METASTATIC UROTHELIAL CARCINOMA

This early-phase trial tests a combination of two drugs, cabozantinib and enfortumab vedotin, in people with advanced bladder cancer that has spread or cannot be removed. The goal is to find the best dose and see if the combo is safe and shrinks tumors. About 32 adults who have a…

This study is for people with metastatic urothelial cancer, a type of bladder cancer that has spread. It tests two antibody-drug conjugates (sacituzumab govitecan and enfortumab vedotin) with or without the immunotherapy pembrolizumab. The goal is to find the safest doses and see…

This study tests a personalized vaccine made from a patient's own tumor proteins, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors. The goal is to see if this combination is safe and helps the immune system fight cancer more effectively. A…

This early-phase study tests an experimental pill called NX-1607 in adults with advanced cancers that have not responded to standard treatments. The drug aims to boost the body's immune system to fight tumors. The main goals are to check safety and see if the drug can shrink or c…

This phase 3 trial tests whether combining two drugs—pembrolizumab (an immunotherapy) and sacituzumab govitecan (a targeted chemo)—works better than standard chemotherapy for people with advanced bladder cancer that no longer responds to initial immunotherapy. About 320 adults wi…

This early-stage trial tests a new treatment made from donor immune cells (CAR-NK cells) designed to attack two targets on bladder cancer cells. It is for adults with advanced bladder cancer that has not responded to standard therapies. The main goals are to check safety and see …

This study tests a two-step treatment for people with advanced bladder cancer that has spread. First, patients receive a combination of two drugs (enfortumab vedotin and pembrolizumab) for 18 weeks. Then, those who respond well continue with just pembrolizumab for up to 2 years t…

This early-stage trial tests a new drug combination (emavusertib plus pembrolizumab) in 27 adults with advanced bladder cancer that no longer responds to standard immunotherapy. The goal is to find a safe dose and see if the combo can shrink tumors or slow the cancer's growth. Pa…

This study is for Indian adults with advanced or metastatic urothelial cancer (bladder cancer that has spread). The main goal is to confirm the safety of the drug enfortumab vedotin. Participants will receive the drug through an IV infusion every 28 days. The study will monitor f…

This study looks at whether giving the cancer drug nivolumab as a shot at home is as good as getting it at the clinic. About 50 adults with various cancers will try both ways to see which they prefer and how it affects their quality of life. The goal is to reduce the time, cost, …

This early-stage study tests an experimental drug called GB-4362 given alongside two standard cancer treatments for advanced bladder cancer. The goal is to see if GB-4362 is safe and can reduce nerve damage and other side effects caused by the chemotherapy. About 37 adults with a…

This study tests whether freezing bone tumors (cryoablation) before giving radiation therapy works better than radiation alone for reducing pain. About 40 adults with cancer that has spread to the bones will be enrolled. The goal is to see if the combination provides more complet…

This study looks at 50 adults with metastatic bladder cancer who started first-line treatment after October 2024. Researchers want to understand why some patients receive platinum-based chemotherapy instead of the newer combination of Enfortumab Vedotin and Pembrolizumab. No new …

This study looks at how a drug called enfortumab vedotin affects the nerves of people with advanced bladder cancer that has spread. Researchers will measure nerve function with simple tests before and during treatment. The goal is to better understand and possibly prevent nerve d…

This study looks at how kidney and bladder cancers use nutrients like sugar and fat to grow. About 600 adults having surgery or a biopsy will receive a special nutrient tracer through an IV. Blood and tissue samples are then analyzed to see how the cancer uses these fuels. Partic…