CHEMO-FREE HOPE: new trial tests skipping Post-Surgery drugs for colorectal cancer
NCT ID NCT03748485
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is looking at whether people with locally advanced colorectal cancer who have already received chemotherapy or radiation before surgery can safely skip additional chemotherapy afterward. The trial will compare a 'wait and watch' approach to standard adjuvant chemotherapy in 650 participants whose cancer has been down-staged to stage II after pre-surgery treatment. The goal is to see if avoiding extra chemo can maintain similar outcomes while reducing side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- adjuvant chemotherapy (mFOLFOX6)
- What this could lead to
- If successful, this could show that some patients with locally advanced colorectal cancer can safely avoid additional chemotherapy after pre-surgery treatment, reducing side effects.
- What could go wrong
- This is an early-stage trial with no phase designation, and the benefit of skipping chemo is uncertain. The results may not apply to all patients, and there is a risk of cancer recurrence without chemotherapy.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Sixth Affiliated Hospital of Sun Yat-sen University
RECRUITINGGuangzhou, Guangdong, 510655, China
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