Female stress incontinence

This study tests a special scaffold placed during prostate removal surgery to help men regain bladder control. About 266 men will be randomly assigned to get the scaffold or standard care. The goal is to see if the scaffold reduces urine leakage and improves quality of life over …

This trial tests a device called Adjustable Continence Therapy (ACT) for women with stress urinary incontinence caused by a weak urethral sphincter. The implant has two balloons placed near the bladder neck that can be adjusted after surgery to improve control. The study will enr…

This study compares two procedures for stress urinary incontinence (leaking urine with cough, sneeze, or exercise) in 358 women. One group gets a bulking agent injection to thicken the urethra lining; the other gets a small mesh sling to support the urethra. The goal is to see wh…

This study follows about 195 women for up to 10 years after they receive a mesh sling (GYNECARE TVT ABBREVO) to treat stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). The main goal is to see how many women are still dry after 5-10 years. Partici…

This study tests a small, implanted device that stimulates the pudendal nerve to help control bladder function in women with mixed urinary incontinence (both stress and urge leaks). The device is personalized and adapts to each person's needs. Researchers will check if the proced…

This study is testing a new device called UrOActive®, an artificial urinary sphincter, in 140 men with stress urinary incontinence (leakage when coughing, sneezing, or moving). The device is implanted to help control urine flow. The main goal is to see if it reduces leakage by at…

This study compares two surgical procedures for stress urinary incontinence in women aged 60 and older: a synthetic mesh sling (TVT) and a sling made from the patient's own tissue (autologous fascia). Researchers will track new pelvic pain at 6 months and cure rates at 5 years, a…

This study tests whether giving patients a special nutritional drink (immunonutrition) before bladder removal surgery can reduce complications like infections. About 232 adults having open cystectomy for various bladder conditions will be randomly assigned to receive the drink or…

This study compares two medical sling devices used to treat stress urinary incontinence in women. About 300 women will receive either a single-incision sling or a standard transobturator sling. Researchers will check how well each device stops urine leakage during a cough test an…

This study looks at how well a surgical sling (a small mesh tape) works for women with stress urinary incontinence—leaking urine when coughing, sneezing, or exercising. Researchers will measure bladder function before and after surgery in 200 women. The goal is to see if the slin…

This study looks at whether adding a human amniotic membrane graft to standard mesh surgery can lower the risk of mesh exposure, a common complication. About 330 women with pelvic organ prolapse or stress urinary incontinence will take part. The goal is to see if the membrane hel…

This study tests a medical device (a perineal probe connected to a mobile app) for women with stress urinary incontinence. Participants use the device at home for 15 minutes, three times a week, plus two sessions with a physiotherapist. The goal is to see if this approach works a…

This study tests whether a once-daily pill called orforglipron can reduce stress urinary incontinence (leaking urine during movement) in women with obesity or overweight. About 1000 adult women will receive either the drug or a placebo for about 58 weeks. The main goal is to see …

This study tests whether adding hip abductor exercises to standard pelvic floor training can reduce urine leaks in women with stress urinary incontinence. About 78 women will be split into two groups: one does only pelvic floor exercises, the other adds hip exercises at home. The…

This study compares two types of core exercises—hypopressive training and transversus abdominis focused training—to see which better reduces urinary incontinence and improves pelvic floor function and quality of life in women after childbirth. Sixty women who had a normal vaginal…

This study compares two types of exercises—hypopressive exercises and the Paula method—to see which better helps postpartum women with urinary incontinence. Sixty women who had a vaginal delivery and leak urine at least once a week will do one of the two exercises twice a week fo…

This study compares two procedures—a sling or a bulkamide injection—to treat stress urinary incontinence in women who are also having vaginal prolapse repair. About 476 participants will be randomly assigned to one of the two treatments and followed for 24 months. The goal is to …

This study compares a mobile app-guided pelvic floor exercise program to standard in-person rehabilitation for women with stress or mixed urinary incontinence. Thirty-two adult women will follow either the app or in-person sessions for 3 months. Researchers will measure changes i…

This study tests whether a small electrical device (TENS) can reduce pain for women undergoing an in-office procedure for stress urinary incontinence. About 100 women will be randomly assigned to receive either real TENS or a placebo device during the procedure. The goal is to se…

This study tests a 12-week pelvic floor exercise program for women aged 65 and older living in nursing homes who have stress urinary incontinence (leakage with coughing, sneezing, or movement). One group will do standard exercises while watching and imagining themed videos to imp…

This study looks at whether combining Paula exercises (a type of pelvic floor training) with tibial nerve stimulation (a non-invasive nerve treatment) can help women with stress urinary incontinence. The goal is to reduce leakage, strengthen pelvic muscles, improve sexual functio…

This study tests a device that sends mild electrical pulses to the pelvic floor muscles to help men who have bladder leakage after prostate cancer treatment. About 41 men with moderate leakage for at least 6 months will use the device at home for 20 minutes a day, 5 days a week, …

