Overactive bladder

This study is checking how well the Altaviva™ device works over five years for people with sudden, strong urges to urinate (urge incontinence). The device sends mild electrical pulses to a nerve in the ankle to calm bladder signals. Researchers will track 256 adults to see if at …

This study tests a daily pill called vibegron to see if it safely improves bladder control in children aged 2 to 18 with neurogenic detrusor overactivity (NDO), a condition where the bladder contracts too often due to nerve damage. Participants must already use a catheter to empt…

This study is following 55 adults who have an implanted device that stimulates nerves to control overactive bladder. Researchers want to see if the device safely improves quality of life over the long term. Participants must have already tried other treatments without success.

This study tests a small, implanted device that stimulates the pudendal nerve to help control bladder function in women with mixed urinary incontinence (both stress and urge leaks). The device is personalized and adapts to each person's needs. Researchers will check if the proced…

This study tests whether adding high-dose vitamin D to standard care helps children with overactive bladder (wet) reach their goal of zero leakage. About 180 children aged 5 and older with low vitamin D levels will receive either standard treatment alone or standard treatment plu…

This study tests whether low-intensity shockwave therapy can improve overactive bladder symptoms in women as well as or better than the standard drug solifenacin. Seventy women will be randomly assigned to receive either weekly shockwave sessions for 8 weeks or a daily pill for 1…

This study looks at how two different types of bladder medication affect thinking skills in women aged 60 and older who have sudden, strong urges to urinate. Participants will be randomly assigned to take one of two drugs or a placebo for 6 months. The goal is to see which option…

This early study tests a single treatment of EG110A injections into the bladder muscle for adults with spinal cord injury who still have bladder leaks despite standard care. The goal is to see if the treatment is safe and can reduce incontinence. Sixteen participants will be foll…

This study is testing a small device called eCoin that is implanted under the skin to stimulate a nerve in the leg. The goal is to reduce sudden, strong urges to urinate that lead to leaks. Researchers will track 200 adults with overactive bladder to see if the device safely cuts…

This study tests whether giving patients a special nutritional drink (immunonutrition) before bladder removal surgery can reduce complications like infections. About 232 adults having open cystectomy for various bladder conditions will be randomly assigned to receive the drink or…

This study tests whether injecting platelet-rich plasma (PRP) into the bladder wall can help people with overactive bladder that hasn't improved with standard treatments. PRP, made from a patient's own blood, is compared to Botox, a common treatment for this condition. About 48 a…

This study tests whether taking the antibiotic ciprofloxacin for three days after bladder Botox injections reduces the risk of urinary tract infections in women with overactive bladder. About 202 women will be randomly assigned to receive either the antibiotic or a placebo pill. …

This study is testing the NXT Urodynamics System, a device used to measure how well the bladder stores and releases urine. Researchers want to confirm it is safe and works correctly in people with bladder problems like incontinence or overactive bladder. About 180 adults who need…

This study tests a new device called the Glean Urodynamics System, which uses sensors and an app to monitor bladder function both in the clinic and at home. It includes 101 adults with bladder issues like overactive bladder or incontinence. The goal is to see if the device is saf…

This study tests a new ultrasound method to measure bladder function without invasive procedures. Researchers at Mayo Clinic will compare the new technique to standard tests in adults with bladder issues or enlarged prostate. The goal is to see if this painless approach can accur…

This study tests an online screening tool (website or app) to help people with frequent urination get diagnosed with overactive bladder earlier. About 1,000 adults who often need to urinate more than 7 times a day will use the tool and then see a specialist to confirm the diagnos…

This study tests whether gentle electrical stimulation of nerves in the leg or lower back can prevent the bladder from becoming overactive after a spinal cord injury. Researchers will compare two types of nerve stimulation against standard care in 45 adults who had a spinal injur…

This study tests whether taking zinc supplements before a Botox injection can improve results for women with overactive bladder. 72 women will receive either zinc or a placebo pill for five days before their Botox treatment. Researchers will track how many need another injection …

This study is testing a new external device (Axonics ETS-02) to see if it is safe and works for people with overactive bladder or fecal incontinence. About 75 adults will wear the device for a short trial period. The goal is to check if the device stays attached and works properl…

This study tests a device called the Axonics SNM System, which uses mild electrical pulses to calm the nerves that control the bladder. It is for men with overactive bladder, including those with urgency incontinence or frequent urination. The trial will enroll 150 men and track …

This study looks at whether a combination of two drugs (solifenacin and mirabegron) at low doses works better than a high dose of either drug alone for children aged 5 to 14 with daytime wetting. About 236 children who did not fully respond to low-dose single drugs will be random…

