUITING

Bogota, Cundinamarca, 111151, Colombia
Instituto Valenciano de Oncologia - IVO ( Site 2411)
RECRUITING

Valencia, Valenciana, Comunitat, 46009, Spain
Instituto de Investigaciones Clinicas Mar del Plata ( Site 2901)
RECRUITING

Mar del Plata, Buenos Aires, B7600FZO, Argentina
Instituto de Oncologia de Rosario ( Site 2909)
RECRUITING

Rosario, Santa Fe Province, S2000KZE, Argentina
Istituto Europeo di Oncologia ( Site 1503)
RECRUITING

Milan, 20141, Italy
Istituto Nazionale dei Tumori ( Site 1504)
RECRUITING

Milan, 20133, Italy
Iwate Medical University Hospital ( Site 1610)
RECRUITING

Shiwa-gun, Iwate, 028-3695, Japan
John Muir Health Cancer Center ( Site 0069)
RECRUITING

Walnut Creek, California, 94598, United States
Kagoshima City Hospital ( Site 1613)
RECRUITING

Kagoshima, 890-8760, Japan
Kantonsspital Graubünden ( Site 3503)
RECRUITING

Chur, Kanton Graubünden, 7000, Switzerland
Karolinska Universitetssjukhuset Solna ( Site 2502)
RECRUITING

Stockholm, Stockholm County, 171 76, Sweden
Keimyung University Dongsan Hospital ( Site 2304)
RECRUITING

Daegu, Taegu-Kwangyokshi, 42601, South Korea
Keio University Hospital ( Site 1611)
RECRUITING

Shinjyuku, Tokyo, 160-8582, Japan
Kuopion Yliopistollinen Sairaala ( Site 1004)
RECRUITING

Kuopio, Northern Savonia, 70200, Finland
Kurume University Hospital ( Site 1615)
RECRUITING

Kurume, Fukuoka, 830-0011, Japan
Liga Norte Riograndense Contra o Cancer ( Site 0417)
RECRUITING

Natal, Rio Grande do Norte, 59062-000, Brazil
Linkou Chang Gung Memorial Hospital ( Site 2605)
RECRUITING

Taoyuan, 333, Taiwan
Mackay Memorial Hospital ( Site 2604)
RECRUITING

Taipei, 104, Taiwan
Maine Medical Center Research Institute-MaineHealth/Maine Medical Partners - GynOnc ( Site 0060)
RECRUITING

Scarborough, Maine, 04074, United States
Maryland Oncology Hematology, P.A. ( Site 8002)
RECRUITING

Columbia, Maryland, 21044, United States
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 2102)
RECRUITING

Siedlce, Masovian Voivodeship, 08-110, Poland
McGill University Health Centre ( Site 0516)
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Medizinische Universitaet Innsbruck-Univ.-Klinik f. Gynäkologie und Geburtshilfe ( Site 0101)
RECRUITING

Innsbruck, Tyrol, 6020, Austria
Medizinische Universitat Wien ( Site 0102)
RECRUITING

Vienna, State of Vienna, 1090, Austria
Mount Sinai Cancer Center ( Site 0029)
RECRUITING

Miami Beach, Florida, 33140, United States
National Cheng Kung University Hospital ( Site 2602)
RECRUITING

Tainan, 704302, Taiwan
National Hospital Organization Kyushu Cancer Center ( Site 1603)
RECRUITING

Fukuoka, 811-1395, Japan
National Taiwan University Hospital ( Site 2601)
RECRUITING

Taipei, 10002, Taiwan
Nebraska Methodist Hospital ( Site 0004)
RECRUITING

Omaha, Nebraska, 68114, United States
Niigata Cancer Center Hospital ( Site 1608)
RECRUITING

Niigata, 951-8566, Japan
ONCOCENTRO APYS-ACEREY ( Site 0603)
RECRUITING

Viña del Mar, Valparaiso, 2520598, Chile
Obras Sociais Irma Dulce ( Site 0427)
RECRUITING

Salvador, Estado de Bahia, 41680-430, Brazil
Odense Universitets Hospital ( Site 0904)
RECRUITING

Odense, Region Syddanmark, 9000, Denmark
Okayama University Hospital ( Site 1619)
RECRUITING

Okayama, 700-8558, Japan
Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0007)
RECRUITING

Tulsa, Oklahoma, 74146, United States
Oncólogos del Occidente S.A.S. ( Site 0806)
RECRUITING

Pereira, Risaralda Department, 660001, Colombia
Orlando Health Winnie Palmer Hospital for Women and Babies ( Site 0085)
RECRUITING

Orlando, Florida, 32806, United States
Országos Onkológiai Intézet-Ngyógyászat ( Site 3913)
RECRUITING

Budapest, 1122, Hungary
Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 1604)
RECRUITING

Osaka, 541-8567, Japan
Oslo University Hospital ( Site 2001)
RECRUITING

Oslo, 0424, Norway
Ospedale Regionale Bellinzona e Valli ( Site 3501)
RECRUITING

Bellinzona, Canton Ticino, 6500, Switzerland
Oulun yliopistollinen sairaala ( Site 1003)
RECRUITING

