New Gene-Based bladder cancer treatment shows promise in early trial

NCT ID NCT04752722

Recruiting now Disease control Sponsor: enGene, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This study tests a new drug called EG-70 (detalimogene) for a type of bladder cancer called non-muscle invasive bladder cancer (NMIBC). The drug is given directly into the bladder through a catheter. The trial includes patients whose cancer did not respond to standard BCG therapy, as well as some high-risk patients who haven't had full BCG treatment. The goal is to see if EG-70 is safe and can shrink or eliminate tumors, potentially offering an alternative to bladder removal surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: EG-70 (detalimogene)
What this could lead to: If successful, this could offer a new treatment option for bladder cancer patients who don't respond to standard BCG therapy, potentially avoiding bladder removal surgery.
What could go wrong: This is an early-phase trial (Phase 1/2) with a small number of patients initially, so safety and effectiveness are not yet proven. The treatment requires multiple bladder instillations and may cause side effects.

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Conditions

The condition(s) this trial relates to.

bladder carcinoma in situ in situ carcinoma non-invasive bladder urothelial carcinoma Non-Muscle Invasive Bladder Neoplasms superficial urinary bladder carcinoma Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-MUSCLE INVASIVE BLADDER CANCER NON-MUSCLE INVASIVE BLADDER CANCER WITH CARCINOMA IN SITU SUPERFICIAL BLADDER CANCER

Contacts and locations

Locations

Albany Medical College
RECRUITING

Albany, New York, 12208, United States
Arkansas Urology
RECRUITING

Little Rock, Arkansas, 72211, United States
Associated Medical Professionals of NY,
RECRUITING

Syracuse, New York, 13210, United States
Associated Urologists of North Carolina
RECRUITING

Raleigh, North Carolina, 27612, United States
Azienda Ospedaliero-Universitaria Sant'Andrea
RECRUITING

Rome, 00189, Italy
Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 45227, United States
CHU Bordeaux Pellegrin
RECRUITING

Bordeaux, 33076, France
CHU d'Angers
RECRUITING

Angers, 49933, France
CHU de Lille
RECRUITING

Lille, 59000, France
CHU de Rauen- Hopital Charles Nicolle
RECRUITING

Rouen, 76031, France
CHUM Centre Hospitalier de l Universite de Montreal
RECRUITING

Montreal, Quebec, Canada
Carolina Urologic Research Center, LLC
RECRUITING

Myrtle Beach, South Carolina, 29572, United States
Central Ohio Urology Group
RECRUITING

Gahanna, Ohio, 43230, United States
Chesapeake Urology Research Associates
RECRUITING

Hanover, Maryland, 21076, United States
Chi Mei Medical Center
RECRUITING

Tainan, 71004, Taiwan
China Medical University Hospital
RECRUITING

Taichung, 40447, Taiwan
Chonnam National University Hwasun Hospital
RECRUITING

Hwasun, Jeollanam-do, 58128, South Korea
Clinic Unit of Urology, IRCCS Ospedale San Raffaele
RECRUITING

Milan, MI, 20132, Italy
Clinical Research Solutions - Helios Clinical Research
RECRUITING

Middleburg Heights, Ohio, 44130, United States
Colorado Clinical Research
RECRUITING

Lakewood, Colorado, 80228, United States
Corewell Health Medical Group and Spectrum Health Hospitals
RECRUITING

Grand Rapids, Michigan, 49503, United States
Duke Health - Duke Cancer Center
RECRUITING

Durham, North Carolina, 27710, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Fondazione Policlinico Universitario "A.Gemelli" IRCCS, Largo
RECRUITING

Rome, 00168, Italy
Froedtert Hospital / Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 52336, United States
Fundacio Puigvert
RECRUITING

Barcelona, 08025, Spain
Georgia Cancer Center at Augusta University
RECRUITING

Augusta, Georgia, 30912, United States
Gold Coast University Hospital
RECRUITING

Southport, Queensland, 4215, Australia
Henry Ford Health System
RECRUITING

Detroit, Michigan, 48202, United States
Hopital Bichat Claude-Bernard
RECRUITING

Paris, 75018, France
Hospices Civils de Lyon
RECRUITING

Lyon, 69002, France
Hospital Clinic Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital General Universitario Gregorio Maranon
RECRUITING

Madrid, 28007, Spain
Hospital General Universitario Morales Meseguer
RECRUITING

Murcia, 30008, Spain
Hospital Germans Trias i Pujol
RECRUITING

Barcelona, 08916, Spain
Hospital Quironsalud Madrid (Next Oncology)
RECRUITING

Madrid, 28223, Spain
Hospital Universitari de Bellvitge
RECRUITING

L'Hospitalet de Llobregat, 08907, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Infanta Sofia
RECRUITING