This study tests whether combining Swiss ball exercises with diaphragmatic breathing can reduce stress urinary incontinence (leaking urine when coughing, sneezing, or exercising) in pregnant women. Forty-two pregnant women with mild to moderate incontinence will be split into two…

This study tests whether adding breathing training to standard pelvic floor therapy helps new moms with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). About 58 women who are 6 weeks to 6 months postpartum will either get standard care or stand…

This study compares two home exercise programs for women with stress urinary incontinence (leakage during coughing, sneezing, or exercise). One program focuses on pelvic floor muscles, the other on core stabilization. Fifty-one women will participate in a 12-week program, and res…

This study tests whether letting a bladder catheter fall out on its own (passive removal) is better than having a nurse pull it out (active removal) after urological surgery. 160 men will be randomly assigned to one method. Researchers will measure satisfaction, pain, and anxiety…

This study tests a new device designed to help women with stress urinary incontinence—leaking urine when coughing, sneezing, or exercising. The trial will compare the real device to a sham (fake) device in 96 women over 12 weeks. The main goal is to see if the device reduces urin…

This study compares two ways of doing a common surgery for pelvic organ prolapse and stress incontinence. Doctors want to know if placing a small mesh sling before or after lifting the vagina leads to better bladder control and happier patients. About 110 women having robotic sur…

This study compares a newer exercise method called Dynamic Neuromuscular Stabilization (DNS) to standard pelvic floor muscle training for women with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). About 62 women will be randomly assigned to one…

This study compares two surgeries for stress urinary incontinence (leaking urine when coughing or sneezing) in women. One method uses a synthetic mesh sling, while the other repairs natural tissues without mesh. Researchers will track symptom improvement, recovery time, pain, and…

This study tests a chair called Emsella that uses electromagnetic energy to treat stress urinary incontinence—leaking urine when coughing, sneezing, or exercising. About 110 adults aged 18 to 80 will sit in either the real chair or a fake (sham) chair to see if it reduces leaks b…

This study tests whether a Chinese herbal medicine formula called S-2196 can safely reduce urine leakage in women aged 55 and older with stress urinary incontinence. Fifteen participants will take the herbal formula for 2 weeks, and researchers will measure changes in leakage amo…

This study looks at whether daily text message reminders to do pelvic floor exercises can help men recover bladder control faster after prostate surgery. About 132 men who are planning to have prostate surgery will be split into two groups: one gets the text reminders, the other …

This study looks at whether taking antibiotics before a procedure to treat stress urinary incontinence (leaking urine with cough or sneeze) can lower the chance of getting a urinary tract infection (UTI) afterward. About 138 women will receive either antibiotics or a placebo befo…

This study compares two exercise approaches—pelvic floor muscle training and Pilates—to see which better reduces urinary incontinence in postmenopausal women. Twenty-four women with stress incontinence will be randomly assigned to one of the two groups for three months. Researche…

This study tests whether injecting sterile saline into the space behind the pubic bone before placing a sling for stress incontinence can reduce the risk of accidentally poking the bladder. About 300 women scheduled for this surgery will be randomly assigned to receive the inject…

This study is a long-term registry that will follow 1,000 women who receive pelvic mesh products for stress urinary incontinence or pelvic organ prolapse. Researchers will track how well the mesh works and any complications over 5 to 10 years. The goal is to gather real-world dat…

This study looks at why some women develop stress urinary incontinence (leaking urine when coughing or sneezing) after surgery for pelvic organ prolapse. Researchers will follow 382 women who have no incontinence before surgery, using phone calls and questionnaires at 3, 6, and 1…

This study looks at 30 women who have had surgery for stress urinary incontinence before but still have symptoms. Researchers want to see if using a special test (urodynamics or video-urodynamics) before another surgery helps improve results. The goal is to find out which test is…

This study tests a new method to help patients understand complex spine or prostate surgeries before they agree to them. Instead of just reading a form, patients watch multimedia content and answer questions to check their understanding. The goal is to see if this approach makes …

This study looks at how well three AI models—ChatGPT, Gemini, and Deepseek—can diagnose and suggest treatments for urology diseases. Researchers will use 800 past patient records from four hospitals to check the AI's accuracy and usefulness. The goal is to understand if AI can he…

This early study tests a new approach for stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). Researchers will stimulate nerves near the urethra in 20 women to see if it increases urethral pressure, which could help prevent leaks. The goal is to un…

This study looks at whether using ultrasound imaging and muscle activity sensors together can help women with weak pelvic floor muscles stick with their exercises and get better results. About 70 women will try different feedback methods during training. The goal is to find the b…

This study looks at whether a short, intense trampoline workout can cause urine leakage or changes in pelvic floor structure in active women aged 18-40 who say they don't have incontinence. Thirty participants will jump for 10 minutes while researchers use ultrasound to measure p…