Oulu, North Ostrobothnia, 90220, Finland
Parkview Research Center at Parkview Regional Medical Center ( Site 0055)
RECRUITING

Fort Wayne, Indiana, 46845, United States
Petz Aladar Egyetemi Oktato Korhaz-Onkológiai Osztály ( Site 3911)
RECRUITING

Győr, Győr-Moson-Sopron, 9024, Hungary
Pontificia Universidad Catolica de Chile ( Site 0602)
RECRUITING

Santiago, Region M. de Santiago, 8330073, Chile
Ramathibodi Hospital. ( Site 3402)
RECRUITING

Bangkok, Bangkok, 10400, Thailand
Rambam Health Care Campus ( Site 1422)
RECRUITING

Haifa, 3109601, Israel
Saitama Medical University International Medical Center ( Site 1607)
RECRUITING

Hidaka, Saitama, 350-1298, Japan
Samsung Medical Center ( Site 2303)
RECRUITING

Seoul, 06351, South Korea
Sanatorio Parque - Oncología ( Site 2911)
RECRUITING

Rosario, Santa Fe Province, S2000DVC, Argentina
Semmelweis Egyetem I. Szamu Szuleszeti es Nogyogyaszati Klinika ( Site 3915)
RECRUITING

Budapest, 1088, Hungary
Seoul National University Hospital ( Site 2301)
RECRUITING

Seoul, 03080, South Korea
Severance Hospital ( Site 2302)
RECRUITING

Seodaemun-Gu, Seoul, 03722, South Korea
Sheba Medical Center ( Site 1421)
RECRUITING

Ramat Gan, 5265601, Israel
Shizuoka Cancer Center ( Site 1618)
RECRUITING

Sunto-gun,, Shizuoka, 411-8777, Japan
Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 0802)
RECRUITING

Valledupar, Cesar Department, 200001, Colombia
Sorlandet Sykehus Kristiansand ( Site 2003)
RECRUITING

Kristiansand, Vest-Agder, 4615, Norway
St James Hospital ( Site 1302)
RECRUITING

Dublin, D08 E9P6, Ireland
Stavanger Universitetssjukehus ( Site 2002)
RECRUITING

Stavanger, Rogaland, 4068, Norway
Taichung Veterans General Hospital ( Site 2603)
RECRUITING

Taichung, 40705, Taiwan
Tampereen yliopistollinen sairaala ( Site 1002)
RECRUITING

Tampere, Pirkanmaa, 33520, Finland
The Center of Hope ( Site 0025)
RECRUITING

Reno, Nevada, 89511, United States
The Christie NHS Foundation Trust ( Site 2804)
RECRUITING

Manchester, m20 4bx, United Kingdom
Turku University Hospital-Department of Obstetrics and Gynecology ( Site 1001)
RECRUITING

Turku, Southwest Finland, 20520, Finland
UZ Leuven ( Site 0301)
RECRUITING

Leuven, Vlaams-Brabant, 3000, Belgium
University College London Hospitals ( Site 2801)
RECRUITING

London, London, City of, NW1 2PG, United Kingdom
University Hospitals of Leicester NHS Trust ( Site 2805)
RECRUITING

Leicester, Leicestershire, LE3 9QP, United Kingdom
University Of Nebraska Medical Center ( Site 0035)
RECRUITING

Omaha, Nebraska, 68198, United States
University of Cincinnati Medical Center ( Site 0042)
RECRUITING

Cincinnati, Ohio, 45219, United States
University of Tennessee Medical Center ( Site 0087)
RECRUITING

Knoxville, Tennessee, 37920, United States
Uniwersytecki Szpital Kliniczny nr2 PUM w Szczecinie ( Site 2103)
RECRUITING

Szczecin, West Pomeranian Voivodeship, 70-111, Poland
Uniwersytecki Szpital Kliniczny w Poznaniu-Oddzial Ginekologii Onkologicznej ( Site 2106)
RECRUITING

Poznan, Greater Poland Voivodeship, 60-569, Poland
Virginia Cancer Specialists (VCS) ( Site 8012)
RECRUITING

Fairfax, Virginia, 22031, United States
Virginia Oncology Associates (VOA) ( Site 8013)
RECRUITING

Norfolk, Virginia, 23502, United States
Vseobecna fakultni nemocnice v Praze ( Site 3305)
RECRUITING

Prague, 128 08, Czechia
West Cancer Center and Research Institute ( Site 0013)
RECRUITING

Germantown, Tennessee, 38138, United States
Westmead Hospital ( Site 0201)
RECRUITING

Westmead, New South Wales, 2145, Australia
Wielkopolskie Centrum Onkologii im. Marii Skłodowskiej-Curie ( Site 2105)
RECRUITING

Poznan, Greater Poland Voivodeship, 61-866, Poland
Winship Cancer Institute of Emory University ( Site 0037)
RECRUITING

Atlanta, Georgia, 30308, United States
Women & Infants Hospital ( Site 0001)
RECRUITING

Providence, Rhode Island, 02905, United States
Women's Cancer Care ( Site 0018)
RECRUITING

Covington, Louisiana, 70433, United States
Womens Cancer Care Associates, LLC ( Site 0023)
RECRUITING

Albany, New York, 12208-1743, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.