PANCREATIC NEOPLASM

This study tests a precise form of radiation called carbon ion radiotherapy in 33 frail adults with pancreatic cancer who cannot have surgery or standard chemotherapy. The goal is to see if this treatment can help them live longer and control the tumor with fewer side effects. Pa…

This early-phase trial tests whether combining two targeted drugs—sunitinib malate and lutetium Lu 177 dotatate (Lutathera)—is safe and effective for people with advanced pancreatic neuroendocrine tumors. About 24 participants will receive the combination to find the best dose an…

This study tests a less invasive procedure called endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) to treat pancreatic cysts that have a high risk of turning into cancer. The goal is to shrink these cysts by at least half, potentially preventing cancer without the n…

This study tests a new type of CAR T cell therapy for adults with advanced solid tumors (like colorectal, lung, or pancreatic cancer) that have lost a specific marker on their cells. The treatment uses the patient's own immune cells, modified to target cancer cells while protecti…

This study tests two drugs, trastuzumab and pertuzumab, already approved for breast cancer, in people with other rare cancers that have a specific genetic change called HER2 amplification or mutation. About 30 adults and children with various tumor types will receive the drug com…

This study tests a new drug called LY4170156 in people with advanced solid tumors, such as ovarian, lung, and breast cancers. The drug is designed to target and kill cancer cells while sparing healthy ones. The trial has two parts: first to find the safest dose, then to see how w…

This study tests whether giving the drug lanreotide before pancreatic surgery can prevent a common complication called a pancreatic fistula—a leak of digestive fluids that can cause infection. About 274 people with pancreatic cancer or precancerous lesions will be randomly assign…

This study tests if a nerve block using long-lasting numbing medicine works as well as an epidural for pain after pancreatic surgery. About 78 adults having this surgery will be randomly assigned to one of the two methods. The goal is to see if the nerve block provides similar pa…

This study looks at people who had part or all of their pancreas removed (pancreatectomy) to understand how the surgery affects their body's ability to control blood sugar and digest food. Researchers will review medical records from 3500 patients to see how different surgical me…

This study is testing a special MRI scan called 3D magnetic resonance elastography (MRE) to measure how stiff pancreatic tumors and surrounding scar tissue are. The goal is to see if these stiffness measurements can help predict how the cancer will respond to chemotherapy and how…

This study looks back at the medical records of about 3500 adults who had pancreatic surgery to find out why some develop delayed gastric emptying (stomach not emptying properly). The goal is to identify risk factors and improve care. No new treatments are tested; instead, resear…

This study looks at whether adding an MRI scan to the usual CT scan helps doctors choose the right treatment for people with pancreatic cancer. About 200 patients whose CT scans show no spread to the liver will be randomly assigned to get an MRI or not. The goal is to see if the …