Could a zapping the gut help beat immunotherapy resistance?
NCT ID NCT07071103
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a low dose of radiation to the small intestine can help the immune system fight cancers that have stopped responding to immunotherapy. About 48 adults with advanced lung, esophageal, or other solid tumors will receive one radiation session followed by continued immunotherapy. Researchers will track tumor shrinkage, side effects, and changes in gut bacteria to see if this approach can restore treatment effectiveness.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Low-dose radiation to the intestine and PD-1/PD-L1 inhibitors
What this could lead to
If it works, this could offer a new treatment option for people whose cancers have stopped responding to immunotherapy.
What could go wrong
This is a small, early-phase trial with only 48 participants, so results may not apply to everyone. The combination may cause side effects or fail to improve outcomes.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cancer Hospital, Shantou University Medical College
RECRUITINGShantou, Guangdong, 515031, China
Contact