Can a nerve pain drug boost bladder pain relief?

NCT ID NCT07752134

First seen Aug 07, 2026 ยท Last updated Aug 07, 2026

Summary

This trial is testing whether adding the nerve pain medication pregabalin to a structured educational and behavioral program can better ease the symptoms of bladder pain syndrome (also called interstitial cystitis) than the program alone. Adults with this condition will be randomly assigned to receive either the program by itself or the program plus pregabalin, with doses adjusted over 12 weeks. Researchers will compare how many people in each group report meaningful improvement in their overall well-being, and will also track pain, urinary symptoms, sleep, and quality of life. The goal is to see if the combination offers a more effective way to manage this chronic, painful condition.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
pregabalin combined with an educational and behavioral management program
What this could lead to
If successful, this combination could offer a more effective non-surgical option for managing bladder pain syndrome, potentially improving pain, urinary symptoms, and quality of life.
What could go wrong
This is an early-phase trial, so results may not hold up in larger studies. Pregabalin can cause side effects like dizziness and drowsiness, and the added benefit over education alone is not yet proven.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

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