New bladder cancer therapy shows promise in early trial

NCT ID NCT05951179

Recruiting now Disease control Sponsor: Protara Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 01, 2026 · Updated 3 times

Summary

This phase 2 study is testing a new treatment called TARA-002 for people with a type of high-grade bladder cancer that hasn't spread into the muscle. The treatment is given directly into the bladder through a catheter once a week for 6 weeks. The study will include about 131 adults, some who have had prior BCG therapy and some who haven't. The main goal is to see if TARA-002 can make the cancer disappear completely.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TARA-002 (a bacterial-based therapy given directly into the bladder)
What this could lead to: If successful, this could offer a new treatment option for people with high-grade bladder cancer that hasn't spread into the muscle, potentially helping to control the disease without needing to remove the bladder.
What could go wrong: This is a phase 2 trial, so it's still early. The treatment may not work for everyone, and side effects from the bladder instillations are possible. Results need to be confirmed in larger studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bladder carcinoma in situ in situ carcinoma non-invasive bladder urothelial carcinoma Non-Muscle Invasive Bladder Neoplasms Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-MUSCLE INVASIVE BLADDER CANCER

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

AccuMed Research Associates
TERMINATED

Garden City, New York, 11530, United States
Advanced Urology
RECRUITING

Lakewood, Colorado, 80228, United States
AdventHealth Medical Group Urology of Denver
RECRUITING

Denver, Colorado, 80211, United States
Amarillo Urology Research
WITHDRAWN

Amarillo, Texas, 79106, United States
Arensia Kapitanivka - PPDS
RECRUITING

Kapitanivka, 08111, Ukraine
Arkansas Urology
RECRUITING

Little Rock, Arkansas, 72211, United States
Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
CEMAIC
RECRUITING

Córdoba, X5088, Argentina
Carolina Urologic Research Center
RECRUITING

Myrtle Beach, South Carolina, 29572, United States
Centro Argentino de Urologia
RECRUITING

CABA, C1419, Argentina
Centro Urologico Profesor Bengio SA
RECRUITING

Córdoba, X5000KPH, Argentina
Centro de Urologia Avancada
RECRUITING

Porto Alegre, Rio Grande do Sul, 91350-200, Brazil
Clinica Privada Independencia
RECRUITING

Munro, 1605, Argentina
Clinical Trial Network
WITHDRAWN

Houston, Texas, 77074, United States
Colorado University - Anshutz
RECRUITING

Aurora, Colorado, 80045, United States
Comprehensive Urologic Care
RECRUITING

Lake Barrington, Illinois, 60010, United States
Conrad Person Clinic
RECRUITING

Memphis, Tennessee, 38128, United States
East Valley Urology Center of Arizona
RECRUITING

Queen Creek, Arizona, 85140, United States
Exdeo Clinical Research Inc
TERMINATED

Abbotsford British Columbia, British Columbia, V2T 1X8, Canada
Faculdade de Medicina ABC-CEPHO
RECRUITING

Santo André, São Paulo, 09060-650, Brazil
Fuji City General Hospital
RECRUITING

Sakura-shi, Chiba, 285-8741, Japan
Genesis Research
WITHDRAWN

San Diego, California, 92123, United States
Genesis Research LLC
RECRUITING

Torrance, California, 90505, United States
Hitachi General Hospital
RECRUITING

Hitachi-shi, Ibaraki, 317-0077, Japan
Hospital Britanico de Buenos Aires
RECRUITING

Buenos Aires, C1280, Argentina
Hospital Italiano de Buenos Aires (HIBA)
RECRUITING

Buenos Aires, C1199ABB, Argentina
Hospital Sirio Libanes
RECRUITING

CABA, C1419, Argentina
Hospital de Clinicas da UNICAMP
RECRUITING

Campinas, São Paulo, 13083-970, Brazil
Houston Methodist Hospital
RECRUITING

Houston, Texas, 77030, United States
Houston Metro Urology
RECRUITING

Houston, Texas, 77027, United States
Hyogo Prefectural Amagasaki General Medical Center
RECRUITING