This study tests whether injecting Botox into the bladder wall during a standard prostate surgery (HoLEP) can better control overactive bladder symptoms like sudden urges to urinate and leakage. About 66 men aged 18-89 with these symptoms will be randomly assigned to get Botox or…

This early study tests a new implantable device that senses bladder nerve signals and delivers stimulation to reduce sudden urges to urinate. Ten women with overactive bladder that hasn't improved with standard treatments will receive the device. The goal is to see if the device …

This study tests whether a non-invasive nerve stimulation device placed on the ankle can reduce bladder symptoms like urgency and frequent urination in people with multiple sclerosis. 72 participants will be randomly assigned to receive either real or sham stimulation over severa…

This study tests two types of gentle stimulation—magnetic or electrical—applied over the lower back to help control bladder overactivity in people with spinal cord injury. Forty adults aged 18-65 who still have bladder leaks despite medication will receive 20 sessions over four w…

This study tests a special sock called the ZIDA Control Sock that gives mild electrical pulses near the ankle to help people with overactive bladder who still have leaks despite taking medicine. About 20 adults will use the sock at home once a week for 12 weeks while staying on t…

This study tests whether low-energy shock wave therapy, a non-invasive treatment, can improve overactive bladder symptoms in women who also have metabolic syndrome. Sixty women will receive either the real therapy or a sham procedure. Researchers will track symptom changes using …

This study is testing whether taking pumpkin seed oil extract can improve bladder function in people with overactive bladder. Researchers will ask 40 participants to take the supplement for 12 weeks and track their symptoms using surveys. The goal is to see if this natural option…

This study tests a device that sends mild electrical pulses to the pelvic floor muscles to help men who have bladder leakage after prostate cancer treatment. About 41 men with moderate leakage for at least 6 months will use the device at home for 20 minutes a day, 5 days a week, …

This study tests a new hormone-free gel for women with genitourinary syndrome of menopause (GSM), which causes vaginal dryness, pain, and other symptoms. About 80 postmenopausal women will use the gel for 8 weeks. Researchers will measure changes in quality of life using a questi…

This study tests a non-invasive brain stimulation technique called rTMS to improve bladder symptoms in women with multiple sclerosis. Participants receive either real or sham treatment over 10 sessions. The goal is to see if targeting specific brain areas can reduce urinary urgen…

This study tests whether letting a bladder catheter fall out on its own (passive removal) is better than having a nurse pull it out (active removal) after urological surgery. 160 men will be randomly assigned to one method. Researchers will measure satisfaction, pain, and anxiety…

This study tests a small implanted device that stimulates a nerve in the lower back to help control sudden, urgent urination. Thirty adults who have not been helped by standard medications will use the device for 30 minutes each day. Researchers will check if it reduces leaking e…

This study compares two X-ray settings during a procedure to treat overactive bladder. The goal is to see if a new setting reduces radiation exposure while still placing the device correctly. About 44 adults with overactive bladder will take part. The results could make this comm…

This early study tests a device called UCon, which is placed on the skin to send mild electrical pulses to nerves that control the bladder and bowel. The goal is to reduce symptoms like sudden urges, leaks, and frequent bathroom trips in women with overactive bladder or bowel dys…

This study compares two medicines—tadalafil (a drug often used for erectile dysfunction) and solifenacin (a standard OAB treatment)—to see which works better for women with overactive bladder. About 480 women in Egypt will take one pill daily for 12 weeks. Researchers will track …

This study looks at whether a 3-day trial of a nerve-stimulating device for bladder control works as well as the standard 7-day trial. About 193 women with urgent or frequent urination will be randomly assigned to either a 3-day or 7-day test. The goal is to see if the shorter tr…

This study tests a non-implanted electrical stimulation device for women with overactive bladder (OAB). About 151 participants will use the device or take medication to see if the device safely reduces daily bathroom trips. The goal is to offer a non-surgical option for symptom r…

This study looks at whether yoga can improve overactive bladder symptoms in children aged 8 to 18. Participants attend a weekly yoga session for 6 weeks. Researchers will track symptom changes using questionnaires and urine tests. The goal is to find a gentle, non-drug option for…

This study tests a device that uses radiofrequency energy inside the vagina to treat overactive bladder in women. It includes 202 women aged 22 to 80 who have had symptoms for at least 6 months. Half will get the real treatment and half a sham (fake) treatment to see if the devic…

This study tests whether a skin patch that delivers oxybutynin works better than oral pills to reduce bladder pain and urgency in children after bladder surgery. About 100 children aged 4 to 8 will be enrolled. The goal is to see if the patch provides better relief and reduces th…

This study tests if electrical stimulation applied to the vaginal area or the perineum (the area between the vagina and anus) can help women with overactive bladder. 63 women will be split into three groups: one gets vaginal stimulation plus bladder training, another gets perinea…

