Daily pill aims to improve bladder function in children with spinal conditions
NCT ID NCT05491525
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a daily pill called vibegron to see if it safely improves bladder control in children aged 2 to 18 with neurogenic detrusor overactivity (NDO), a condition where the bladder contracts too often due to nerve damage. Participants must already use a catheter to empty their bladder. The trial measures changes in bladder capacity and pressure during filling, aiming to reduce leakage and improve quality of life.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
vibegron
What this could lead to
If successful, vibegron could offer a new oral treatment option to help children with neurogenic bladder hold more urine and reduce involuntary bladder contractions.
What could go wrong
This is an early-to-mid-stage trial with no placebo group, so results may be less definitive. Side effects or lack of efficacy could limit its use.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Aarhus University Hospital - Department of Paediatrics and Adolescent Medicine
RECRUITINGAarhus, 8200, Denmark
Contact
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Albany Medical College
RECRUITINGAlbany, New York, 12208, United States
Contact
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Alberta Children's Hospital
RECRUITINGCalgary, Alberta, T3B 6A8, Canada
Contact
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Ankara University Faculty of Medicine Ibni Sina Hospital
RECRUITINGAnkara, Altindag, 6230, Turkey (Türkiye)
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Arkansas Childrens Hospital
RECRUITINGLittle Rock, Arkansas, 72202, United States
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Children and Youth Health Care Institute of Vojvodina
RECRUITINGNovi Sad, 21000, Serbia
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Children's Hospital Colorado
RECRUITINGAurora, Colorado, 800045, United States
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Children's Hospital of Orange County
TERMINATEDOrange, California, 92868-4568, United States
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Childrens Clinical University Hospital
WITHDRAWNRiga, LV-1004, Latvia
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Childrens Hospital New Orleans
WITHDRAWNNew Orleans, Louisiana, 70118, United States
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Detská fakultná nemocnica s poliklinikou/Národný ústav detských chorôb (NÚDCH)
RECRUITINGBratislava, 83301, Slovakia
Contact
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Duke University Medical Center
TERMINATEDDurham, North Carolina, 27710, United States
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Hospital Umum Sarawak
RECRUITINGKuching, Sarawak, 93586, Malaysia
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Hospital of Lithuanian University of Health Sciences Kauno klinikos
RECRUITINGKaunas, LT-50161, Lithuania
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Institutul Clinic Fundeni
RECRUITINGBucharest, Bucharest, 22328, Romania
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Instytut Pomnik - Centrum Zdrowia Dziecka
RECRUITINGWarsaw, 04-736, Poland
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Irbid Specialty Hospital
RECRUITINGIrbid, 21110, Jordan
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Istiklal Hospital
RECRUITINGAmman, 11821, Jordan
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JSC Evex Hospital M. lashvili Childrens Central Hospital
RECRUITINGTbilisi, 0159, Georgia
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Jordan University Hospital
RECRUITINGAmman, 11942, Jordan
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Kuala Lumpur Hospital
RECRUITINGKuala Lumpur, Kuala Lumpur, 50586, Malaysia
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Maria Sklodowska Curie Childrens Clinical Emergency Hospital
RECRUITINGBucharest, Bucharest, 41451, Romania
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Mersin University, Dept. of Urology
RECRUITINGYenişehir, 33343, Turkey (Türkiye)
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National Children's Hospital
RECRUITINGQuezon City, National Capital Region, 1102, Philippines
Contact
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Nemours Childrens Health, Jacksonville
RECRUITINGJacksonville, Florida, 32207, United States
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Oregon Health & Science University
WITHDRAWNPortland, Oregon, 97239, United States
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SUNY Upstate Medical University
RECRUITINGSyracuse, New York, 13210, United States
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The Hospital for Sick Children
RECRUITINGToronto, Ontario, M5G 1E8, Canada
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UZ Gent
RECRUITINGGhent, East Flanders, 9000, Belgium
Contact
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Universitair Ziekenhuis Antwerpen
WITHDRAWNEdegem, Antwerpen, 2650, Belgium
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University Children's Hospital Tirsova
RECRUITINGBelgrade, 11000, Serbia
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University Hospital Split - KBC Split
RECRUITINGSplit, 21000, Croatia
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University of Oklahoma
RECRUITINGOklahoma City, Oklahoma, 73104, United States
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Uniwersytecki Dzieciecy Szpital Kliniczny im. L. Zamenhofa
RECRUITINGBialystok, 15-274, Poland
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Uniwersyteckie Centrum Kliniczne
RECRUITINGGdansk, 80-952, Poland
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Urologická ambulancia J. BREZA MEDICAL s.r.o.
RECRUITINGBratislava, 85101, Slovakia
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Vilnius University Hospital Santaros Klinikos
RECRUITINGVilnius, LT-08406, Lithuania
Contact
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Wichita Urology Group
RECRUITINGWichita, Kansas, 67226, United States
Contact