CHEMO-FREE HOPE: new trial tests skipping Post-Surgery drugs for colorectal cancer
NCT ID NCT03748485
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is looking at whether people with locally advanced colorectal cancer who have already received chemotherapy or radiation before surgery can safely skip additional chemotherapy afterward. The trial will compare a 'wait and watch' approach to standard adjuvant chemotherapy in 650 participants whose cancer has been down-staged to stage II after pre-surgery treatment. The goal is to see if avoiding extra chemo can maintain similar outcomes while reducing side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
adjuvant chemotherapy (mFOLFOX6)
What this could lead to
If successful, this could show that some patients with locally advanced colorectal cancer can safely avoid additional chemotherapy after pre-surgery treatment, reducing side effects.
What could go wrong
This is an early-stage trial with no phase designation, and the benefit of skipping chemo is uncertain. The results may not apply to all patients, and there is a risk of cancer recurrence without chemotherapy.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Sixth Affiliated Hospital of Sun Yat-sen University
RECRUITINGGuangzhou, Guangdong, 510655, China
Contact Phone: •••-•••-•••• Email: •••••@•••••