New combo aims to outsmart resistant bladder cancer

NCT ID NCT06524544

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 14, 2026 · Updated 13 times

Summary

This phase III trial tests whether combining two drugs—pembrolizumab (an immunotherapy) and sacituzumab govitecan (a targeted chemotherapy)—works better than standard chemotherapy for people with advanced bladder cancer that has stopped responding to initial immunotherapy. About 320 participants will be randomly assigned to receive either the new combo or standard chemo. The main goal is to see if the combo helps people live longer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pembrolizumab and sacituzumab govitecan-hziy
What this could lead to: If it works, this combination could offer a new treatment option for people with advanced bladder cancer that no longer responds to standard immunotherapy.
What could go wrong: This is a large phase III trial, but the experimental combo may not improve survival more than standard chemotherapy, and side effects from the two drugs together could be significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bladder transitional cell carcinoma infiltrating bladder urothelial carcinoma infiltrating urothelial carcinoma transitional cell carcinoma urinary bladder carcinoma urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED UROTHELIAL CARCINOMA METASTATIC UROTHELIAL CARCINOMA UNRESECTABLE UROTHELIAL CARCINOMA

Contacts and locations

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Locations

Abbott-Northwestern Hospital
RECRUITING

Minneapolis, Minnesota, 55407, United States
Allegheny General Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Allegheny Valley Hospital
RECRUITING

Natrona Heights, Pennsylvania, 15065, United States
Avera Cancer Institute
RECRUITING

Sioux Falls, South Dakota, 57105, United States

Contact Email: •••••@•••••
Avera Cancer Institute - Mitchell
RECRUITING

Mitchell, South Dakota, 57301, United States

Contact Email: •••••@•••••
Avera Cancer Institute at Marshall
RECRUITING

Marshall, Minnesota, 56258, United States

Contact Email: •••••@•••••
Avera Cancer Institute at Pierre
RECRUITING

Pierre, South Dakota, 57501, United States

Contact Email: •••••@•••••
Avera Cancer Institute at Yankton
RECRUITING

Yankton, South Dakota, 57078, United States

Contact Email: •••••@•••••
Avera Cancer Institute-Aberdeen
RECRUITING

Aberdeen, South Dakota, 57401, United States

Contact Email: •••••@•••••
Benefis Sletten Cancer Institute
RECRUITING

Great Falls, Montana, 59405, United States

Contact Email: •••••@•••••
Billings Clinic Cancer Center
RECRUITING

Billings, Montana, 59101, United States

Contact Email: •••••@•••••
Bozeman Health Deaconess Hospital
RECRUITING

Bozeman, Montana, 59715, United States

Contact Email: •••••@•••••
Cancer Care Center of O'Fallon
RECRUITING

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur
RECRUITING

Decatur, Illinois, 62526, United States
Cancer Center at Saint Joseph's
RECRUITING

Phoenix, Arizona, 85004, United States

Contact Email: •••••@•••••
Cancer Center of Western Wisconsin
RECRUITING

New Richmond, Wisconsin, 54017, United States
Carle BroMenn Medical Center
RECRUITING

Normal, Illinois, 61761, United States

Contact Email: •••••@•••••
Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

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Carle Cancer Institute Normal
RECRUITING

Normal, Illinois, 61761, United States

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Carle Physician Group-Effingham
RECRUITING

Effingham, Illinois, 62401, United States

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Carle Physician Group-Mattoon/Charleston
RECRUITING

Mattoon, Illinois, 61938, United States

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Carle at The Riverfront
RECRUITING

Danville, Illinois, 61832, United States

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Central Vermont Medical Center/National Life Cancer Treatment
RECRUITING

Berlin Corners, Vermont, 05602, United States
Community Hospital of Anaconda
RECRUITING

Anaconda, Montana, 59711, United States

Contact Email: •••••@•••••
Community Medical Center
RECRUITING

Missoula, Montana, 59804, United States

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Community Medical Center
RECRUITING

Toms River, New Jersey, 08755, United States
Cooperman Barnabas Medical Center
RECRUITING

Livingston, New Jersey, 07039, United States
Crossroads Cancer Center
RECRUITING

Effingham, Illinois, 62401, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
RECRUITING

Lebanon, New Hampshire, 03756, United States
Decatur Memorial Hospital
RECRUITING

