New bladder cancer combo aims to help patients who Can't take chemo

NCT ID NCT06394570

Recruiting now Disease control Sponsor: University of Texas Southwestern Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests a combination of the drug enfortumab vedotin and radiation therapy given before surgery for muscle-invasive bladder cancer. It is for patients who cannot receive standard cisplatin chemotherapy. The trial will test three different schedules of the drug and radiation to find the safest and most effective approach. Nineteen participants will be enrolled, and the main goal is to see how many have no cancer left in the bladder at the time of surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Enfortumab vedotin (a drug that targets cancer cells) and radiation therapy
What this could lead to: If successful, this could offer a new treatment option for muscle-invasive bladder cancer patients who cannot receive standard chemotherapy, potentially improving outcomes before surgery.
What could go wrong: This is a very early phase 1/2 trial with only 19 participants, so results may not apply to everyone. The combination of drug and radiation may cause side effects, and it is not yet known if it works better than current treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

infiltrating bladder urothelial carcinoma urinary bladder carcinoma Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLADDER CANCER

Contacts and locations

Locations

UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States

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