Amagasaki-shi, Hyōgo, 660-8550, Japan
Instituto Dor de Pesquisa e Ensino
RECRUITING

Jardim Paulista, São Paulo, 01401-002, Brazil
Japanese Red Cross Aichi Medical Center Nayoya Daiichi
RECRUITING

Nagoya, Aichi-ken, 435-8511, Japan
Japanese Red Cross Osaka Hospital
RECRUITING

Osaka, Osaka, 543-855, Japan
Jonathan Giddes Medicine Professional Corporation
WITHDRAWN

Brampton, Ontario, L6T 4S5, Canada
Komaki City Hospital
RECRUITING

Komaki-shi, Aichi-ken, 485-0044, Japan
Kyushu University Hospital
RECRUITING

Nova Lima, Minas Gerais, 34006-059, Brazil
Kyushu University Hospital
RECRUITING

Fukuoka, Fukuoka, 812-8582, Japan
Laura & Isaac Perlmutter Cancer Center - NYU Langone Health
RECRUITING

New York, New York, 10016, United States
Mayo Clinic
RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Michael Oefelein Clinical Trials
RECRUITING

Bakersfield, California, 93301, United States
Minnesota Urology, Woodbury
RECRUITING

Bloomington, Minnesota, 55425, United States
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10467, United States
Niigata Cancer Center Hospital
RECRUITING

Niigata, Niigata, 961-8566, Japan
Nucleo de Pesquisa Clinica do Rio Grande so Sul
RECRUITING

Porto Alegre, Rio Grande do Sul, 90430-001, Brazil
Ochsner Health LSU - Regional Urology
WITHDRAWN

Shreveport, Louisiana, 71105, United States
Office of Lucas Nougeria MA
RECRUITING

Nova Lima, Minas Gerais, 34006-059, Brazil
Renown Regional Medical Center
RECRUITING

St Louis, Missouri, 63110, United States
Santa Casa de Misericordia de Porto Alegre
RECRUITING

Porto Alegre, Rio Grande do Sul, 90035-070, Brazil
Southern Urology
RECRUITING

Lafayette, Louisiana, 70508, United States
Specialty Clinic Research of St. Louis
RECRUITING

St Louis, Missouri, 63141, United States
Spokane Urology
RECRUITING

Spokane, Washington, 99202, United States
Sunnybrook Research Institute
WITHDRAWN

Toronto, Ontario, M4N 3M5, Canada
Toho University Medical Center Sakura Hospital
RECRUITING

Fuji-shi, Shizuoka, 417-8567, Japan
Toyama University Hospital
RECRUITING

Toyama, Toyama, 930-0152, Japan
UHN Princess Margaret Cancer Centre Princess Margaret Hospital
RECRUITING

Toronto, Ontario, M5G 1Z5, Canada
UT Health San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
University of California Irvine Medical Center
RECRUITING

Orange, California, 92697, United States
University of Florida Health Jacksonville
WITHDRAWN

Gainesville, Florida, 32611, United States
University of Pittsburgh Medical Center
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of Rochester, Department of Urology
RECRUITING

Rochester, New York, 14642, United States
University of Toledo
WITHDRAWN

Toledo, Ohio, 43606, United States
Urology Associates PC
RECRUITING

Nashville, Tennessee, 37209, United States
Urology Associates of Denver
RECRUITING

Lone Tree, Colorado, 80124, United States
Urology Austin, LLC
RECRUITING

Austin, Texas, 78745, United States
Urology Centers of Alabama
RECRUITING

Homewood, Alabama, 35209, United States
Urology Group of Southern California
TERMINATED

Los Angeles, California, 90017, United States
Urology Partners of North Texas
RECRUITING

Arlington, Texas, 76017, United States
Virginia Urology
RECRUITING

Richmond, Virginia, 23235, United States

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