PANCREATIC NEOPLASM

This study tests a new drug, LY4170156, designed to attack cancer cells with a specific marker (folate receptor alpha). It is for people with advanced solid tumors like ovarian, lung, or breast cancer that have not responded to other treatments. The trial has two parts: first fin…

This study tests a new treatment using a patient's own immune cells, called CAR T cells, that are specially designed to target and kill solid tumor cells while leaving healthy cells unharmed. It is for adults with certain advanced cancers, including lung, colon, pancreatic, ovari…

This early-phase trial is testing whether combining two targeted therapies—sunitinib malate and Lutathera—is safe for people with advanced pancreatic neuroendocrine tumors that have spread or cannot be removed. Sunitinib blocks signals that help tumors grow, while Lutathera deliv…

This study tests a less invasive procedure called endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) to treat pancreatic cysts that have a high risk of turning into cancer. About 84 adults with pancreatic cysts at least 2 cm in size and showing concerning features wil…

This trial tests two drugs, trastuzumab and pertuzumab, already approved for breast cancer, in people with rare cancers that have a specific genetic change called HER2 amplification or mutation. About 30 adults and children with various rare or hard-to-treat cancers will receive …

This study tests a special type of radiation called carbon ion radiotherapy in 33 frail patients with pancreatic cancer who cannot have surgery or standard chemotherapy. The goal is to see if this treatment can help them live longer and control the tumor with fewer side effects. …

This study aims to see if adding simple blood tests and symptom reviews to standard screening can catch pancreatic cancer earlier in people with a high genetic risk. Researchers will enroll 5,000 participants who have certain gene mutations linked to pancreatic cancer. The goal i…

This study is testing whether adding an MRI scan to the usual CT scan helps doctors make better decisions about surgery for pancreatic cancer. About 200 patients who are initially thought to be candidates for surgery will be randomly assigned to get either a standard CT alone or …

This study tests if giving the drug lanreotide before pancreatic surgery can prevent a common complication called a pancreatic fistula, which is a leak of digestive fluids. About 274 people with pancreatic cancer or precancerous lesions will be randomly assigned to receive either…

This study tests whether a rectus sheath block using long-acting liposomal bupivacaine can control pain as well as the standard thoracic epidural after pancreatic surgery. About 78 adults undergoing open pancreaticoduodenectomy will be randomly assigned to one of the two methods.…

This study compares two ways of monitoring pancreatic cysts—more frequent versus less frequent scans—and looks for biomarkers in the blood that might help predict cancer risk. About 770 adults aged 50 to 75 with at least one cyst will take part. The goal is to find out which moni…

This study explores whether a special MRI technique called 3D magnetic resonance elastography (MRE) can accurately measure the stiffness of pancreatic tumors and surrounding scar tissue. Researchers will enroll 200 adults with pancreatic cancer to see if these stiffness measureme…

This study looks back at 3,500 people who had pancreas surgery to understand how the operation affects their blood sugar control, digestion, and overall quality of life. Researchers will compare different surgical methods and how much of the pancreas was removed. The goal is to h…

This study looks at why some people develop delayed gastric emptying (stomach not emptying properly) after pancreatic surgery. Researchers will review medical records of 3500 patients who had pancreatic surgery to find risk factors, such as surgical method or feeding tube use. Th…