Personalized nerve implant aims to stop bladder leaks

NCT ID NCT06885931

Recruiting now Disease control Sponsor: Amber Therapeutics Ltd Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a small, implanted device that stimulates the pudendal nerve to help control bladder function in women with mixed urinary incontinence (both stress and urge leaks). The device is personalized and adapts to each person's needs. Researchers will check if the procedure is safe and if it improves symptoms like leakage and urgency.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: implanted pudendal neuromodulation device (Picostim II system)
What this could lead to: If successful, this could offer a new, personalized treatment option for people with mixed urinary incontinence who haven't been helped by other therapies.
What could go wrong: This is an early feasibility study with only 86 participants, so results may not apply to everyone. The device requires surgery and carries risks like infection or device-related problems.

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Conditions

The condition(s) this trial relates to.

female stress incontinence overactive bladder Urinary Incontinence, Stress Urinary Incontinence, Urge

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC PELVIC PAIN MIXED URINARY INCONTINENCE STRESS URINARY INCONTINENCE (SUI) URGE URINARY INCONTINENCE

Contacts and locations

Locations

Ghent University Hospital
RECRUITING

Ghent, 9000, Belgium
Guy's Hospital
NOT_YET_RECRUITING

London, United Kingdom
Maastricht UMC
RECRUITING

Maastricht, 6229 HX, Netherlands
Southmead Hospital
RECRUITING

Bristol, United Kingdom
UZ Leuven
RECRUITING

Leuven, Herestraat 49, 3000, Belgium
Universitair Ziekenhuis Antwerpen
RECRUITING

Edegem, 655, 2650, Belgium
University College London Hospital
RECRUITING

London, NW1 2BU, United Kingdom

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