Decatur, Illinois, 62526, United States
Duluth Clinic Ashland
RECRUITING

Ashland, Wisconsin, 54806, United States

Contact Email: •••••@•••••
Emory Saint Joseph's Hospital
RECRUITING

Atlanta, Georgia, 30342, United States
Emory University Hospital Midtown
RECRUITING

Atlanta, Georgia, 30308, United States
Emory University Hospital/Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Essentia Health - Deer River Clinic
RECRUITING

Deer River, Minnesota, 56636, United States

Contact Email: •••••@•••••
Essentia Health Cancer Center
RECRUITING

Duluth, Minnesota, 55805, United States

Contact Email: •••••@•••••
Essentia Health Cancer Center-South University Clinic
RECRUITING

Fargo, North Dakota, 58103, United States

Contact Email: •••••@•••••
Essentia Health Hibbing Clinic
RECRUITING

Hibbing, Minnesota, 55746, United States
Essentia Health Saint Joseph's Medical Center
RECRUITING

Brainerd, Minnesota, 56401, United States

Contact Email: •••••@•••••
Essentia Health Sandstone
RECRUITING

Sandstone, Minnesota, 55072, United States

Contact Email: •••••@•••••
Essentia Health Virginia Clinic
RECRUITING

Virginia, Minnesota, 55792, United States

Contact Email: •••••@•••••
FHCC Overlake
RECRUITING

Bellevue, Washington, 98004, United States
FHCC at EvergreenHealth
RECRUITING

Kirkland, Washington, 98034, United States
FHCC at Northwest Hospital
RECRUITING

Seattle, Washington, 98133, United States
Fairview Southdale Hospital
RECRUITING

Edina, Minnesota, 55435, United States
Forbes Hospital
RECRUITING

Monroeville, Pennsylvania, 15146, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Geisinger Cancer Center Dickson City
RECRUITING

Dickson City, Pennsylvania, 18519, United States

Contact Email: •••••@•••••
Geisinger Medical Center
RECRUITING

Danville, Pennsylvania, 17822, United States

Contact Email: •••••@•••••
Geisinger Medical Oncology-Lewisburg
RECRUITING

Lewisburg, Pennsylvania, 17837, United States

Contact Email: •••••@•••••
Geisinger Wyoming Valley/Henry Cancer Center
RECRUITING

Wilkes-Barre, Pennsylvania, 18711, United States

Contact Email: •••••@•••••
Gundersen Lutheran Medical Center
RECRUITING

La Crosse, Wisconsin, 54601, United States

Contact Email: •••••@•••••
HSHS Saint Elizabeth's Hospital
RECRUITING

O'Fallon, Illinois, 62269, United States
HaysMed
RECRUITING

Hays, Kansas, 67601, United States
Hematology Oncology Associates of Fredericksburg Inc
RECRUITING

Fredericksburg, Virginia, 22408, United States
Houston Methodist Cypress Hospital
RECRUITING

Cypress, Texas, 77429, United States
Houston Methodist Hospital
RECRUITING

Houston, Texas, 77030, United States
Houston Methodist Saint John Hospital
RECRUITING

Nassau Bay, Texas, 77058, United States
Houston Methodist San Jacinto Hospital
RECRUITING

Baytown, Texas, 77521, United States
Houston Methodist Sugar Land Hospital
RECRUITING

Sugar Land, Texas, 77479, United States
Houston Methodist The Woodlands Hospital
RECRUITING

The Woodlands, Texas, 77385, United States
Houston Methodist West Hospital
RECRUITING

Houston, Texas, 77094, United States
IRMC Cancer Center
RECRUITING

Indiana, Pennsylvania, 15701, United States
Jefferson Hospital
RECRUITING

Jefferson Hills, Pennsylvania, 15025, United States
Kootenai Clinic Cancer Services - Post Falls
RECRUITING

Post Falls, Idaho, 83854, United States

Contact Email: •••••@•••••
Kootenai Clinic Cancer Services - Sandpoint
RECRUITING

Sandpoint, Idaho, 83864, United States

Contact Email: •••••@•••••
Kootenai Health - Coeur d'Alene
RECRUITING

Coeur d'Alene, Idaho, 83814, United States

Contact Email: •••••@•••••
Lawrence Memorial Hospital
RECRUITING

Lawrence, Kansas, 66044, United States
Logan Health Medical Center
RECRUITING

Kalispell, Montana, 59901, United States

Contact Email: •••••@•••••
Louisiana Hematology Oncology Associates LLC
RECRUITING

