Sixth Affiliated Hospital, Sun Yat-sen University

This study tests whether adding a special diet (the Crohn's Disease Exclusion Diet) to standard biologic drugs can improve gut healing in adults with active Crohn's disease. About 185 participants in China will be randomly assigned to receive either the diet plus biologics or bio…

This phase 2 trial tests whether a daily dexamethasone enema can prevent or reduce acute rectal injury in 40 rectal cancer patients undergoing pelvic radiotherapy. One group starts the enema early (day 10 of radiation), while the other starts only after injury occurs. The goal is…

This study will follow 178 Chinese adults with Crohn's disease or ulcerative colitis who are starting treatment with IL-23 inhibitors (guselkumab or risankizumab). Researchers will track how well the drugs control symptoms and heal the gut over 52 weeks, as well as any side effec…

This study tests whether delivering stem cells from bone marrow directly into the uterine artery can repair severe scarring inside the uterus (intrauterine adhesions) and improve pregnancy rates. Sixty women aged 20-38 with infertility due to this scarring will receive either sta…

This phase 3 trial will compare two drugs—ustekinumab (a shot) and upadacitinib (a pill)—in 454 adults with Crohn's disease that didn't get better with standard anti-TNF therapy. The goal is to see which drug leads to more people feeling better by week 16. Both drugs are already …

This study tests whether a daily Bergmann enema can prevent severe rectal injury caused by radiation therapy in 40 rectal cancer patients. Participants will receive the enema from the start of radiotherapy until 10 days after. The goal is to reduce the rate of moderate-to-severe …

This study tests a new type of nerve block (r-PVB) to reduce pain and improve recovery after laparoscopic gallbladder removal. About 250 adults having this surgery will either get the new block or standard care. The goal is to see if the block lowers pain scores and helps patient…

This study tests a new type of nerve block (r-PVB) to reduce pain and improve recovery after stoma closure surgery. 250 adults will receive either the new block or standard care. The goal is to see if the new method lowers pain scores and helps patients feel better faster.

This study compares a new, simpler nerve block method to the traditional one for people having lung surgery with a camera (VATS). The goal is to see if the new method works just as well for pain control and helps patients recover faster. About 200 adults will be randomly assigned…

This study tests whether a nasal spray called dexmedetomidine, taken at night, can help older adults (ages 65-90) sleep and reduce the risk of delirium after major abdominal surgery. 400 participants will be randomly assigned to receive either the drug or a placebo. The goal is t…

This study tests whether a special imaging mode called RDI helps doctors remove early-stage cancers from the stomach, esophagus, or colon more quickly and safely than standard white-light endoscopy. About 158 adults with early cancers or precancerous lesions will be randomly assi…

This study will compare two common anesthesia methods—inhaled gas versus intravenous drugs—to see which one causes less lung injury after major surgery in patients with sepsis. About 480 adults with sepsis who need surgery will be randomly assigned to one of the two groups. Resea…

This study tests a smartphone app that uses artificial intelligence to assess bowel preparation quality from patient-taken photos. About 524 adults undergoing colonoscopy will either use the app or receive standard care. If the app detects poor prep, it alerts staff to offer resc…

This study compares giving 30% versus 100% oxygen to patients just before they wake up from abdominal surgery. The goal is to see if a lower oxygen level reduces the chance of low blood oxygen after the breathing tube is removed. About 590 adults will take part, and the results c…