Urine test could spare bladder cancer patients from painful scopes

NCT ID NCT05796375

Recruiting now Diagnosis Sponsor: White River Junction Veterans Affairs Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 06, 2026 · Updated 3 times

Summary

This study tests whether a simple urine test (Bladder EpiCheck) can safely replace some of the invasive cystoscopy procedures used to monitor non-muscle invasive bladder cancer. About 240 adults with low-grade intermediate-risk bladder cancer will be followed to compare quality of life, discomfort, anxiety, and cancer outcomes between those who get standard cystoscopies and those who get urine tests instead. The goal is to see if monitoring can be made less burdensome without missing cancer recurrences.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Bladder EpiCheck urine test
What this could lead to: If successful, this could make bladder cancer monitoring less invasive and more comfortable, reducing the need for frequent cystoscopies.
What could go wrong: This is a Phase 2 trial with 240 participants, so results are preliminary. The urine test may not catch all recurrences, and some cystoscopies may still be needed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm non-invasive bladder urothelial carcinoma Non-Muscle Invasive Bladder Neoplasms superficial urinary bladder carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-MUSCLE INVASIVE BLADDER CANCER

Contacts and locations

Locations

Bay Pines VA Healthcare System
RECRUITING

Bay Pines, Florida, 33744, United States
Dartmouth Hitchcock Medical Center
RECRUITING

Lebanon, New Hampshire, 03756, United States
James A. Haley Veterans' Hospital
RECRUITING

Tampa, Florida, 33612, United States
Medical University of South Carolina
ACTIVE_NOT_RECRUITING

Charleston, South Carolina, 29425, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75235, United States
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
VA Boston Jamaica Plains Campus
RECRUITING

West Roxbury, Massachusetts, 02132, United States
VA St.Louis Healthcare System
RECRUITING

St Louis, Missouri, 63016, United States
West Haven VA Medical Center
RECRUITING

West Haven, Connecticut, 06516, United States
White River Junction Veterans Healthcare System
RECRUITING

White River Junction, Vermont, 05009, United States

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