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New combo therapy shows promise for Hard-to-Treat cancers

NCT ID NCT03964233

Completed Disease control Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two or three drugs together in adults with advanced solid tumors (cancers that have spread). The main goal was to find the safest dose and see if the combination can shrink tumors. Participants took brigimadlin pills and received ezabenlimab infusions every 3 weeks for up to 2 years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bile duct cancer gastric cancer lung cancer neoplasm soft tissue sarcoma urinary bladder carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEOPLASMS

Contacts and locations

Locations

  • CTR Leon Berard

    Lyon, 69373, France

  • Central Hospital of Northern Pest - Military Hospital

    Budapest, 1062, Hungary

  • Hospital Clínico San Carlos

    Madrid, 28040, Spain

  • Hospital Universitari Vall D Hebron

    Barcelona, 08035, Spain

  • INS Bergonie

    Bordeaux, 33000, France

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Linear Clinical Research

    Nedlands, Western Australia, 6009, Australia

  • Memorial Sloan-Kettering Cancer Center

    New York, New York, 10065, United States

  • NEXT Oncology-Irving-69444

    Irving, Texas, 75039, United States

  • NEXT Oncology-San Antonio-65273

    San Antonio, Texas, 78229, United States

  • NEXT Virginia

    Fairfax, Virginia, 22031, United States

  • National Cancer Center Hospital

    Tokyo, Chuo-ku, 104-0045, Japan

  • National Cancer Centre Singapore

    Singapore, 168583, Singapore

  • Sarcoma Oncology Center

    Santa Monica, California, 90403, United States

  • The Royal Marsden Hospital, Chelsea

    London, SW3 6JJ, United Kingdom

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • UZ Leuven

    Leuven, 3000, Belgium

  • Universitair Medisch Centrum Groningen

    Groningen, 9713 GZ, Netherlands

  • University Cancer and Blood Center

    Athens, Georgia, 30607, United States

  • Universitätsklinikum Frankfurt

    Frankfurt, 60590, Germany

  • Universitätsklinikum Ulm

    Ulm, 89081, Germany

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • Yale Cancer Center

    New Haven, Connecticut, 06511, United States

More trials for these conditions

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