METASTATIC UROTHELIAL CARCINOMA

This is a first-in-human study testing a new oral drug called NX-1607 in adults with advanced cancers that have stopped responding to standard treatments. The main goal is to find a safe dose and see how well the body handles the drug, both alone and combined with a common chemot…

This study is checking the safety of an existing cancer drug, enfortumab vedotin, specifically for Indian adults with advanced bladder cancer that has spread and has stopped responding to standard treatments. About 100 participants will receive the drug through an IV infusion eve…

This study is testing a two-part treatment for advanced bladder cancer that has spread. First, patients receive a combination of two drugs for about 4 months. If the cancer responds well, they then continue with just one of the drugs as a long-term 'maintenance' therapy for up to…

This study is testing new combinations of cancer drugs for people with advanced bladder cancer that has spread. The first part aims to find the safest doses of two drugs. The second part will test how well these two drugs work together, and also test a three-drug combination, to …

This early-stage study is testing a new two-drug combination for people with advanced bladder cancer that has spread and is no longer responding to standard immunotherapy. The goal is to see if adding a new pill called emavusertib (CA-4948) to the existing drug pembrolizumab is s…

This early-stage study is testing a combination of two drugs, cabozantinib and enfortumab vedotin, for advanced bladder cancer that has spread. The main goal is to find the safest and most effective dose. The study will also look for early signs that the treatment can shrink tumo…

This study is for people with advanced bladder cancer that has spread and has stopped responding to a common type of immunotherapy. It compares a new two-drug combination (pembrolizumab and sacituzumab govitecan) against standard chemotherapy. The goal is to see if the new combin…

This study is testing a new, personalized vaccine designed to target the unique proteins on a patient's own cancer cells. It is being given alongside an existing immunotherapy drug (pembrolizumab) to see if the combination is safe and can help control advanced solid tumors that h…

This study is testing whether giving a cancer immunotherapy treatment called nivolumab as an injection at home is a safe and practical alternative to receiving it at a clinic. It aims to see if home treatment reduces the burden of travel and improves quality of life for patients …

This study is testing if adding a freezing procedure (cryoablation) to standard radiation therapy works better to relieve pain from cancer that has spread to the bones. Researchers will compare the combination treatment to radiation alone in 40 patients with advanced cancers. The…

This study aims to understand how kidney and bladder cancers use different nutrients from the blood to grow and survive. Researchers will study tissue samples from 600 patients who are already scheduled for surgery or biopsy for their cancer. By tracking specially labeled nutrien…

This study aims to understand how doctors decide between different first treatments for patients with advanced bladder cancer that has spread. Researchers will observe 50 patients who started treatment since October 2024, collecting information about their health characteristics …

This study aims to understand how a bladder cancer drug called enfortumab vedotin affects patients' nerves. Researchers will follow 50 adults with advanced bladder cancer who are starting this treatment. They will use nerve tests to measure changes over 12-15 weeks to learn about…