Sixth Affiliated Hospital, Sun Yat-sen University

This phase 2 trial is testing whether a combination of chemotherapy (mFOLFOX6), a targeted therapy (bevacizumab), and an immunotherapy (PD-1 inhibitor) can help people with a specific type of locally advanced colorectal cancer called microsatellite stable (MSS). Unlike other colo…

This study tested the drug upadacitinib in people with Crohn's disease that only affects the small bowel, a type that is often harder to treat. Researchers compared 3 patients with small-bowel Crohn's to others with Crohn's in different areas, using ultrasound to measure bowel in…

This study looked at 150 adults with Crohn's disease to see if advanced imaging could predict how well the drug Ustekinumab controls inflammation. Researchers measured changes in the gut wall and compared them to standard tests. The goal was to improve treatment monitoring for th…

This study looked at whether adding mesalazine (a standard anti-inflammatory drug) to biologic treatments like infliximab or vedolizumab helps people with moderate to severe ulcerative colitis achieve endoscopic remission (healing of the gut lining). The trial enrolled 438 adults…

This study analyzed data from 500 Crohn's disease patients to create a tool that uses routine blood tests to predict the risk of needing intestinal surgery. The goal is to help doctors move from reacting to problems to preventing them. The model is still in early development and …

This completed study looked at 300 Crohn's disease patients to see if CT scan images could predict who would need surgery within a year of diagnosis. Researchers built a computer model using 'radiomics' to analyze the scans. The goal is to help doctors start stronger treatments e…

This completed study from China looked at 50 adults with Crohn's disease who were treated with two newer biologic drugs, Ustekinumab and Vedolizumab. The goal was to see how well these drugs control the disease and what factors might predict a good response. By analyzing past med…

This completed observational study looked at 669 Crohn's disease patients to see if finding hidden anal fistulas early with MRI leads to better long-term health. Researchers compared patients who had no symptoms but were found to have fistulas on MRI to those who had symptoms. Th…

This completed study tested whether placing an arterial line 1.5-2.5 cm higher than the usual wrist site reduces problems like kinking or blockage. 486 adults having elective surgery were randomly assigned to the modified or traditional site. The goal was to see if the new spot l…

This study looked at 298 patients who had surgery for rectal cancer that came back in the same area. The goal was to find out how often the cancer returns again and what factors increase that risk. Researchers tracked long-term survival and identified key risk factors to help gui…

This study looked back at the medical records of 400 newborns with necrotizing enterocolitis (NEC), a serious gut disease. Researchers wanted to see if combining blood test results and organ function scores could better predict which babies would develop a hole in their bowel or …

This completed study looked at 1,471 colon cancer patients to see how their tumor's DNA repair status (pMMR vs dMMR) relates to lymph node spread and survival. Researchers hope to identify patients who might not need extensive lymph node removal. The study is observational and do…