New study investigates whether chemoradiation before surgery reduces cancer cells in the blood

NCT ID NCT07194616

Recruiting now Knowledge-focused Sponsor: University Hospital Ostrava Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This clinical trial is looking at how chemoradiation given before surgery affects circulating tumor cells (CTCs) in patients with stage II-III rectal cancer. CTCs are cancer cells that travel in the blood and may indicate how likely the cancer is to spread. The study will compare two groups: one that gets chemoradiation followed by surgery, and another that has surgery alone. By tracking CTCs over time, researchers hope to learn more about which treatment approach might be better at controlling the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: fluoropyrimidine-based chemotherapy and radiotherapy
What this could lead to: If successful, this study could help doctors understand whether chemoradiation before surgery reduces the spread of cancer cells in the bloodstream, potentially guiding better treatment decisions for rectal cancer.
What could go wrong: This is an early-stage observational trial focused on a biomarker, not a direct treatment outcome. The results may not lead to immediate changes in patient care, and the sample size is relatively small.

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Conditions

The condition(s) this trial relates to.

Neoplastic Cells, Circulating rectal cancer rectal neoplasm rectum adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECTAL CANCER PATIENTS

Contacts and locations

Locations

Municipal Hospital Ostrava - Fifejdy
RECRUITING

Ostrava, 728 80, Czechia
Palacky University Olomouc, Faculty of Medicine
RECRUITING

Olomouc, Czechia
University Hospital Olomouc
RECRUITING

Olomouc, 779 00, Czechia
University Hospital Ostrava
RECRUITING

Ostrava, 70852, Czechia

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