Baton Rouge, Louisiana, 70809, United States

Contact Email: •••••@•••••
Margaret R Pardee Memorial Hospital
RECRUITING

Hendersonville, North Carolina, 28791, United States

Contact Email: •••••@•••••
Mary Bird Perkins Cancer Center - Metairie
RECRUITING

Metairie, Louisiana, 70002, United States
Mary Greeley Medical Center
RECRUITING

Ames, Iowa, 50010, United States
McFarland Clinic - Ames
RECRUITING

Ames, Iowa, 50010, United States
McFarland Clinic - Boone
SUSPENDED

Boone, Iowa, 50036, United States
McFarland Clinic - Jefferson
SUSPENDED

Jefferson, Iowa, 50129, United States
McFarland Clinic - Marshalltown
RECRUITING

Marshalltown, Iowa, 50158, United States
McFarland Clinic - Trinity Cancer Center
RECRUITING

Fort Dodge, Iowa, 50501, United States
Memorial Hospital East
RECRUITING

Shiloh, Illinois, 62269, United States
Mercy Hospital
RECRUITING

Cedar Rapids, Iowa, 52403, United States
Mercy Hospital
RECRUITING

Coon Rapids, Minnesota, 55433, United States
Methodist Willowbrook Hospital
RECRUITING

Houston, Texas, 77070, United States
Missouri Baptist Medical Center
RECRUITING

St Louis, Missouri, 63131, United States
Missouri Baptist Sullivan Hospital
RECRUITING

Sullivan, Missouri, 63080, United States
Monmouth Medical Center
RECRUITING

Long Branch, New Jersey, 07740, United States
Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
Oncology Associates at Mercy Medical Center
RECRUITING

Cedar Rapids, Iowa, 52403, United States
Park Nicollet Clinic - Saint Louis Park
RECRUITING

Saint Louis Park, Minnesota, 55416, United States
Parkland Health Center - Farmington
RECRUITING

Farmington, Missouri, 63640, United States
Parkland Memorial Hospital
RECRUITING

Dallas, Texas, 75235, United States

Contact Email: •••••@•••••
Penn State Milton S Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033-0850, United States
Reading Hospital
RECRUITING

West Reading, Pennsylvania, 19611, United States
Regions Hospital
RECRUITING

Saint Paul, Minnesota, 55101, United States
Robert Wood Johnson University Hospital Somerset
RECRUITING

Somerville, New Jersey, 08876, United States
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08903, United States
Rutgers New Jersey Medical School
RECRUITING

Newark, New Jersey, 07101, United States
Saint Francis Medical Center
RECRUITING

Cape Girardeau, Missouri, 63703, United States
Saint Vincent Hospital
RECRUITING

Erie, Pennsylvania, 16544, United States
Sainte Genevieve County Memorial Hospital
RECRUITING

Sainte Genevieve, Missouri, 63670, United States
Salina Regional Health Center
RECRUITING

Salina, Kansas, 67401, United States
Siteman Cancer Center at Christian Hospital
RECRUITING

St Louis, Missouri, 63136, United States

Contact Email: •••••@•••••
Siteman Cancer Center at Saint Peters Hospital
RECRUITING

City of Saint Peters, Missouri, 63376, United States

Contact Email: •••••@•••••
Siteman Cancer Center at West County Hospital
RECRUITING

Creve Coeur, Missouri, 63141, United States

Contact Email: •••••@•••••
Siteman Cancer Center-South County
RECRUITING

St Louis, Missouri, 63129, United States

Contact Email: •••••@•••••
Southern Illinois University School of Medicine
RECRUITING

Springfield, Illinois, 62702, United States
Springfield Clinic
RECRUITING

Springfield, Illinois, 62702, United States
Springfield Memorial Hospital
RECRUITING

Springfield, Illinois, 62781, United States
Stony Brook University Medical Center
RECRUITING

Stony Brook, New York, 11794, United States
The James Graham Brown Cancer Center at University of Louisville
RECRUITING

Louisville, Kentucky, 40202, United States
The University of Kansas Cancer Center - Olathe
RECRUITING

Olathe, Kansas, 66061, United States

Contact Email: •••••@•••••
ThedaCare Regional Cancer Center
RECRUITING

Appleton, Wisconsin, 54911, United States

Contact Email: •••••@•••••
Trinity Health IHA Medical Group Hematology Oncology - Brighton
RECRUITING

