RECTAL CANCER PATIENTS

This study tests two ways of giving extra radiation after standard chemoradiation to people with early-stage rectal cancer. The goal is to see which method helps more people achieve a complete response, so they can avoid major surgery and keep their rectum. About 131 participants…

This study compares two modern surgical techniques for removing low rectal cancer: transanal total mesorectal excision (taTME) and robot-assisted total mesorectal excision (RTME). Researchers want to see which method leads to fewer complications and less need to switch to open su…

This study tests whether adding a citrus flavonoid tablet (Aimailang) to standard chemotherapy (mFOLFOX) before surgery can shrink tumors more effectively in people with locally advanced rectal cancer that has a specific marker (YWHAB). About 236 participants will be randomly ass…

This study tests whether adding a short course of radiation to a mix of immunotherapy (iparomlimab and tuvonralimab), a targeted drug (regorafenib), and chemotherapy (CAPOX) can better shrink advanced rectal cancer before surgery. About 88 adults with a specific type of rectal ca…

This phase 3 trial compares two different oral chemotherapy drugs given alongside radiation before surgery for locally advanced rectal cancer. The standard drug, capecitabine, is being tested against a newer drug called TAS-102. The goal is to see if TAS-102 leads to more tumors …

This phase 2 trial tests whether giving a combination of chemotherapy (oxaliplatin and capecitabine) and the immunotherapy drug tislelizumab before surgery can shrink or eliminate tumors in people with locally advanced rectal cancer. About 35 participants will receive three cycle…

This trial is testing whether a quick lab test during surgery can help some people with low rectal cancer avoid a major operation. After radiation therapy, patients with a good response undergo a small local excision. If the frozen section shows no deep cancer, they skip the larg…

This study is for people with locally advanced rectal cancer that hasn't spread. It tests whether adding an immunotherapy drug (PD-1 inhibitor) to a standard treatment plan (short-course radiation plus chemotherapy and targeted therapy) can lead to a complete disappearance of the…

This study compares two types of robotic surgery for rectal cancer: single-port (one small incision) and multi-port (several incisions). Researchers want to see which approach is safer and leads to fewer complications. Forty adults with rectal cancer will take part, and the study…

This study looks at sexual and gynecological problems that women may face after finishing treatment for rectal cancer. Researchers will survey 15 women in remission about their symptoms using standard questionnaires. The goal is to better understand these long-term effects and id…

This clinical trial is looking at how chemoradiation given before surgery affects circulating tumor cells (CTCs) in patients with stage II-III rectal cancer. CTCs are cancer cells that travel in the blood and may indicate how likely the cancer is to spread. The study will compare…