Sixth Affiliated Hospital, Sun Yat-sen University

This study looks at how well and how safely IL-23 inhibitors work for Chinese adults with inflammatory bowel disease (Crohn's disease or ulcerative colitis). About 178 people will receive these drugs as part of their normal care. The main goal is to see if the disease is under co…

This study tests whether adding a special diet (Crohn's Disease Exclusion Diet) to standard biologic therapy helps more adults with Crohn's disease achieve complete gut healing. About 185 participants in China will be randomly assigned to receive either the diet plus biologics or…

This study tests whether adding citrus flavonoid tablets (Aimailang) to standard chemotherapy (mFOLFOX) can shrink tumors more effectively before surgery in people with a specific type of advanced rectal cancer. About 236 participants with high YWHAB protein levels will receive e…

This study tests a new treatment for women who cannot get pregnant because of severe scarring inside the uterus. Doctors will inject stem cells from bone marrow directly into the uterine artery to help repair the lining. The trial will compare pregnancy rates between 60 women who…

This study tests whether adding a targeted therapy (cetuximab or bevacizumab) and an immunotherapy drug (PD-1 antibody) to standard short-course radiation and chemotherapy can better control high-risk rectal cancer that is not caused by certain gene faults. About 204 adults with …

This study tests two medications, ustekinumab and upadacitinib, against each other in people with Crohn's disease that hasn't responded to standard treatments. About 454 adults who have failed at least one anti-TNF therapy will be randomly assigned to one of the two drugs. The go…

This study is testing a smartphone app that uses artificial intelligence to help people prepare for colonoscopies. Patients will use the app at home to take photos of their stool after taking the prep solution; the AI will assess if their bowel is clean enough. If the app predict…

This study tests whether a daily Bergmann enema can prevent severe rectal injury in 40 rectal cancer patients undergoing short-course radiotherapy. The goal is to reduce the expected 80% injury rate to 50%. Participants will receive the enema from the start of radiation until 10 …

This study compares a new imaging technique called red dichromatic imaging (RDI) with standard white-light endoscopy during a procedure that removes early cancers or precancerous growths from the stomach, esophagus, or colon. The goal is to see if RDI helps doctors work faster an…

This study tests whether a nasal spray called dexmedetomidine, used at night, can help older adults (ages 65-90) sleep better and prevent delirium (sudden confusion) after major abdominal surgery. Half of the 400 participants will receive the spray, and half will receive a placeb…

This study tests a new type of nerve block (called revised-PVB) to see if it reduces pain and helps people recover faster after gallbladder removal surgery. About 250 adults having this surgery will either get the new block or standard care. The goal is to improve comfort and qua…

This study tests a new type of nerve block (called revised paravertebral block) to see if it reduces pain and helps patients recover faster after stoma closure surgery. About 250 adults having elective stoma reversal will receive either the new block or standard care. The main go…

This study tests whether a daily dexamethasone enema can reduce rectal injury caused by pelvic radiation in rectal cancer patients. About 40 adults will be randomly assigned to start the enema early or only after injury appears. The goal is to see if early use lowers the chance o…

This study compares giving 30% oxygen versus the usual 100% oxygen before removing the breathing tube after abdominal surgery. The goal is to see if a lower oxygen level reduces the chance of low oxygen after extubation. About 590 adults having abdominal surgery will take part.

This study looks at how often doctors should re-inflate the lungs during abdominal surgery to keep them working well. About 52 older adults having laparoscopic abdominal surgery will take part. The goal is to find the best time interval that helps 90% of patients achieve full lun…