Urinary bladder disorder

This phase 3 trial tests whether a combination of enfortumab vedotin and pembrolizumab, given before and after bladder removal surgery, works better than standard chemotherapy for muscle-invasive bladder cancer. About 800 participants will be randomly assigned to one of the two t…

This phase 3 trial tested whether adding bevacizumab (Avastin) to standard chemotherapy (gemcitabine and cisplatin) helps people with advanced urinary tract cancer live longer. 506 patients with cancer that had spread or could not be removed by surgery took part. The study compar…

This phase 2 trial tested a combination of two drugs—TAR-200 (placed directly into the bladder) and cetrelimab (an immunotherapy given by IV)—in 163 people with muscle-invasive bladder cancer who were scheduled for bladder removal surgery and could not or would not take standard …

This trial compared two blood thinners—apixaban (a pill) and enoxaparin (a shot)—in 126 bladder cancer patients after bladder removal surgery. The goal was to see which one patients were more likely to take as prescribed, which they preferred, and what it cost them. Participants …

This pilot study tested whether adding the anti-inflammatory drug celecoxib (Celebrex) to standard chemotherapy before bladder cancer surgery is safe and affects tumor genes. 22 people with muscle-invasive bladder cancer took part. The goal was to see how the treatment changed ca…

This study evaluates the long-term safety and effectiveness of Advantage® strips, a type of surgical tape, for treating stress urinary incontinence in women. Researchers are reviewing the medical records of 500 women who received the strip between 2012 and 2015, with an average f…

This registry follows 180 women receiving an artificial urinary sphincter for stress incontinence caused by a weak sphincter. Researchers measure how many become dry (using no pads or just one light pad) and how long that dryness lasts over 5 years. Participants also report on se…

This early-phase trial tested two drugs—durvalumab and vicineum—in 15 people with high-grade non-muscle-invasive bladder cancer that had not responded to standard BCG treatment. The goal was to see if the combination is safe and can help the immune system fight the cancer. Partic…

This early-phase study tested a personalized cancer vaccine (RO7198457) in 273 patients with advanced solid tumors like melanoma, lung, and breast cancer. The vaccine was given alone or with an immunotherapy drug (atezolizumab) to see if it was safe and how the body responded. Th…

This study tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy before and after bladder removal surgery helps people with muscle-invasive bladder cancer live longer without the cancer coming back. About 900 participants took part. The goal was to s…

This study tested a new way to treat muscle-invasive bladder cancer by tailoring therapy based on each patient's tumor genetics. After initial chemotherapy, patients with a good response could avoid bladder removal and instead opt for active monitoring or less invasive treatments…

This study compared two types of surgery to remove the bladder in people with bladder cancer: one done with a robot and one done as open surgery. About 339 patients took part across multiple hospitals. The main goal was to see which approach let patients spend more days at home a…

This phase 1 trial tested a new treatment called urinary microbiota transplantation (UMT) for people with cystitis glandularis, a chronic bladder condition often linked to pelvic lipomatosis. The treatment involves placing processed donor urine bacteria into the bladder. After on…

This study compared two surgical techniques for removing early-stage bladder tumors: a new laser method (holmium laser en-bloc resection) and the standard approach (conventional transurethral resection). 100 adults with suspected non-muscle-invasive bladder cancer were randomly a…

This phase 2 trial tested a new cancer vaccine (IO102-IO103) combined with the immunotherapy drug pembrolizumab as a first treatment for people with advanced lung, head/neck, or bladder cancer that had spread. The study enrolled 63 participants to see if the combination is safe a…

This study tested an experimental drug called BMS-986016 (anti-LAG-3) alone or combined with nivolumab in people with advanced solid tumors that had spread or couldn't be removed by surgery. It included several cancer types like lung, stomach, liver, kidney, bladder, head and nec…

This study tested a closed-system bladder irrigation device designed to reduce urinary tract infections after endoscopic urologic surgery. 240 patients undergoing prostate or bladder tumor surgery were randomly assigned to use the new device or standard irrigation. The device all…

This early-phase trial tested an experimental drug called BAT8010 in 23 people with advanced or metastatic solid tumors who had no other standard treatment options. The main goals were to check safety, find the best dose, and see if the drug shows any sign of shrinking tumors. Pa…

This study tested a new treatment called VG161, a virus designed to attack cancer cells, in 20 people with a type of bladder cancer that didn't respond to standard therapy. The virus was given directly into the bladder through a tube. The goal was to see if it is safe and if it c…

This study tested a drug called sacituzumab govitecan given before bladder removal surgery in 44 people with muscle-invasive bladder cancer who could not take or refused standard cisplatin chemotherapy. The goal was to see if the drug could completely eliminate the tumor by the t…

This study tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemotherapy (gemcitabine and cisplatin) could shrink tumors more effectively before bladder cancer surgery. 39 people with muscle-invasive bladder cancer received the combination before …

This study looked at 100 women with stress urinary incontinence who had a surgery to place a sling under the urethra. The goal was to see how many were cured or improved after the operation. Doctors used cough tests and patient surveys to measure success.

This study tested a new drug called DF1001 in 270 adults with advanced solid tumors that have spread or cannot be removed. The drug works by helping the body's immune cells attack cancer cells. The trial first found the safest dose, then tested it alone or with other cancer drugs…

This study tested a vaginal suture knotting device (VACS-MINIFIKS) in 36 women with stress urinary incontinence. The goal was to see if the device could reduce urine leakage and improve quality of life over 24 months. Participants had pad tests and questionnaires to measure succe…

This phase 2 trial tested a combination of two chemotherapy drugs, cabazitaxel and cisplatin, given before surgery to remove the bladder in 28 patients with invasive bladder cancer. The goal was to see if the drugs could shrink the tumor enough to improve outcomes. The study also…

This study tested the safety of combining different doses of external radiation therapy with the chemotherapy drug gemcitabine in 19 bladder cancer patients. The goal was to find the highest safe dose of radiation that can be given alongside chemo. Participants had early-stage bl…

This study tested whether giving a short, intensive course of the chemotherapy drug Mitomycin C before surgery (chemoresection) could lower the chance of bladder cancer coming back, compared to the usual approach of surgery followed by regular chemotherapy instillations into the …

This early-stage study tested a combination of two drugs—CG0070 (a virus that targets cancer cells) and nivolumab (an immunotherapy that boosts the immune system)—in 21 people with muscle-invasive bladder cancer who were not eligible for standard chemotherapy. The goal was to see…

This phase 2 trial tested a daily pill called erdafitinib against standard chemotherapy for people with a high-risk bladder cancer that returned after BCG treatment. The study enrolled 107 participants whose tumors have specific FGFR gene changes. The goal was to see if erdafitin…

This study tested two or three drugs together in adults with advanced solid tumors (cancers that have spread). The main goal was to find the safest dose and see if the combination can shrink tumors. Participants took brigimadlin pills and received ezabenlimab infusions every 3 we…

This study tested whether hyperbaric oxygen therapy (HBOT) can help heal severe tissue damage caused by past radiation treatment. 39 adults who had radiotherapy and developed serious radiation injuries received HBOT sessions in a pressurized chamber while breathing pure oxygen. T…

This completed study tested a three-step treatment for muscle invasive bladder cancer: chemotherapy, then a minimally invasive surgery to remove the tumor, followed by radiation. The goal was to treat the cancer while keeping the bladder intact, which could improve quality of lif…

This pilot study tested a drug called BGJ398 in 4 people with a type of bladder cancer that stays in the bladder lining but keeps coming back after standard treatment. The drug targets tumors with a specific genetic change (FGFR3 mutation or fusion). The main goal was to see if t…

This early-phase study tested whether genetically modified T-cells (MAGE-A10ᶜ⁷⁹⁶T) are safe for people with advanced urothelial cancer, melanoma, or head and neck cancer. Ten participants received their own engineered immune cells after chemotherapy. The main goal was to check fo…

This study looked at whether a special care plan led by a geriatrician and a nurse could improve survival and quality of life for older adults (70+) with advanced cancer. 792 patients with breast, colorectal, lung, prostate, bladder, ovarian cancer, or lymphoma took part. The app…

This study tested two injections made from a woman's own blood (platelet-rich plasma and platelet-rich fibrin) to treat stress urinary incontinence—leaking urine when coughing, sneezing, or exercising. Forty women aged 30-75 who could not or did not want surgery received one of t…

This completed phase 2 trial tested a combination of cryoablation (freezing tumors with a needle) and immunotherapy drugs (pembrolizumab or avelumab) in 9 people with metastatic bladder cancer. The goal was to see if this approach could shrink tumors that were not frozen. The stu…

This study tested several immunotherapy-based drug combinations in 272 people with advanced bladder cancer that had worsened after platinum chemotherapy. The goal was to see which combinations were safest and most effective at shrinking tumors or slowing the disease. Participants…

This study looked at children aged 3 to 15 with overactive bladder caused by nerve problems. It compared two different doses of Botox injections into the bladder muscle to see if a lower dose works just as well as a higher dose. The goal was to improve bladder capacity and reduce…

This study compares two surgical methods for removing non-muscle invasive bladder tumors. The new method removes the tumor in one piece, while the standard method removes it in fragments. Researchers want to see if the one-piece approach leads to better tumor removal and fewer re…

This study tested two surgical methods for removing early-stage bladder tumors that haven't spread to muscle. One method removes the tumor in one piece (en bloc), while the standard method removes it in multiple pieces. Researchers wanted to see if the one-piece method gives bett…

This study tested a weekly, higher-dose radiation schedule (hypofractionated radiotherapy) for people with muscle-invasive bladder cancer who cannot have standard daily radiation or surgery. It included 65 participants and compared standard radiation planning with a newer 'adapti…

This early-phase trial tested a new drug called UGN-301 (zalifrelimab) given directly into the bladder for people with recurrent non-muscle invasive bladder cancer. The study included 51 participants and aimed to check safety and find the right dose, both alone and with other dru…

This study tested an artificial urinary sphincter implant in 145 men with stress urinary incontinence after prostate surgery. The device is designed to mimic natural bladder control by opening and closing the urethra. Researchers measured how many men had at least a 50% reduction…

This study tested a new drug called enfortumab vedotin against standard chemotherapy in 608 adults with advanced bladder or urinary tract cancer that had spread or come back after prior treatment. The goal was to see if the new drug helped people live longer and slowed cancer gro…

This study tested a combination of two drugs (toripalimab and gemcitabine) given before surgery to 50 people with muscle-invasive bladder cancer who cannot take the standard chemotherapy drug cisplatin. The goal was to see how many patients had their tumors shrink or disappear. T…

This study looked at 150 people who had surgery for early-stage bladder cancer. After surgery, they received one of three different fluids (distilled water, normal saline, or hypertonic saline) to wash the bladder. The goal was to see if any fluid was better at preventing the can…

This study tested a protein called GcMAF, which is made from vitamin D-binding protein and is thought to calm the immune system. Researchers gave it to 120 adults with chronic inflammatory conditions like rheumatoid arthritis or cystitis that didn't improve with standard treatmen…

This study tested a vaccine called Bilhvax, given alongside a standard treatment (praziquantel), to see if it could delay the return of schistosomiasis (a parasitic infection) in children aged 6 to 9 in Senegal. The vaccine was given as three shots plus a booster one year later. …

This study tested a small implantable device that stimulates the tibial nerve to treat overactive bladder. 188 adults with urge incontinence who had not improved with other treatments received the implant. The main goal was to see if at least half of participants had a 50% or gre…

This phase II trial tested the immunotherapy drug pembrolizumab (Keytruda) alone or with another agent in 296 people with high-risk non-muscle-invasive bladder cancer that did not respond to standard BCG therapy. Participants received the drug intravenously every three weeks. The…

This study tested a device that uses mild electrical pulses to calm the nerves controlling the bladder. It was for people with sudden, strong urges to urinate that cause leaks, who didn't get help from other treatments. The goal was to see if the device safely reduces leaks by at…

This study tested enfortumab vedotin, a drug that delivers chemotherapy directly to cancer cells, in 40 Chinese patients with advanced bladder cancer that had worsened after standard treatments. The main goal was to see how many patients' tumors shrank. The trial also looked at h…

This study tested two different chemotherapy drug combinations in 500 people with advanced bladder cancer that had not spread to other organs. The goal was to see which treatment worked better at stopping the cancer from coming back after surgery. Participants received either gem…

This phase 2 trial tested pemigatinib, a daily pill that blocks certain growth signals, in 30 people with recurrent low- or intermediate-risk non-muscle invasive bladder cancer. Participants took the drug for 4-6 weeks before their standard surgery to remove bladder tumors. The m…

This completed study looked at how well the Axonics sacral neuromodulation system works for people with bladder or bowel control problems. 272 participants were tracked to see if their symptoms improved and if the device was safe. The device uses mild electrical pulses to calm ov…

This pilot study tested whether giving pembrolizumab (an immunotherapy) along with standard chemotherapy before surgery could help people with rare types of muscle-invasive bladder cancer. 17 participants received the combination, and researchers measured how many had no cancer l…

This study tested a temporary urethral stent in 9 men with spinal cord injuries who had trouble emptying their bladders. The stent is placed under local anesthesia to keep the urinary channel open. The goal was to see if patients felt their voiding improved, and to check for prob…

This study tested an experimental drug called ESG401 in 156 people with advanced solid tumors (including breast, lung, and colorectal cancers) who had no other treatment options. The goal was to check the drug's safety, find the right dose, and see if it could shrink tumors. The …

This study tested a special chair that uses high-intensity electromagnetic waves to make pelvic floor muscles contract very strongly, like doing thousands of Kegel exercises in one session. 36 women with stress or urge urinary incontinence received either the full treatment or a …

This pilot study tested whether a new radioactive tracer called 18F-fluciclovine, used with a PET/CT scan, can better determine the extent of muscle invasive bladder cancer before surgery. Sixteen participants with bladder cancer received the tracer and scan before their planned …

This study tested whether analyzing urine with a special light technique (spectroscopy) can accurately detect bladder cancer. Researchers collected urine samples from 899 people undergoing cystoscopy. The goal was to see if the light patterns could tell apart those with cancer fr…

This study tested how well a special MRI scan (called multiparametric MRI) can tell if bladder cancer has grown into the muscle layer of the bladder. Researchers used a scoring system called VI-RADS to interpret the scans. The study included 60 people with bladder masses who were…

This study looked at whether a new urine test called VISIOCYT can better detect bladder tumors than standard methods. Over 700 patients undergoing cystoscopy (a scope procedure) provided urine samples for both standard and VISIOCYT analysis. The goal was to see how accurate the n…

This study tested whether a simple urine test (Xpert Bladder Cancer Detection Test) can accurately detect bladder cancer in people undergoing cystoscopy. Researchers enrolled 127 adults in Greenland, where access to urology services is limited. The goal was to see if the urine te…

This study tested whether a special type of PET/MR scan (using radioactive water) can accurately tell if bladder cancer has been completely eliminated by chemotherapy. 13 patients with muscle-invasive bladder cancer were scanned before and after chemotherapy, and the results were…

This study looked at whether an automated measuring device can improve the accuracy of bladder diaries in women with lower urinary tract symptoms. 187 women recorded their urine volume using both a traditional paper diary and an electronic device. The goal was to see if the devic…

This study asked 107 people with a history of non-muscle invasive bladder cancer whether they preferred a non-invasive urine test (CxBladder Monitor) or the standard cystoscopy (a thin tube inserted into the bladder) for routine cancer surveillance. Participants tried both method…

This early-phase study tested a new imaging agent called 89Zr-girentuximab in 6 people with non-muscle-invasive bladder cancer. The goal was to see if it could safely and clearly show tumors on PET/CT scans. Researchers looked for uptake spots in the bladder and checked for side …

This study tested a new wireless device called the Glean Urodynamics System (GUS) that measures bladder pressure without a catheter. Thirty-eight adults with urinary symptoms used the device after a standard test. The goal was to see if the device is safe, easy to use, and more c…

This study tested whether advanced MRI scans can better determine how deeply bladder cancer has grown into the bladder wall. Accurate staging is crucial because it decides whether a patient needs just surgery or also chemotherapy and bladder removal. The study enrolled 186 people…

This completed study in Pemba, Tanzania, compared several diagnostic tests for Schistosoma haematobium, a parasitic worm that causes a debilitating disease. Researchers tested 801 schoolchildren using methods like urine filtration, AI microscopy, and molecular tests. The goal was…

This study tested whether adding tactile (touch) feedback to pelvic floor muscle training helps prevent stress urinary incontinence in pregnant women. 141 women in their third trimester were assigned to routine education, standard pelvic floor exercises, or exercises with hands-o…

This study investigates whether acupuncture can relieve symptoms and improve quality of life in women diagnosed with treatment-resistant interstitial cystitis/bladder pain syndrome. Participants receive eight sessions of acupuncture over four weeks at specific points on the body.…

This study compares two store-bought devices for stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). About 80 women will try both devices over 20 days and report which they prefer. The goal is to see if a web-based study is practical and what facto…

This study tested whether pelvic floor muscle training, mirabegron, or trospium chloride is better for treating urgency urinary incontinence in women aged 60 and older who are also at high risk of falling. 48 women were randomly assigned to one of three groups and followed for si…

This study tests whether a daily cranberry extract pill can change the bacteria in the bladder to reduce sudden urges and frequent bathroom trips in women who do not have leakage. Researchers will compare bacteria samples and symptom scores before and after 12 weeks of treatment.…

This study tested a prescription smartphone app called RiSolve for women with overactive bladder (OAB). The app provides an 8-week program of bladder training, pelvic floor exercises, and digital cognitive behavioral therapy. Researchers enrolled 46 women in Ireland to see if the…

This study tested whether a shared decision-making tool could help women with uncomplicated cystitis (bladder infection) and their doctors decide together about antibiotic use. 169 women aged 18-65 participated. The goal was to see if the tool reduced antibiotic use without harmi…

This completed early-phase trial tested whether low-intensity shockwave therapy (Li-ESWT) can ease symptoms of radiation cystitis, a painful bladder condition from pelvic radiation. Twenty-five adults who had radiation at least six months prior were enrolled. The study compared s…

This study looked at whether using lidocaine (a numbing drug) instead of saline during sling surgery helps women avoid urinary retention. About 150 women with stress incontinence took part. The goal was to see if fewer women need a catheter after surgery.

This study looked at two methods for removing kidney stones: laser dusting (breaking stones into tiny pieces that pass naturally) and basket extraction (using a small wire basket to remove fragments). Researchers compared how well each method cleared stones, how much pain patient…

This study tested a smartphone app designed to help women with urinary incontinence reduce leakage episodes and improve quality of life. About 194 women used the app or received standard care for 12 weeks. The goal was to see if the app could cut incontinence episodes in half.

This study tested a modified Single-J ureteric stent designed to cause less discomfort than the standard Double-J stent after kidney stone surgery. 28 adults who already had a stent placed before surgery received the modified stent during their procedure. Researchers compared sym…

This early-phase trial tested whether a nutritional supplement called Impact Advanced Recovery® could help men recover better after bladder cancer surgery. Thirty men took the drink before and after their operation. The goal was to see if it reduced surgical complications, infect…

This study looked at whether two drugs, mirabegron and montelukast, are safe and helpful for people with liver cirrhosis who also have overactive bladder and asthma. 78 participants took part over 3 months. Researchers tracked bladder symptoms, breathing issues, and side effects …

This study looked at 184 women with stress urinary incontinence who had a single-incision sling surgery. Researchers compared two sling insertion angles—one acute and one standard—to see which led to better cure rates and quality of life at 6 months. The goal is to find the best …

This study tested whether a non-invasive magnetic brain stimulation technique (rTMS) can help adults with overactive bladder. Researchers measured changes in brain activity and bladder symptoms in 14 participants. The goal was to see if targeting specific brain regions could impr…

This study tested two ways to numb the obturator nerve during bladder tumor surgery to prevent sudden leg muscle spasms that can cause complications. Sixty patients aged 50-80 were randomly assigned to receive either a single-injection or a two-injection nerve block. The goal was…

This study tested a program to help bladder cancer patients and their caregivers prepare for and recover from bladder removal surgery. A nurse or health professional provided pre-surgery education and stoma care training, and patients got access to a recovery website with videos …

This study tested two treatments for vestibulodynia, a chronic pain condition affecting the vulvar area. 209 women received either a lidocaine/estradiol cream, the antidepressant nortriptyline, both, or a placebo. The goal was to see which approach best reduces pain and improves …

This study tested whether giving low-dose nitrous oxide (laughing gas) during a urodynamic study (a test for urinary symptoms) changes key bladder measurements like capacity and pressure. 19 adults scheduled for the test took part. If the measurements stay the same, nitrous oxide…

This study tested whether an extended-release version of the diuretic torsemide works better than the standard immediate-release form for reducing overactive bladder symptoms in people with chronic heart failure. Twenty-four participants took each version for four weeks, tracking…

This early-stage study tested a drug called V117957 in 47 women with interstitial cystitis, a condition causing bladder pain and discomfort. Participants took either the drug or a placebo at bedtime to see if it safely reduced pain. The trial is now complete, and results will hel…

This study looked at 93 adults having bladder tumor surgery under spinal anesthesia. It compared two intravenous drugs—magnesium sulfate and dexmedetomidine—to see which better controlled pain after surgery. Magnesium sulfate led to lower pain scores, delayed the need for extra p…

This completed study compared two ways to control pain after radical cystectomy (bladder removal) surgery: thoracic epidural analgesia (TEA) and ultrasound-guided erector spinae plane (ESP) block. Twenty patients aged 40-70 were enrolled. The goal was to see which method provides…

This study tested whether giving Botox in one injection site works as well as ten sites for women with overactive bladder or urge incontinence. 116 women were randomly assigned to receive 100 units of Botox in either one or ten spots in the bladder. Researchers measured symptom s…

This study tested three exercise programs for stress urinary incontinence in 78 women: Pilates alone, Pilates with voluntary pelvic floor contractions, and isolated pelvic floor training. Participants did 12 sessions over 6 weeks. The goal was to see which approach best reduces l…

This study looked at 96 men who needed a temporary tube (stent) in their ureter after kidney stone surgery. Half got a standard stent, the other half got a new anti-reflux stent. Researchers checked sexual function, mood, and hormone levels over 8 weeks to see if the anti-reflux …

This study tested whether applying gentle radiofrequency energy (like deep heat) to the bladder area can reduce symptoms of overactive bladder and sudden urine leakage. 95 women were randomly assigned to receive either real radiofrequency or a sham (placebo) treatment. Researcher…

This completed Phase 3 trial tested the antibiotic gepotidacin in 97 adolescent and adult women with uncomplicated urinary tract infections (UTIs). The goal was to see if symptoms like pain and urgency improved within 24 hours. Researchers measured symptom scores and safety. The …

This study looked at whether a low-dose vaginal estrogen tablet could improve overactive bladder symptoms in menopausal women by changing the bacteria in their urine. Thirty women used the tablet daily for two weeks, then twice a week for 12 weeks. Researchers measured changes in…

This study tested whether radiofrequency therapy, pelvic floor exercises, or both can help women with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). 239 women participated and were followed for one year. The goal was to see which treatment bes…

This study tested whether women with overactive bladder (OAB) could easily use the FemPulse System, a non-implanted vaginal electrical stimulation device. Eleven women with OAB symptoms used the device and completed a survey about its usability. The goal was simply to see if the …

This completed trial tested a new non-implanted device that uses mild electrical stimulation to help control overactive bladder in women. 21 women with the condition used the FemPulse System, and researchers tracked side effects, urinary frequency, urgency, and quality of life. T…

This study tested whether a program of reflex postural control exercises on a foam surface can reduce stress urinary incontinence in women. 88 women participated, doing supervised exercises and a home program. The main goal was to see if urine leakage decreased after the program.

