Could citrus flavonoids boost chemo for rectal cancer? new trial launches

NCT ID NCT07176182

Recruiting now Disease control Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding a citrus flavonoid tablet (Aimailang) to standard chemotherapy (mFOLFOX) before surgery can shrink tumors more effectively in people with locally advanced rectal cancer that has a specific marker (YWHAB). About 236 participants will be randomly assigned to receive chemo alone or chemo plus the tablet for 4-6 cycles before surgery. The main goal is to see how many patients have their tumor stage reduced to a lower risk level after treatment.

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Conditions

The condition(s) this trial relates to.

rectal cancer rectal neoplasm rectum adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECTAL CANCER (STAGE III) RECTAL CANCER PATIENTS RECTAL CANCER STAGE II

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

The Sixth Affiliated Hospital of Sun Yat-sen University
RECRUITING

Guangzhou, Guangdong, 510655, China

Contact Phone: •••-•••-•••• Email: •••••@•••••