Can a Two-Drug cocktail keep bladder cancer from coming back?

NCT ID NCT07720284

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This phase 3 trial is testing whether a combination of two drugs—datopotamab deruxtecan and rilvegostomig—given after surgery can prevent cancer recurrence in people with high-risk muscle invasive bladder cancer. Participants who have had their tumor completely removed will receive either the drug combo or standard care. The study aims to see if the combination improves how long people stay cancer-free.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a combination of two drugs: datopotamab deruxtecan (an antibody-drug conjugate targeting TROP2) and rilvegostomig (a bispecific antibody)
What this could lead to: If successful, this combination could offer a new option to reduce the risk of cancer returning after surgery for people with high-risk bladder cancer.
What could go wrong: This is an early-stage test of a new combination; side effects from the drugs could be significant, and it may not prove more effective than current standard treatments.

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Conditions

The condition(s) this trial relates to.

carcinoma infiltrating bladder urothelial carcinoma transitional cell carcinoma Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIGH-RISK MUSCLE INVASIVE UROTHELIAL CARCINOMA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

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Hot Springs, Arkansas, 71913, United States
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Little Rock, Arkansas, 72205, United States
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Little Rock, Arkansas, 72211, United States
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San Francisco, California, 94143, United States
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Chicago, Illinois, 60637, United States
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Boston, Massachusetts, 02215, United States
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Kansas City, Missouri, 64132, United States
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Lincoln, Nebraska, 68506, United States
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Omaha, Nebraska, 68130, United States
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Albany, New York, 12208, United States
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New York, New York, 10065, United States
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Cleveland, Ohio, 44195, United States
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Myrtle Beach, South Carolina, 29572, United States
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Nashville, Tennessee, 37203, United States
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Dallas, Texas, 75235, United States
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Falls Church, Virginia, 22042, United States
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Seattle, Washington, 98109, United States
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Tacoma, Washington, 98405, United States
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Milwaukee, Wisconsin, 53226, United States
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Auchenflower, 4066, Australia
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Ballarat, 3350, Australia
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Clayton, 3168, Australia
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Darlinghurst, 2010, Australia
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Elizabeth Vale, 5112, Australia
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South Brisbane, 4101, Australia
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St Albans, 3021, Australia
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Barretos, 14784-400, Brazil
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Curitiba, 81520-060, Brazil
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Salvador, 41950-640, Brazil
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São Paulo, 01323-903, Brazil
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São Paulo, 05652-900, Brazil
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Calgary, Alberta, T2N 5G2, Canada
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Abbotsford British Columbia, British Columbia, V2S0C2, Canada
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Barrie, Ontario, L4M 6M2, Canada
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Hamilton, Ontario, L8V 5C2, Canada
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Kingston, Ontario, K7L 2V7, Canada
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London, Ontario, N6C 2R5, Canada
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Mississauga, Ontario, L5M 2N1, Canada
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Montreal, Quebec, H2X 0A9, Canada
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Montreal, Quebec, H3A 1A1, Canada
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Beijing, 100034, China
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Beijing, 100050, China
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Beijing, 100191, China
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Changsha, 410013, China
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Chengdu, 610000, China
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Chengdu, 610072, China
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Chongqing, 400016, China
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Chongqing, 400030, China
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Fuzhou, 350005, China
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Guangzhou, 510220, China
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Guangzhou, 510288, China
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Guiyang, 550044, China
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Hangzhou, 310003, China
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Hangzhou, 310009, China
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Harbin, 150049, China
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Jinan, 250012, China
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Jinan, 250021, China
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Kunming, 650101, China
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Kunming, 650118, China
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Lanzhou, 730030, China
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Nanchang, 330006, China
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Nanjing, 210008, China
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Nanning, 530021, China
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Ningbo, 315010, China
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Qingdao, 266003, China
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Shanghai, 200040, China
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Shenyang, 110004, China
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Shenyang, 110042, China
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Suining Shi, 629000, China
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Tianjin, 300211, China
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Wenzhou, 325000, China
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Wuhan, 430022, China
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Wuhan, 430030, China
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Xuzhou, 221000, China
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Zhengzhou, 450008, China
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Bordeaux, 33000, France
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Montpellier, 34298, France
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Paris, 75014, France
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Pierre-Bénite, 69310, France
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Poitiers, 86000, France
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Strasbourg, 67098, France
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Bochum, 44791, Germany
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Bonn, 53127, Germany
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Dresden, 01307, Germany
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Duisburg, 47169, Germany
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Frankfurt am Main, 60431, Germany
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Hamburg, 20246, Germany
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Hanover, 30625, Germany
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Herne, 44625, Germany
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Magdeburg, 39120, Germany
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Mannheim, 68167, Germany
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Marburg, 35043, Germany
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Mettmann, 40822, Germany
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Münster, 48149, Germany
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Nuremberg, 90419, Germany
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Nürtingen, 72622, Germany
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Regensburg, 93053, Germany
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Rostock, 18057, Germany
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Stuttgart, 70174, Germany
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Tübingen, 72076, Germany
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Ulm, 89081, Germany
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Kolkata, 700160, India
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Kottayam, 686008, India
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Nashik, 422011, India
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Navi Mumbai, 410210, India
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New Delhi, 110076, India
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New Delhi, 110085, India
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New Delhi, 11029, India
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Bari, 70120, Italy
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Florence, 50134, Italy
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Padova, 35128, Italy
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Roma, 00168, Italy
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Rozzano, 20089, Italy
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Tricase, 73039, Italy
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Fukuoka, 811-1347, Japan
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Fukuoka, 812-8582, Japan
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Hamamatsu, 431-3192, Japan
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Hirosaki-shi, 036-8563, Japan
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Kanazawa, 920-8641, Japan
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Kashihara-shi, 634-8522, Japan
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Kawasaki-shi, 216-8511, Japan
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Kita-gun, 761-0793, Japan
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Kobe, 650-0017, Japan
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Kōtoku, 135-8550, Japan
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Kumamoto, 860-0008, Japan
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Nagasaki, 852-8501, Japan
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Nagoya, 466-8560, Japan
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Osaka, 541-8567, Japan
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Osaka, 545-8586, Japan
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Toyama, 930-0194, Japan
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Tsukuba, 305-8576, Japan
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Gdansk, 80-952, Poland
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Koszalin, 75-581, Poland
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Poznan, 61-731, Poland
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Siedlce, 08-110, Poland
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Skórzewo, 60-185, Poland
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Wroclaw, 50-556, Poland
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Wroclaw, 53-413, Poland
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Seoul, 03080, South Korea
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Seoul, 06591, South Korea
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Seoul, 3722, South Korea
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Seoul, 5505, South Korea
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Seoul, 6351, South Korea
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L'Hospitalet de Llobregat, 08908, Spain
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Las Palmas de Gran Canaria, 35016, Spain
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Madrid, 28040, Spain
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Santander, 39008, Spain
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Seville, 41013, Spain
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Kaohsiung City, 80756, Taiwan
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Kaohsiung City, 813, Taiwan
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Kaohsiung City, 83301, Taiwan
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Tainan, 704, Taiwan
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Taipei, 11217, Taiwan
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Taoyuan, 333, Taiwan
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Bangkok, 10700, Thailand
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Hat Yai, 90110, Thailand
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Bristol, BS2 8ED, United Kingdom
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Cambridge, CB2 0QQ, United Kingdom
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Preston, PR2 9HT, United Kingdom
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Sheffield, S10 2SJ, United Kingdom

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