Bladder cancer virus therapy shows promise in Mid-Stage trial

NCT ID NCT06567743

Recruiting now Disease control Sponsor: CG Oncology, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial tests a drug called cretostimogene grenadenorepvec in 325 people with high-risk non-muscle-invasive bladder cancer. The drug is a virus that is put directly into the bladder to attack cancer cells. The study looks at how well it works and how safe it is, including when used alone or with another drug called gemcitabine.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cretostimogene grenadenorepvec (a virus-based therapy given directly into the bladder)
What this could lead to: If successful, this could offer a new treatment option for high-risk bladder cancer that avoids or delays bladder removal surgery.
What could go wrong: This is a Phase 2 trial, so it's still early. The therapy may not work for everyone, and side effects from the virus or combination with other drugs are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

superficial urinary bladder carcinoma Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIGH-RISK NON-MUSCLE INVASIVE BLADDER CANCER

Contacts and locations

Locations

Adult and Adolescent Urology
RECRUITING

Omaha, Nebraska, 68114, United States
Advanced Urology
WITHDRAWN

Los Angeles, California, 90045, United States
Advanced Urology Institute
RECRUITING

Oxford, Florida, 34484, United States
Advanced Urology Institute (Solaris)
RECRUITING

Largo, Florida, 33771, United States
Advanced Urology Institute - Tallahassee (Solaris)
WITHDRAWN

Tallahassee, Florida, 32308, United States
Amarillo Urology Research
COMPLETED

Amarillo, Texas, 79106, United States
Anne Arundel Urology
RECRUITING

Annapolis, Maryland, 21401, United States
Arizona Urology Specialty
WITHDRAWN

Tucson, Arizona, 85704, United States
Arkansas Urology
RECRUITING

Little Rock, Arkansas, 72211, United States
Associated Medical Professionals of NY, PLLC (US Urology Partners)
RECRUITING

Syracuse, New York, 13210, United States
Associated Urological Specialists
RECRUITING

Chicago Ridge, Illinois, 60415, United States
Carolina Urologic Research Center, LLC
RECRUITING

Myrtle Beach, South Carolina, 229572, United States
Central Ohio Urology Group (US Urology Partners)
RECRUITING

Gahanna, Ohio, 43230, United States
Charleston Area Medical Center
RECRUITING

Charleston, South Carolina, 25304, United States
Chesapeake Urology Research Associates
RECRUITING

Hanover, Maryland, 21076, United States
Colorado Urology
RECRUITING

Lakewood, Colorado, 80228, United States
Comprehensive Urology
RECRUITING

Royal Oak, Michigan, 48073, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
First Urology, PSC
RECRUITING

Jeffersonville, Indiana, 47130, United States
Genesis Research (Greater Los Angeles)
RECRUITING

Los Alamitos, California, 90720, United States
Genesis Research (Greater Los Angeles)
RECRUITING

Torrance, California, 90503, United States
Houston Methodist
RECRUITING

Houston, Texas, 77030, United States
Integrated Medical Professionals, PLLC (Solaris)
RECRUITING

New York, New York, 10016, United States
Keystone Urology Specialists
RECRUITING

Lancaster, Pennsylvania, 17604, United States
Lowcountry Urology (Solaris)
RECRUITING

North Charleston, South Carolina, 29406, United States
Mayo Clinic Arizona
RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic Florida
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Michael G Oefelein, MD Clinical Trials
RECRUITING

Bakersfield, California, 93301, United States
Michigan Institute of Urology (Solaris)
RECRUITING

Troy, Michigan, 48084, United States
Midlantic Urology (Solaris)
RECRUITING

Bala-Cynwyd, Pennsylvania, 19004, United States
Minnesota Urology
RECRUITING

Woodbury, Minnesota, 55123, United States
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10461, United States
Ochsner Medical Center
RECRUITING

New Orleans, Louisiana, 70121, United States
Om research
RECRUITING

San Diego, California, 91223, United States
Oregon Urology Institute
RECRUITING

Springfield, Oregon, 97447, United States
Penn State University Milton S. Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033, United States
SUNY Upstate
RECRUITING

Syracuse, New York, 13202, United States
Southern Urology (Urology America)
RECRUITING

Lafayette, Louisiana, 70508, United States
Specialty Clinical Research of St. Louis
RECRUITING

St Louis, Missouri, 63141, United States
Spokane Urology
RECRUITING

Spokane, Washington, 99202, United States
The Conrad Pearson Clinic (Urology America)
RECRUITING

Germantown, Tennessee, 38138, United States
The Urology Group (Solaris)
RECRUITING

Cincinnati, Ohio, 45212, United States
UPNT Research Institute, LLC
RECRUITING

Arlington, Texas, 76017, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University of Arkansas for Medical Sciences
RECRUITING

Little Rock, Arkansas, 72205, United States
University of California, Irvine
RECRUITING

Orange, California, 92868, United States
University of Cincinnati Cancer Center
RECRUITING

Cincinnati, Ohio, 45267, United States
University of Florida
RECRUITING

Gainesville, Florida, 32611, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Rochester
RECRUITING

Rochester, New York, 14620, United States
University of Southern California
RECRUITING

San Diego, California, 92123, United States
Urologic Specialists of Northwest Indiana (Solaris)
RECRUITING

Merrillville, Indiana, 46410, United States
Urology Associates, Lone Tree
RECRUITING

Lone Tree, Colorado, 80124, United States
Urology Associates, PC
RECRUITING

Nashville, Tennessee, 37209, United States
Urology Austin, PLLC (Urology America)
RECRUITING

Austin, Texas, 78745, United States
Urology Center of Iowa Research
RECRUITING

Clive, Iowa, 50325, United States
Urology Center of Southern California
RECRUITING

Murrieta, California, 92563, United States
Urology Clinics of North Texas, PLLC
RECRUITING

Dallas, Texas, 75231, United States
Urology San Antonio, PA dba USA Clinical Trials
RECRUITING

San Antonio, Texas, 78229, United States
Urology of Indiana - Carmel
RECRUITING

Carmel, Indiana, 46032, United States
Urology of Indiana, LLC (US Urology Partners)
RECRUITING

Greenwood, Indiana, 46143, United States
Urology of Virginia
RECRUITING

Virginia Beach, Virginia, 23462, United States
Uropartners
RECRUITING

Glenview, Illinois, 60026, United States
Wichita Urology Group
RECRUITING

Wichita, Kansas, 67226, United States

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