Sixth Affiliated Hospital, Sun Yat-sen University

This study is testing whether adding a PD-1 immunotherapy drug to standard chemotherapy and radiation improves outcomes for people with a rare type of rectal cancer. It will enroll about 20 adults with newly diagnosed, non-metastatic rectal squamous cell carcinoma. The main goal …

This study is for adults with active Crohn's disease who are not getting better on their current standard dose of ustekinumab. It will test if adding a second drug (upadacitinib) works better and is as safe as simply giving a higher dose of the original drug. Researchers will com…

This study looks back at medical records to compare two types of minimally invasive breast cancer surgeries: robot-assisted and endoscopic approaches. Researchers will examine 200 women with early-stage breast cancer who had one of these procedures. The goal is to understand whic…

This study is testing whether a special liquid-only diet, called exclusive enteral nutrition (EEN), can help adults with active and complicated Crohn's disease. Researchers will follow 300 participants for 12 weeks to see if the diet reduces symptoms, improves gut health, and is …

This study is testing a new three-part treatment for people with high-risk colon cancer that doesn't typically respond well to immunotherapy alone. It combines a special type of radiation designed to spare lymph nodes, followed by chemotherapy and an immunotherapy drug (PD-1 inhi…

This study aims to find out if patients with locally advanced colorectal cancer still need chemotherapy after they've already had successful pre-surgery treatment that reduced their cancer stage. Researchers will compare outcomes between patients who receive standard chemotherapy…

This study looks back at the medical records of 150 adults with moderate-to-severe ulcerative colitis (UC) to see which treatment approach worked better in real life. It compares patients who took a pill called upadacitinib by itself to those who took that same pill along with an…

This study is testing whether a precise, high-dose radiation treatment can help control rectal cancer that has come back and cannot be removed by surgery. The goal is to see if this treatment can shrink tumors enough to make surgery possible or extend survival. The trial will enr…

This study is testing if patients with a specific type of rectal cancer can safely avoid major surgery after their cancer disappears with immunotherapy. Researchers want to see if close monitoring, called 'watch and wait,' is a safe option for these patients. The goal is to help …

This study is testing if adding treatment for a common stomach bacteria (H. pylori) to standard chemotherapy works better for patients with locally advanced stomach cancer. About 200 participants will receive chemotherapy before and after surgery. Half will also get the H. pylori…

This study is testing a new three-part treatment for people with high-risk colon cancer that hasn't spread. The goal is to shrink the tumor as much as possible before surgery. Patients receive a very low dose of radiation designed to spare lymph nodes, along with standard chemoth…

This study is testing a special type of MRI scan to see if it can accurately tell whether a patient's rectal cancer has been completely eliminated by their initial treatment (chemotherapy/radiation) before they have surgery. The goal is to help doctors better decide which patient…

This study is testing if a personalized, carefully adjusted anesthesia method can reduce dangerous drops in blood pressure during surgery for older adults. Researchers will compare this approach to a standard fixed-dose method in 500 patients aged 65 and older having laparoscopic…

This study compares two surgical techniques for low rectal cancer to see which one better preserves patients' bowel control and quality of life after surgery. Researchers will randomly assign 256 patients to receive either the Parks or Bacon surgical method and then track their b…

This study is testing if a drug called megestrol acetate can help people with locally advanced colon or rectal cancer avoid losing weight during chemotherapy given before surgery. The trial will involve 60 patients, with half receiving the drug alongside their standard chemo and …

This study aims to better predict and monitor heart problems in cancer patients receiving chemotherapy. Researchers will follow 5,000 adults, using regular blood tests and heart scans to try to spot early signs of damage. The goal is to build a system that identifies patients at …

This study aims to see if taking the diabetes medication metformin before surgery affects how often or how badly patients feel nauseous or vomit afterwards. Researchers will observe and compare 909 patients having surgery—some who already take metformin and some who do not. The g…

This study aims to test a new prediction model that uses multiple types of patient data to forecast how well someone's rectal cancer will respond to treatment given before surgery. Researchers will enroll 106 patients with locally advanced rectal cancer to see if the model can ac…

This study aims to understand how different patterns of rectal injury from radiation therapy affect a patient's long-term recovery. Researchers will observe 150 patients over time, collecting medical information and test results without changing their treatment. The goal is to fi…

This study aims to understand if the bacteria living in our gut differ between people whose colorectal cancer has spread and those whose hasn't. Researchers will collect and analyze tissue and stool samples from 300 patients to look for bacterial patterns. The goal is to find new…