This study looks at whether women with overactive bladder can remove a temporary nerve testing lead at home instead of coming back to the doctor's office. The lead is placed during a short procedure to see if a permanent nerve stimulator might help. Researchers want to know if wo…

This study tests whether a chair that uses electromagnetic pulses to strengthen pelvic floor muscles can help people with overactive bladder. About 166 adults who have not gotten relief from lifestyle changes or medications will sit in the chair twice a week for four weeks. Half …

This study compares two treatments for children with overactive bladder (OAB) of unknown cause: the standard medication oxybutynin and a nerve stimulation therapy (PTNS). About 124 children aged 6 to 16 will be randomly assigned to one treatment for three months. The goal is to s…

This study tests whether a prescription app called RiSolve can reduce overactive bladder symptoms in women better than standard educational handouts. About 596 women will use the app for 10 weeks or receive paper guides. Researchers will measure changes in symptom severity and qu…

This study tests whether women living in rural areas can use a simple TENS device at home to reduce overactive bladder symptoms. Thirty-eight women will apply mild electrical stimulation to a nerve in their ankle for 30 minutes, three times a week for 12 weeks. Researchers will t…

This study is testing a new device called Tensi+ that uses mild electrical pulses to help people with overactive bladder. Researchers will track 500 adults for one year to see if the device improves symptoms like sudden urges to urinate. The goal is to learn how well it works and…

This early study tests a device called UCon that sends mild electrical pulses through the skin to calm bladder nerves. Twenty men with overactive bladder will use the device at home for a few weeks. The goal is to see if it is safe and if it reduces urgency, leaks, and nighttime …

This study tests whether taking a daily lactobacillus probiotic can reduce symptoms of overactive bladder in women. One hundred women with the condition will take either the probiotic or a placebo for six months. Researchers will track symptom changes and check the bacteria in th…

This study aims to understand how sacral neuromodulation (a nerve-stimulating device) changes the autonomic nervous system in people with overactive bladder. Researchers will measure heart rate variability in 40 adults during the device implantation procedure. The goal is to find…

This study looks at brain activity in children with overactive bladder and daytime wetting compared to healthy children. Researchers use MRI scans to see if brain areas that control the bladder work differently. They also test if a gentle nerve stimulation treatment (TENS) change…

This study looks at whether the position a person is in during a urodynamic exam (a test that measures bladder function) affects the diagnosis of an overactive bladder in people with multiple sclerosis or Parkinson's disease. Researchers will compare results from tests done while…

This study looks at the bacteria found in urine, the genital area, and stool of children with overactive bladder and daytime wetting, comparing them to healthy children. Researchers want to see if these bacteria differ between the groups and if they change with treatment or as ki…

This study from the University of Zurich is looking at how tiny organisms (microbes) and the immune system interact in the bladder. Researchers will collect samples from 800 adults with various urinary conditions, including infections, bladder pain, and overactive bladder, as wel…

This study looks at how bladder sensations during filling are linked to overactive bladder severity in people with multiple sclerosis. Researchers will perform repeated cystometries, including a test with a distracting task, to assess sensation reliability. The goal is to better …

This study aims to collect electrical signals from the body in people with overactive bladder, fecal incontinence, or urinary retention who are receiving sacral neuromodulation therapy. Researchers will gather data at several time points during the evaluation period to better und…

This study tests a new method to help patients understand complex spine or prostate surgeries before they agree to them. Instead of just reading a form, patients watch multimedia content and answer questions to check their understanding. The goal is to see if this approach makes …

This study looks at how well three AI models—ChatGPT, Gemini, and Deepseek—can diagnose and suggest treatments for urology diseases. Researchers will use 800 past patient records from four hospitals to check the AI's accuracy and usefulness. The goal is to understand if AI can he…

This study aims to understand how electrical stimulation of the sacral nerve helps people with overactive bladder. Researchers will test two different ways to set the stimulation and see which one works better. Fifteen adults who already qualify for a sacral nerve implant will pa…

This study tests a personalized mobile tool to help women with overactive bladder (OAB) start and stick with treatment. About 30 women will use the app to learn about their condition, track symptoms, and get support. The goal is to see if the tool improves bladder health knowledg…

This study aims to find out how often sexual dysfunction occurs in women with relapsing-remitting multiple sclerosis and how it connects to fatigue, depression, anxiety, overactive bladder, and thinking problems. Researchers will use questionnaires and tests to measure these fact…

This study looks at how Botox injections for overactive bladder affect the community of bacteria in the urinary tract of postmenopausal women. Researchers will collect urine samples before and after treatment to see if changes in the microbiome relate to treatment success or side…