Can a smart drug home in on Hard-to-Treat GI cancers?
NCT ID NCT07738939
First seen Jul 31, 2026 · Last updated Jul 31, 2026
Summary
This early-stage trial is testing an experimental treatment called the IKS04 regimen in people with advanced cancers of the digestive system, including colorectal, stomach, pancreatic, and bile duct cancers. The regimen combines a targeted antibody-drug conjugate with an additional antibody, both designed to seek out a protein called CA242 found on tumor cells. The goal is to determine the safest dose and to see whether it can shrink tumors or slow their growth.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- IKS04 antibody-drug conjugate plus Isumab04 monoclonal antibody
- What this could lead to
- If successful, this could lead to a new targeted treatment option for advanced gastrointestinal cancers that have stopped responding to standard therapies.
- What could go wrong
- This is an early-phase trial, so the treatment may not be effective or may cause significant side effects. The results will need confirmation in larger studies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Mass General Hospital
Boston, Massachusetts, 02114, United States
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UCLA Medical Center
Los Angeles, California, 90404, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
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