Radiation may spare early rectal cancer patients from radical surgery
NCT ID NCT07695519
First seen Jul 10, 2026 · Last updated Jul 10, 2026
Summary
This observational study follows about 196 adults with early-stage (pT1) rectal cancer who have high-risk features after local tumor removal. Instead of undergoing radical surgery that often requires a colostomy, participants receive adjuvant radiotherapy or chemoradiotherapy. The study tracks cancer recurrence, quality of life, and whether the organ-sparing approach is effective over three years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- adjuvant radiotherapy or chemoradiotherapy
- What this could lead to
- If successful, this study could show that adding radiotherapy after local tumor removal is a safe alternative to radical surgery, helping patients avoid a permanent colostomy.
- What could go wrong
- This is an observational study, not a controlled trial, so results may be less definitive. The risk of cancer recurrence remains, and radiotherapy has its own side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Roma, RM, 00168, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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