New pain block could replace epidurals in pancreatic surgery
NCT ID NCT06411795
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a rectus sheath block using long-acting liposomal bupivacaine can control pain as well as the standard thoracic epidural after pancreatic surgery. About 78 adults undergoing open pancreaticoduodenectomy will be randomly assigned to one of the two methods. The goal is to see if the new block reduces opioid use and avoids the low blood pressure risk linked to epidurals.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Liposomal bupivacaine
What this could lead to
If it works, this could offer a safer, equally effective pain control option after pancreatic surgery, reducing the risk of low blood pressure from epidurals.
What could go wrong
This is a small, early-phase trial (78 people) testing non-inferiority, so it may not prove the new block is truly as good. Results may not apply to all patients.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for PANCREATIC NEOPLASM are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
University of Minnesota/Masonic Cancer Center
RECRUITINGMinneapolis, Minnesota, 55455, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact