Could vitamin d boost chemo success in breast cancer?

NCT ID NCT04677816

Recruiting now Disease control Sponsor: Wake Forest University Health Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether taking vitamin D supplements during standard chemotherapy can help more tumors disappear in people with triple-negative breast cancer who are low in vitamin D. About 50 participants will receive vitamin D plus chemotherapy, and researchers will compare their response to historical data. The goal is to see if correcting vitamin D deficiency improves the chance of a complete response.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vitamin D
What this could lead to: If it works, this could show that correcting vitamin D deficiency helps chemotherapy work better for triple-negative breast cancer.
What could go wrong: This is a small early-phase study with only 50 participants, so results may not apply broadly. Vitamin D may not improve outcomes, and standard chemotherapy side effects still apply.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

invasive breast carcinoma triple-negative breast carcinoma vitamin D deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INVASIVE BREAST CANCER TRIPLE NEGATIVE BREAST CANCER VITAMIN D DEFICIENCY

Contacts and locations

Locations

Wake Forest Baptist Health Sciences
RECRUITING

Winston-Salem, North Carolina, 27157, United States

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