New cocktail aims to shrink stomach tumors before surgery
NCT ID NCT07165847
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This phase 2 trial tests whether adding radiotherapy and two immunotherapy drugs (iparomlimab and tuvonralimab) to standard chemotherapy can improve outcomes for people with resectable stomach or gastroesophageal junction cancer. About 40 participants will be randomly assigned to receive either the new combination or standard treatment before surgery. The main goal is to see how many patients have no cancer cells left in the removed tissue (pathological complete response).
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Iparomlimab and tuvonralimab (immunotherapy drugs), oxaliplatin and tegafur (chemotherapy), plus radiotherapy
- What this could lead to
- If successful, this combination could improve the chance of eliminating all visible cancer before surgery, potentially leading to better long-term outcomes for patients with gastric cancer.
- What could go wrong
- This is an early phase 2 trial with only 40 participants, so results may not apply to everyone. Adding immunotherapy and radiation to chemotherapy also increases the risk of side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Army Medical Center
RECRUITINGChongqing, Other (Non U.s.), 400000, China
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