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Could a zapping the gut help beat immunotherapy resistance?

NCT ID NCT07071103

Recruiting now Disease control Sponsor: Chuangzhen Chen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a low dose of radiation to the small intestine can help the immune system fight cancers that have stopped responding to immunotherapy. About 48 adults with advanced lung, esophageal, or other solid tumors will receive one radiation session followed by continued immunotherapy. Researchers will track tumor shrinkage, side effects, and changes in gut bacteria to see if this approach can restore treatment effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Low-dose radiation to the intestine and PD-1/PD-L1 inhibitors
What this could lead to
If it works, this could offer a new treatment option for people whose cancers have stopped responding to immunotherapy.
What could go wrong
This is a small, early-phase trial with only 48 participants, so results may not apply to everyone. The combination may cause side effects or fail to improve outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

esophageal cancer Esophageal Neoplasms lung cancer lung neoplasm metastatic malignant neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DRUG RESISTANCE ESOPHAGEAL NEOPLASMS MALIGNANT IMMUNE CHECKPOINT BLOCKADE LUNG NEOPLASM MALIGNANT METASTATIC SOLID CANCERS RADIOTHERAPY

Contacts and locations

Locations

  • Cancer Hospital, Shantou University Medical College

    RECRUITING

    Shantou, Guangdong, 515031, China

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