New bladder cancer combo aims to help patients who Can't take chemo
NCT ID NCT06394570
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests a combination of the drug enfortumab vedotin and radiation therapy given before surgery for muscle-invasive bladder cancer. It is for patients who cannot receive standard cisplatin chemotherapy. The trial will test three different schedules of the drug and radiation to find the safest and most effective approach. Nineteen participants will be enrolled, and the main goal is to see how many have no cancer left in the bladder at the time of surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Enfortumab vedotin (a drug that targets cancer cells) and radiation therapy
What this could lead to
If successful, this could offer a new treatment option for muscle-invasive bladder cancer patients who cannot receive standard chemotherapy, potentially improving outcomes before surgery.
What could go wrong
This is a very early phase 1/2 trial with only 19 participants, so results may not apply to everyone. The combination of drug and radiation may cause side effects, and it is not yet known if it works better than current treatments.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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UT Southwestern Medical Center
RECRUITINGDallas, Texas, 75390, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact