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New drug targets Hard-to-Treat cancers in early trial

NCT ID NCT04143711

Completed Disease control Sponsor: Dragonfly Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new drug called DF1001 in 270 adults with advanced solid tumors that have spread or cannot be removed. The drug works by helping the body's immune cells attack cancer cells. The trial first found the safest dose, then tested it alone or with other cancer drugs in people with certain breast or lung cancers. The main goals were to check safety and see if tumors shrink.

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Conditions

The condition(s) this trial relates to.

bladder transitional cell carcinoma breast neoplasm HER2 positive breast carcinoma hormone receptor-positive breast cancer neoplasm non-small cell lung carcinoma urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOLID TUMOR, ADULT

Contacts and locations

Locations

  • Ajou University Hospital

    Gyeonggi-do, South Korea

  • Amsterdam University Medical Center

    Amsterdam, 1081 HV, Netherlands

  • Asan Medical Center

    Seoul, South Korea

  • CHA Bundang Medical Center, CHA University

    Gyeonggi-do, South Korea

  • Centre Hospitalier de l'Ardenne

    Arlon, 6700, Belgium

  • Centre Leon Berard

    Lyon, 69008, France

  • Centre Oscar Lambret

    Lille, 59020, France

  • Domaine Universitaire du Sart Tilman; CHU de Liege

    Liège, 4000, Belgium

  • Erasmus University Medical Center

    Rotterdam, 3015 ZH, Netherlands

  • Grand Hopital de Charleroi

    Charleroi, 6000, Belgium

  • Groupe Hospitalier Saint Andre

    Bordeaux, 33000, France

  • Herlev og Gentofte Hospital

    Herlev, 2730, Denmark

  • ICO - Site Rene Gauducheau

    Saint-Herblain, 44805, France

  • Icahn School of Medicine: Tisch Cancer Institute at Mount Sinai Medical Center

    New York, New York, 10023, United States

  • Inje University Haeundae Paik Hospital

    Busan, South Korea

  • Institut Claudius Regaud

    Toulouse, 31059, France

  • Institut Curie

    Paris, Paris, 75005, France

  • Institut Paoli Calmettes

    Marseille, 13009, France

  • Institut Regional du Cancer de Montepelier

    Montpellier, France

  • Korea University Guro Hospital

    Seoul, South Korea

  • Louisiana State University

    New Orleans, Louisiana, 70112, United States

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Maasticht University Medical Center

    Maastricht, 6229 HX, Netherlands

  • Montefiore Einstein Center for Cancer Care

    The Bronx, New York, 10461, United States

  • Multicare Health System Tacoma General Hospital

    Tacoma, Washington, 98405, United States

  • National Cancer Center

    Goyang-si, South Korea

  • Radboud University Nijmegen

    Nijmegen, 6525 EZ, Netherlands

  • Rhode Island Hospital

    Providence, Rhode Island, 02903, United States

  • Rigshospitalet

    Copenhagen, Capital Region, 2100, Denmark

  • Seoul National University Bundang Hospital

    Seongnam, South Korea

  • Seoul National University Hospital

    Seoul, South Korea

  • Severance Hospital

    Seoul, South Korea

  • Sharp Healthcare

    San Diego, California, 92123, United States

  • Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    Baltimore, Maryland, 21287, United States

  • The Ohio State University

    Columbus, Ohio, 43210, United States

  • UMC Utrecht

    Utrecht, 3508 GA, Netherlands

  • Universitair Medisch Centrum Groningen

    Groningen, 9713 GZ, Netherlands

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • University of California Irvine Medical Center

    Irvine, California, 92868, United States

  • University of California San Francisco

    San Francisco, California, 94143, United States

  • University of Kansas Medical Center Research Institute, Inc.

    Westwood, Kansas, 66205, United States

  • University of Southern California

    Los Angeles, California, 90033, United States

  • University of Wisconsin

    Madison, Wisconsin, 53715, United States

  • Vanderbilt-Ingram Cancer Center

    Nashville, Tennessee, 37232, United States

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