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One-Time radiation during breast surgery could cut treatment time

NCT ID NCT06375798

Recruiting now Disease control Sponsor: Hebei Medical University Fourth Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether giving a single dose of radiation during breast-conserving surgery works as well as standard weeks-long radiation for early-stage, HER2-negative breast cancer. About 620 women aged 55 and older will take part. The goal is to see if this approach lowers the chance of cancer coming back, reduces side effects, and gives better cosmetic results.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
intraoperative radiotherapy (radiation given during surgery)
What this could lead to
If successful, this approach could offer a one-time radiation treatment during breast-conserving surgery, potentially reducing the need for weeks of daily radiation afterward.
What could go wrong
This is a single-center study, and results may not apply to all patients. The long-term safety and effectiveness compared to standard radiation are still being evaluated.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm ductal breast carcinoma in situ Her2-receptor negative breast cancer invasive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER HER2-NEGATIVE BREAST CANCER

Contacts and locations

Locations

  • The Fourth Hospital of Hebei Medical University

    RECRUITING

    Shijiazhuang, Hebei, China

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