Brighton, Michigan, 48114, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
RECRUITING

Canton, Michigan, 48188, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
RECRUITING

Ypsilanti, Michigan, 48197, United States
Trinity Health Saint Joseph Mercy Oakland Hospital
RECRUITING

Pontiac, Michigan, 48341, United States
Trinity Health Saint Mary Mercy Livonia Hospital
RECRUITING

Livonia, Michigan, 48154, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITING

Orange, California, 92868, United States

Contact Email: •••••@•••••
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITING

Irvine, California, 92612, United States

Contact Email: •••••@•••••
UF Health Cancer Institute - Gainesville
RECRUITING

Gainesville, Florida, 32610, United States
UMass Memorial Medical Center - University Campus
RECRUITING

Worcester, Massachusetts, 01655, United States

Contact Email: •••••@•••••
UPMC Cancer Center at UPMC Northwest
RECRUITING

Seneca, Pennsylvania, 16346, United States
UPMC Cancer Center-Uniontown
RECRUITING

Uniontown, Pennsylvania, 15401, United States
UPMC Cancer Center-Washington
RECRUITING

Washington, Pennsylvania, 15301, United States
UPMC Cancer Centers - Arnold Palmer Pavilion
RECRUITING

Greensburg, Pennsylvania, 15601, United States
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
UPMC Hillman Cancer Center - Monroeville
RECRUITING

Monroeville, Pennsylvania, 15146, United States

Contact Email: •••••@•••••
UPMC Hillman Cancer Center Erie
RECRUITING

Erie, Pennsylvania, 16505, United States

Contact Email: •••••@•••••
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
RECRUITING

Mechanicsburg, Pennsylvania, 17050, United States
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
RECRUITING

Harrisburg, Pennsylvania, 17109, United States
UPMC-Passavant Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15237, United States
UPMC-Saint Margaret
RECRUITING

Pittsburgh, Pennsylvania, 15215, United States
UT Southwestern Clinical Center at Richardson/Plano
RECRUITING

Richardson, Texas, 75080, United States
UT Southwestern Simmons Cancer Center - RedBird
RECRUITING

Dallas, Texas, 75237, United States

Contact Email: •••••@•••••
UT Southwestern/Simmons Cancer Center-Dallas
RECRUITING

Dallas, Texas, 75390, United States

Contact Email: •••••@•••••
UT Southwestern/Simmons Cancer Center-Fort Worth
RECRUITING

Fort Worth, Texas, 76104, United States

Contact Email: •••••@•••••
United Hospital
RECRUITING

Saint Paul, Minnesota, 55102, United States
University Health Truman Medical Center
RECRUITING

Kansas City, Missouri, 64108, United States
University of Illinois
RECRUITING

Chicago, Illinois, 60612, United States
University of Kansas Cancer Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Kansas Cancer Center - Briarcliff
RECRUITING

Kansas City, Missouri, 64116, United States
University of Kansas Cancer Center - Lee's Summit
RECRUITING

Lee's Summit, Missouri, 64064, United States
University of Kansas Cancer Center - North
RECRUITING

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center-Overland Park
RECRUITING

Overland Park, Kansas, 66210, United States
University of Kansas Health System Saint Francis Campus
RECRUITING

Topeka, Kansas, 66606, United States
University of Kansas Hospital-Westwood Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States
University of Michigan Health - Sparrow Lansing
RECRUITING

Lansing, Michigan, 48912, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Vermont Medical Center
RECRUITING

Burlington, Vermont, 05401, United States
University of Vermont and State Agricultural College
RECRUITING

Burlington, Vermont, 05405, United States
University of Washington Medical Center - Montlake
RECRUITING

Seattle, Washington, 98195, United States
UofL Health Medical Center Northeast
RECRUITING

Louisville, Kentucky, 40245, United States

Contact Email: •••••@•••••
VCU Massey Cancer Center at Stony Point
RECRUITING

Richmond, Virginia, 23235, United States
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Virginia Cancer Institute
RECRUITING

Richmond, Virginia, 23229, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact Email: •••••@•••••
West Penn Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
West Virginia University Charleston Division
RECRUITING

Charleston, West Virginia, 25304, United States
Wexford Health and Wellness Pavilion
RECRUITING

Wexford, Pennsylvania, 15090, United States

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