This study tested whether women with overactive bladder (OAB) can easily use the FemPulse system at home. Five women with OAB for over 6 months participated. The main goal was to see if they were satisfied with using the device as instructed.

This study looked at whether a shorter (3-week) or longer (6-week) period of activity restriction after midurethral sling surgery leads to better recovery and satisfaction. 206 women who had the surgery were followed. The goal was to find the best balance between healing and gett…

This study looked at whether adding a special type of electrical stimulation to standard pelvic floor exercises can help women with very weak pelvic floor muscles and stress urinary incontinence. Fifty women who had given birth 6-18 months earlier and had very weak muscles partic…

This study looked at 100 adults with large upper ureteric stones (over 10 mm) to compare two surgical techniques: one going down from the kidney (antegrade) and one going up from the bladder (retrograde). The goal was to see which method removes stones more completely and safely,…

This study tested two ways of scheduling maintenance therapy for overactive bladder using percutaneous tibial nerve stimulation (PTNS). 37 women who had already completed 12 weekly PTNS sessions were assigned to either monthly treatments or sessions only when they felt they neede…

This study looked at whether a home-based nerve stimulation treatment (TTNS) works as well as a clinic-based version (PTNS) for overactive bladder. About 70 patients from a county hospital tried one of the two treatments and reported their symptoms and satisfaction. The goal was …

This study tested whether amitriptyline, a drug already used for depression and some chronic pain conditions, can relieve symptoms of painful bladder syndrome (PBS) in people newly diagnosed with the condition. PBS causes frequent urination and increasing pain as the bladder fill…

This study tested a gel called Cystistat (sodium hyaluronate) placed directly into the bladder to treat women with interstitial cystitis, a condition causing long-term bladder pain. Researchers tracked 74 women to see if the gel improved their symptoms and was safe. The goal was …

This study looked at whether adding tadalafil (a drug for erectile dysfunction and enlarged prostate) to solifenacin (a standard overactive bladder drug) works better than solifenacin alone for women with overactive bladder. 80 women aged 18 to 60 with symptoms for over 6 months …

This study tested two non-invasive treatments—pulsed electromagnetic field therapy and laser acupuncture—for stress urinary incontinence in 60 women. Both were added to pelvic floor muscle training. The goal was to see which better strengthens pelvic muscles and reduces accidenta…

This study tested whether ketorolac, a non-steroidal anti-inflammatory drug (NSAID), works as well as the opioid oxycodone for pain after kidney stone removal. 81 adults who had ureteroscopy and received a ureteral stent took part. For five days after surgery, they recorded their…

This study tested a fractional carbon dioxide laser treatment for women with vaginal and urinary symptoms like dryness, burning, pain during sex, and incontinence. One hundred women received three laser sessions about six weeks apart. The main goal was to see if symptoms improved…

This study looked at how well a gel called Bulkamid works for stress urinary incontinence in women. The gel is injected around the urethra to help the bladder control urine flow. Researchers tracked symptom improvement in 70 women who received the injection. The goal was to see h…

This study tested whether mild electrical pulses to nerves in the leg and lower back can help women with multiple sclerosis who have overactive bladder symptoms like sudden urges and leaks. Forty-two women received the stimulation over several sessions. The goal was to see if it …

This study tested whether high-dose vitamin D plus behavioral therapy can help children with dry overactive bladder (OAB) urinate less often. 180 children received either standard drugs or vitamin D drops for a short time. The goal was to see if vitamin D works better than usual …

This study tested whether stimulating nerves on one side or both sides of the body works better for people with overactive bladder that hasn't improved with standard treatments. 55 adults were randomly assigned to receive either unilateral or bilateral nerve stimulation. The goal…

This study looked at 224 adults with kidney or ureter stones who needed a stent after surgery. Half got a silicone stent, half got a standard plastic stent. The goal was to see which type caused less pain and interference with daily life in the days and weeks after surgery.