Madrid, 28702, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Marqués de Valdecilla,
RECRUITING

Santander, 39008, Spain
Houston Methodist Hospital - Department of Urology
RECRUITING

Houston, Texas, 77030, United States
Houston Metro Urology
RECRUITING

Houston, Texas, 77027, United States
Huntsman Cancer Institute, University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
IOB - Hospital Quironsalud Barcelona
RECRUITING

Barbera Del Valles, 5-7, Spain
Icon Cancer Center Windsor Gardens
RECRUITING

Windsor Gardens, South Australia, 5087, Australia
Istituto Europeo di Oncologia
RECRUITING

Milan, 20141, Italy
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale
RECRUITING

Naples, 80131, Italy
John Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21287, United States
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 807, Taiwan
Klinik fur Urologie, Uro-Onkologie, spezielle urologische und Roboter-assistierte Chirurgie Universitatsklinikum Koln (AOR)
RECRUITING

Cologne, 50937, Germany
Laura & Isaac Perlmutter Cancer Center at NYU Langone Health
COMPLETED

New York, New York, 10016, United States
Mayo Clinic
RECRUITING

Scottsdale, Arizona, 85259, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
McGill University Health Center - Glen site
RECRUITING

Montreal, Quebec, H4A3J1, Canada
Mount Sinai Medical Center
RECRUITING

New Haven, New York, 10029, United States
National Taiwan University Hospital
RECRUITING

Taipei, 100, Taiwan
New Jersey Urology, LLC
RECRUITING

Voorhees Township, New Jersey, 08043, United States
Nova Scotia Health Authority
RECRUITING

Halifax, Nova Scotia, B3H2Y9, Canada
Om Research
RECRUITING

San Diego, California, 92123, United States
Oregon Health & Science University (OHSU)
RECRUITING

Portland, Oregon, 97239, United States
Ospedelae Molinette San Giovanni Battista Di Torino
RECRUITING

Torino, 10126, Italy
Prostate Cancer Centre
RECRUITING

Calgary, Alberta, T2V1P9, Canada
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08901, United States
Seoul National University Bundang Hospital
RECRUITING

Seongnam, Gyunggi-do, 13620, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Studienpraxis Urologie
RECRUITING

Nürtingen, 72622, Germany
Sydney Adventist Hospital
RECRUITING

Wahroonga, New South Wales, 2076, Australia
Sylvester Comprehensive Cancer Center / University of Miami Hospital and Clinics
RECRUITING

Miami, Florida, 33136, United States
Taichung Veterans General Hospital
RECRUITING

Taichung, 40705, Taiwan
The Catholic University of Korea, Soul St. Mary's Hospital
RECRUITING

Seoul, 06591, South Korea
The George Washington Medical Faculty Associates
RECRUITING

Washington D.C., District of Columbia, 20037, United States
The Royal Marsden NHS Foundation Trust
RECRUITING

London, SW3 6JJ, United Kingdom
The University of Alabama at Birmingham Clinical Research Unit (CRU)
RECRUITING

Birmingham, Alabama, 35249, United States
Thomas Jefferson University, Sidney Kimmel Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Tower Urology
RECRUITING

Los Angeles, California, 90048, United States
UC San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92037, United States
UNC Chapel Hill Hospital
RECRUITING

Chapel Hill, North Carolina, 27514, United States
UOC Urologia, IFO- lstituto Tumori "Regina Elena"
RECRUITING

Rome, 53 00144, Italy
USC/Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
Universitaetsklinikum Erlangen
RECRUITING

Erlangen, 91054, Germany
Universitaetsklinikum Tubingen
RECRUITING

Tübingen, 72076, Germany
University Health Network, Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
University of California - Irvine Medical Center
RECRUITING

Irvine, California, 92697, United States
University of Cincinnati Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States
University of Florida
RECRUITING

Jacksonville, Florida, 32209, United States
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Texas - MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
University of Virginia Comprehensive Cancer Center
RECRUITING

Charlottesville, Virginia, 22903, United States
Urological Associates of South Arizona
COMPLETED

Tucson, Arizona, 85715, United States
Urologicum Duisburg
RECRUITING

Duisburg, 47169, Germany
Urologie Neandertal Mettmann
RECRUITING

Mettmann, 40822, Germany
Urology Associates, P.C.
RECRUITING

Nashville, Tennessee, 37209, United States
Urology Austin
RECRUITING

Austin, Texas, 78745, United States
Urology of Indiana
RECRUITING

Greenwood, Indiana, 46143, United States
Vancouver Prostate Centre
RECRUITING

Vancouver, British Columbia, V5Z1M9, Canada
Vanderbilt Univerity Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
lnstitut Bergonie 229 Cour de l'Argonne
RECRUITING

Bordeaux, 33076, France

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