Aloe vera concentrate put to the test against chronic bladder pain

NCT ID NCT04734106

Recruiting now Symptom relief Sponsor: Wake Forest University Health Sciences Source: ClinicalTrials.gov ↗

First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time

Summary

This study tests whether a super-concentrated, freeze-dried aloe vera capsule can safely reduce symptoms of interstitial cystitis, a chronic bladder condition causing pain and frequent urination. About 30 adults with frequent urination and moderate-to-severe pain will receive either the aloe vera supplement or a placebo for several weeks. Researchers will track side effects and changes in bladder symptoms using standard questionnaires.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: super-concentrated, freeze-dried aloe vera capsules
What this could lead to: If it works, this could offer a natural option for managing the pain and urinary urgency of interstitial cystitis.
What could go wrong: This is a very early, small trial, so results may not apply widely. Aloe vera supplements can cause digestive upset in some people.

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Conditions

The condition(s) this trial relates to.

interstitial cystitis Nocturia Urinary Incontinence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLADDER PAIN SYNDROME CHRONIC INTERSTITIAL CYSTITIS INTERSTITIAL CYSTITIS

Contacts and locations

Locations

Wake Forest Baptist Hospital
RECRUITING

Winston-Salem, North Carolina, 27157, United States

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