This study tested a health cloud platform accessed via smartphone to help patients who have a urostomy after bladder cancer surgery. The platform allowed patients to check their medical info and communicate with nurses. Researchers measured whether this improved patients' ability…

This study tested a small device called eCoin that is implanted under the skin near the ankle to stimulate a nerve that controls the bladder. The goal was to see if it could reduce urgent, frequent urination and accidental leaks in people with overactive bladder. 133 adults who h…

This study tested a connected biofeedback probe called EMY, which women use at home with a mobile app to train their pelvic floor muscles. The goal was to see if it improves quality of life for women with stress urinary incontinence—leaking urine when coughing, sneezing, or exerc…

This study compared two common surgeries for removing large kidney stones stuck in the upper ureter: ureteroscopic lithotripsy (URS) and laparoscopic ureterolithotomy (LU). Fifty-six adults with a single stone between 10-20 mm were randomly assigned to one procedure. Researchers …

This completed trial tested whether a special laser (Fotona Smooth Erbium YAG) can help women with stress urinary incontinence who haven't improved with exercises. Thirty women were randomly assigned to get either real laser treatments or a fake (sham) procedure, and neither they…

This study tested a small implantable device that stimulates a nerve in the leg to help control overactive bladder symptoms. 282 women with frequent sudden urine leaks received the implant. The main goal was to see if at least half of them had a 50% or greater reduction in leaks …

This study tested whether a magnetic stimulation chair can help women with sudden, strong urges to urinate that lead to leaks. 70 women received either real or sham magnetic stimulation while sitting fully clothed. Researchers measured changes in bladder diary entries, questionna…

This completed phase 3 trial tested whether taking psyllium husk fiber capsules during pelvic radiation therapy could reduce gut inflammation and urgency symptoms. 354 adults with pelvic cancers (like rectal, prostate, or gynecological) took either fiber or placebo capsules daily…

This study looked at whether three proteins (E-cadherin, β-catenin, and SOX4) can help predict if non-muscle invasive bladder cancer will return or get worse after surgery. Researchers examined tissue samples from 30 patients who had bladder tumor removal. The goal was to see if …

This study analyzes data from 748 patients who had their bladder removed due to bladder cancer. The goal is to find factors that can predict whether cancer has spread to the ureter, the tube that carries urine from the kidney to the bladder. By identifying these factors, doctors …

This study tested whether doing a second surgery soon after the first helps manage high-risk non-muscle invasive bladder cancer. 70 patients who had an initial tumor removal got an early second look procedure. The goal was to see if any cancer remained and what factors affected t…

This study developed an AI model to predict how well bladder cancer responds to treatment before surgery. Researchers used data from 469 patients, including medical images and genetic information, to train the AI. The goal is to help doctors choose the best treatment plan for eac…

This study tested a new method to measure bladder fullness using heart signals. Researchers placed sticky patches (electrodes) on the body to record the heart's electrical activity during a standard bladder test. The goal was to develop a computer algorithm that could estimate bl…

This study tested whether short, focused lessons (microlearning) can help patients remember important health information and feel more confident after same-day surgery. Researchers enrolled 5 adults scheduled for specific gynecological procedures. Participants completed surveys b…

This study compared penile length in 200 adult men undergoing cystoscopy under spinal anesthesia versus general anesthesia. Researchers measured length and asked surgeons to rate satisfaction with access. The goal was to see if anesthesia choice affects penile size during the pro…

This completed study looked at how the brain controls the bladder in older women with urgency urinary incontinence. Researchers used MRI scans to compare brain activity during bladder filling and emptying in 207 women, both young and old, with and without incontinence. The goal w…

This study tested whether an AI tool can help health providers write medical summaries that are easier for patients to understand. 120 providers were split into two groups: one used the AI tool, the other did not. The goal was to see if AI could improve readability and save time,…

This completed study involved 93 adults with stage 4 incurable bladder cancer. Participants completed surveys and focus groups to identify their supportive care and educational needs. The goal was to design a screening tool to help healthcare teams better address these needs in t…

This study tested a new online tool called the Personal Patient Profile for Bladder Cancer (P3BC) in 24 patients who were facing bladder removal surgery. The tool provides personalized information, videos, and summaries to help patients talk with their doctors and prepare for rec…

This study looked at how the brain works in women aged 60 and older who have sudden, strong urges to urinate (urgency urinary incontinence). Participants took a medication called trospium or a placebo, and had brain scans (MRI) to see if changes in brain activity relate to fewer …

This completed study analyzed health records from over 2 million people with type 2 diabetes to see if those taking dapagliflozin had a different risk of breast or bladder cancer compared to those on other diabetes medications. Researchers tracked cancer diagnoses for up to 12 ye…

This completed study tested whether a new biomarker called 'mass response' can predict how well a cancer therapy will work. Researchers collected tumor cells from 72 patients with various cancers through fluid drainage or biopsies. The goal was to see if this biomarker could guid…

This study looked at 130 people treated for ureteral stones using two different sizes of ureteroscopes. Researchers measured how well each scope worked and how much stress the surgeon felt before and after the procedure. The goal is to find out if using a smaller or larger scope …

This study looked at how immune checkpoint inhibitors, a type of cancer drug, might affect blood vessels and increase heart risks. Researchers measured blood vessel function and checked for related markers in 39 cancer patients before and after starting treatment. The goal was to…

This study looks at whether the drug T-DXd works better than standard treatments for people with several types of HER2-positive solid tumors. Researchers will compare data from previous T-DXd trials with real-world medical records of patients who received standard care. The goal …

