New smart drug targets tough cancers in early trial

NCT ID NCT07090499

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This early-phase study tests an experimental drug called PF-08046876 in about 310 adults with advanced cancers of the bladder, lung, head and neck, esophagus, or pancreas that have not responded to standard treatments. The drug is a type of 'antibody drug conjugate' designed to stick to cancer cells and kill them directly. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors.

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Conditions

The condition(s) this trial relates to.

Adenocarcinoma Of Esophagus Adenocarcinoma of Lung esophageal adenocarcinoma esophageal cancer Esophageal Neoplasms esophageal squamous cell carcinoma exocrine pancreatic carcinoma gastroesophageal junction adenocarcinoma head and neck cancer Head and Neck Neoplasms head and neck squamous cell carcinoma malignant pancreatic neoplasm metastatic malignant neoplasm neoplasm non-small cell lung carcinoma pancreatic adenocarcinoma pancreatic neoplasm Squamous Cell Carcinoma of Head and Neck transitional cell carcinoma urinary bladder cancer urinary bladder carcinoma Urinary Bladder Neoplasms urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED NON-SMALL CELL LUNG CANCER ADVANCED/METASTATIC SOLID TUMORS BLADDER CANCER CARCINOMA, NON-SMALL-CELL LUNG CARCINOMA, SQUAMOUS CELL OF HEAD AND NECK ESOPHAGEAL ADENOCARCINOMA ESOPHAGEAL CANCER ESOPHAGEAL SQUAMOUS CELL CARCINOMA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA HEAD AND NECK CANCER PANCREATIC ADENOCARCINOMA PANCREATIC CANCER UROTHELIAL CARCINOMA

Contacts and locations

Locations

Barts Cancer Centre at St. Bartholomew's Hospital; Queen Mary University of London
NOT_YET_RECRUITING

London, EC1A 7BE, United Kingdom
Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
City of Hope National Medical Center
RECRUITING

Duarte, California, 91010, United States
City of Hope at Irvine Lennar
RECRUITING

Irvine, California, 92618, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Dana-Farber Cancer Institute - Chestnut Hill
RECRUITING

Newton, Massachusetts, 02467, United States
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, Barcelona [barcelona], 08035, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, Madrid, Comunidad de, 28041, Spain
Hospital Universitario Fundación Jiménez Díaz
RECRUITING

Madrid, 28040, Spain
McGill University Health Centre
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
NEXT Oncology
RECRUITING

San Antonio, Texas, 78229, United States
Pan American Center for Oncology Trials, LLC
RECRUITING

Rio Piedras, 00935, Puerto Rico
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 1Z5, Canada
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Ronald Reagan UCLA Medical Center
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Santa Monica UCLA Medical Center & Orthopaedic Hospital
NOT_YET_RECRUITING

Santa Monica, California, 90404, United States
Sarah Cannon Research Institute - Pharmacy
RECRUITING

Nashville, Tennessee, 37203, United States
Smilow Cancer Hospital - Trumbull
RECRUITING

Trumbull, Connecticut, 06611, United States
Smilow Cancer Hospital - Yale New Haven Health
RECRUITING

New Haven, Connecticut, 06510, United States
Smilow Cancer Hospital Phase 1 Unit
RECRUITING

New Haven, Connecticut, 06511, United States
The Christie NHS Foundation Trust
RECRUITING

Manchester, M20 4BX, United Kingdom
The University of Texas MD Anderson Cancer Center - Conroe
RECRUITING

Conroe, Texas, 77384, United States
The University of Texas, MD Anderson Cancer Center - League City
RECRUITING

League City, Texas, 77573, United States
The University of Texas, MD Anderson Cancer Center - Sugar Land
RECRUITING

Sugar Land, Texas, 77478, United States
The University of Texas, MD Anderson Cancer Center - West Houston
RECRUITING

Houston, Texas, 77079, United States
UCLA Department of Medicine-Hematology/Oncology
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States
UCLA Hematology/Oncology - Santa Monica
NOT_YET_RECRUITING

Santa Monica, California, 90404, United States
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Yale - New Haven Hospital - Yale Cancer Center
RECRUITING

New Haven, Connecticut, 06510, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.