This study looked at whether special ultrasound measurements of the urethra can predict how severe a woman's stress urinary incontinence (leaking urine when coughing, sneezing, or exercising) will be. Researchers measured the length and angle of the urethra in 50 adult women. The…

This study looked at 27 postmenopausal women with frequent urinary tract infections (UTIs) to understand why vaginal estrogen therapy prevents UTIs in only about half of them. Researchers examined changes in bacteria in the vagina and bladder, as well as immune responses, before …

This study looked at 51 women with long-term hip pain to see if their pelvic floor muscle function was related to their pain and anxiety. Researchers used ultrasound and questionnaires to measure muscle movement, strength, and incontinence. The goal was to better understand these…

This study looked at 150 women with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising) who completed a three-month pelvic floor muscle training program. Researchers measured the anogenital distance (the space between the anus and genitals) and geni…

This study looked at 61 women with overactive bladder whose symptoms didn't improve with one medication. Researchers gave them a combination of two drugs and tracked which factors made treatment more likely to fail. The goal was to better understand who might need different treat…

This study looked at 80 women with stress urinary incontinence (leaking urine when coughing or sneezing) to compare three common surgeries: TOT, TVT, and Burch colposuspension. Researchers used ultrasound to measure changes in the bladder and urethra before and 3 months after sur…

This completed trial compared two surgical procedures for removing kidney stones: standard PCNL and mini-PCNL. The study enrolled 18 adults with stones 10-20mm and measured blood loss, complications, and recovery time. The goal was to see if the smaller incision approach offers a…

This study looked at 130 men aged 50+ with enlarged prostate (BPH) causing urinary symptoms. Researchers used an ultrasound to measure how far the prostate bulges into the bladder, then tracked symptom changes over 6 months of standard medication. The goal was to see if this simp…

This study looked at how bladder cancer surgery (cystectomy) affects patients' sexual quality of life over time. Researchers gave 50 participants questionnaires before and 8 months after surgery to track changes. The goal is to better understand long-term effects that are often o…

This study compared two surgical methods for removing medium-sized bladder tumors (2-6 cm) in 50 patients. One method removes the tumor in one piece (en-bloc), while the other removes it in fragments (conventional). The goal was to see which method provides better tissue samples …

This study looked at how different diets affect the bladder in 13 healthy adults. Participants followed a special diet for 12 weeks, then switched to an opposite diet for another 12 weeks. Researchers checked urine and bladder cells after each diet to see if food can change bladd…

This study looked at people with advanced solid tumors (like lung, bladder, or melanoma) who had been on immunotherapy for one year and whose disease was stable. Half stopped treatment and half continued. The goal was to see if stopping early affected how long until the cancer pr…

This study tested whether using at-home monitoring devices (like a wristband pedometer, scale, and blood pressure cuff) can help improve care for cancer patients after they leave the hospital following surgery. 22 patients with various cancers participated. The goal was to see if…

This study looked at whether measuring bits of tumor DNA in blood and urine (called ctDNA) is possible in people with muscle-invasive bladder cancer receiving a combination of surgery, radiation, and chemotherapy. The goal was to see if this approach could help monitor how well t…

This study looked at CT scans from 316 bladder cancer patients to see if a computer model could predict whether the cancer would come back after surgery. The goal was to find patterns in the scans that might help doctors identify high-risk patients earlier. This is a research stu…

This study tested whether using Fitbits and daily smartphone surveys after bladder cancer surgery can help doctors catch problems early and reduce hospital readmissions. 38 patients participated, with half receiving the remote monitoring program. The goal was to see if this appro…

This study looked at whether giving women intravenous (IV) fluids before tension-free vaginal tape (TVT) surgery for stress urinary incontinence helps them urinate sooner after the operation. 43 women took part, with some getting IV fluids and others not. The main goal was to see…

This study followed 30 men aged 45-70 who had their prostate removed due to cancer. Researchers measured urine leakage by weighing pads over 24 hours and during a 1-hour activity test. The goal was to better understand how long and how severe incontinence lasts after surgery.

This study tested a new system (PA-100 AST) to help doctors quickly choose the right antibiotic for women with urinary tract infections (UTIs). About 199 non-pregnant women with UTI symptoms provided urine samples, which were tested with the new system. The goal was to see if usi…

This study tested a web-based app called STOMA Care to see if it is practical and helpful for bladder or colorectal cancer patients getting ostomy surgery and their family caregivers. Researchers measured how well the app worked by tracking recruitment, retention, and changes in …

This study looked at whether FDG-PET CT scans can more accurately stage muscle invasive bladder cancer compared to standard CT scans. Researchers reviewed records of 130 patients who had PET CT scans at diagnosis. The goal was to see if PET CT better detects cancer spread to lymp…